Helminthic Therapy wiki - Recent changes [en]

Helminthic therapy and COVID-19

John — Fri, 13 Nov 2026 17:23:28 GMT

Helminthic therapy and neuropsychiatric disorders

Cloize — Fri, 13 Nov 2026 10:51:03 GMT

Temporarily increased depression

Helminthic therapy and aging

Jlm — Fri, 13 Nov 2026 07:48:21 GMT

The scientific evidence

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	* 2018 Dec [https://pubmed.ncbi.nlm.nih.gov/30366039/ Early life infection and host senescence]		* 2018 Dec [https://pubmed.ncbi.nlm.nih.gov/30366039/ Early life infection and host senescence]
	* 2015 Apr [https://pubmed.ncbi.nlm.nih.gov/25545318/ Impairment of host resistance to helminthes with age in murine small intestine]		* 2015 Apr [https://pubmed.ncbi.nlm.nih.gov/25545318/ Impairment of host resistance to helminthes with age in murine small intestine]
			* 2005 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/15615726/ Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus]

	See also		See also
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	* 2020 Aug [https://pubmed.ncbi.nlm.nih.gov/32718231/ Eosinophils and White Fat: Protection from Worms and Inflammaging]		* 2020 Aug [https://pubmed.ncbi.nlm.nih.gov/32718231/ Eosinophils and White Fat: Protection from Worms and Inflammaging]
	* 2018 Feb 28 [https://pubmed.ncbi.nlm.nih.gov/29491449/ Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection]		* 2018 Feb 28 [https://pubmed.ncbi.nlm.nih.gov/29491449/ Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection]
	* 2005 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/15615726/ Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus]

	'''Lipopolysaccharide (LPS)'''		'''Lipopolysaccharide (LPS)'''

Helminthic therapy research

Jlm — Fri, 13 Nov 2026 07:47:40 GMT

2005

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	* 2005 Mar 21 [https://www.jacionline.org/article/S0091-6749(04)04088-6/fulltext Infection with Litosomoides sigmodontis suppresses allergen-induced sensitization and pulmonary inflammation in a murine asthma model] (Conference)		* 2005 Mar 21 [https://www.jacionline.org/article/S0091-6749(04)04088-6/fulltext Infection with Litosomoides sigmodontis suppresses allergen-induced sensitization and pulmonary inflammation in a murine asthma model] (Conference)
	* 2005 Mar 20 [https://www.jacionline.org/article/S0091-6749(04)03733-9/fulltext Immune response in asthma: Down modulation by Schistosoma mansoni infection] (Conference)		* 2005 Mar 20 [https://www.jacionline.org/article/S0091-6749(04)03733-9/fulltext Immune response in asthma: Down modulation by Schistosoma mansoni infection] (Conference)
			* 2005 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/15615726/ Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus]
	* 2005 Mar [https://pubmed.ncbi.nlm.nih.gov/15730384 Low dose chronic Schistosoma mansoni infection increases susceptibility to Mycobacterium bovis BCG infection in mice] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809318/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809318/pdf/cei0139-0398.pdf PDF]		* 2005 Mar [https://pubmed.ncbi.nlm.nih.gov/15730384 Low dose chronic Schistosoma mansoni infection increases susceptibility to Mycobacterium bovis BCG infection in mice] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809318/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809318/pdf/cei0139-0398.pdf PDF]
	* 2005 Mar [https://pubmed.ncbi.nlm.nih.gov/15784107/ Wheeze, allergic sensitization and geohelminth infection in Butajira, Ethiopia]		* 2005 Mar [https://pubmed.ncbi.nlm.nih.gov/15784107/ Wheeze, allergic sensitization and geohelminth infection in Butajira, Ethiopia]

Helminthic therapy and aging

Jlm — Fri, 13 Nov 2026 07:47:20 GMT

The scientific evidence

← Older revision		Revision as of 07:47, 13 November 2026
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	* 2020 Aug [https://pubmed.ncbi.nlm.nih.gov/32718231/ Eosinophils and White Fat: Protection from Worms and Inflammaging]		* 2020 Aug [https://pubmed.ncbi.nlm.nih.gov/32718231/ Eosinophils and White Fat: Protection from Worms and Inflammaging]
	* 2018 Feb 28 [https://pubmed.ncbi.nlm.nih.gov/29491449/ Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection]		* 2018 Feb 28 [https://pubmed.ncbi.nlm.nih.gov/29491449/ Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection]
			* 2005 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/15615726/ Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus]

	'''Lipopolysaccharide (LPS)'''		'''Lipopolysaccharide (LPS)'''

Mechanisms underlying helminth colonization

Jlm — Fri, 13 Nov 2026 07:46:59 GMT

Brain and neuronal impact

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	* 2011 Jul [https://pubmed.ncbi.nlm.nih.gov/20723599/ IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection]		* 2011 Jul [https://pubmed.ncbi.nlm.nih.gov/20723599/ IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection]
	* 2009 Sep [https://pubmed.ncbi.nlm.nih.gov/19575707/ Interleukin-10 provides direct trophic support to neurons]		* 2009 Sep [https://pubmed.ncbi.nlm.nih.gov/19575707/ Interleukin-10 provides direct trophic support to neurons]
			* 2005 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/15615726/ Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus]
	* 2005 Feb [https://pubmed.ncbi.nlm.nih.gov/15611352/ APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil]		* 2005 Feb [https://pubmed.ncbi.nlm.nih.gov/15611352/ APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil]
	* 1999 Aug [https://pubmed.ncbi.nlm.nih.gov/10415151/ Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats]		* 1999 Aug [https://pubmed.ncbi.nlm.nih.gov/10415151/ Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats]
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	* 2006 [https://open.uct.ac.za/items/57b0aba9-7748-4e3a-a884-c61474847f89 The role of IL-4Ra during acute schistosomiasis] (Thesis, Cape Town)		* 2006 [https://open.uct.ac.za/items/57b0aba9-7748-4e3a-a884-c61474847f89 The role of IL-4Ra during acute schistosomiasis] (Thesis, Cape Town)
	* 2005 Apr 8 [https://ediss.sub.uni-hamburg.de/handle/ediss/998 Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus] (Thesis, Hamburg)		* 2005 Apr 8 [https://ediss.sub.uni-hamburg.de/handle/ediss/998 Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus] (Thesis, Hamburg)
			* 2005 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/15615726/ Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus]
	* 2004 Mar [https://pubmed.ncbi.nlm.nih.gov/15030771/ Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production]		* 2004 Mar [https://pubmed.ncbi.nlm.nih.gov/15030771/ Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production]
	* 2003 Jul 15 [https://pubmed.ncbi.nlm.nih.gov/12847266/ Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves]		* 2003 Jul 15 [https://pubmed.ncbi.nlm.nih.gov/12847266/ Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves]

The hookworm inoculation rash

John — Fri, 13 Nov 2026 03:53:09 GMT

Helminth therapy studies in murine models

Jlm — Thu, 12 Nov 2026 08:39:50 GMT

Methodology

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	== Methodology ==		== Methodology ==

			* 2026 Nov 2 [https://pubmed.ncbi.nlm.nih.gov/42831859/ Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic]

	* 2026 Apr 14 [https://pubmed.ncbi.nlm.nih.gov/41980702/ The Trouble with "Clean" Mice: How Infection History Alters Host Immune Responses]		* 2026 Apr 14 [https://pubmed.ncbi.nlm.nih.gov/41980702/ The Trouble with "Clean" Mice: How Infection History Alters Host Immune Responses]

Mechanisms underlying helminth colonization

Jlm — Thu, 12 Nov 2026 06:58:47 GMT

Lipopolysaccharide (LPS)

Helminthic therapy and graft-versus-host disease (GVHD)

Jlm — Wed, 11 Nov 2026 21:54:00 GMT

The scientific evidence

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	* 2019 Mar [https://www.astctjournal.org/article/S1083-8791(18)31492-7/fulltext Intestinal Immune Conditioning with Helminths Employs Host T Helper 2 (Th2) Pathway to Induce Mixed Chimerism and Regulate Graft-Versus-Host Disease] -- [https://www.astctjournal.org/article/S1083-8791(18)31492-7/pdf PDF]		* 2019 Mar [https://www.astctjournal.org/article/S1083-8791(18)31492-7/fulltext Intestinal Immune Conditioning with Helminths Employs Host T Helper 2 (Th2) Pathway to Induce Mixed Chimerism and Regulate Graft-Versus-Host Disease] -- [https://www.astctjournal.org/article/S1083-8791(18)31492-7/pdf PDF]

	* 2018 Oct 5 [https://~~www~~.ncbi.nlm.nih.gov/~~pubmed~~/~~30291167~~ Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6219912/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC6219912/pdf/nihms-1506720.pdf PDF]		* 2018 Oct 5 [https://pubmed.ncbi.nlm.nih.gov/30291167/ Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6219912/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC6219912/pdf/nihms-1506720.pdf PDF]

	* 2015 Feb 1 [~~http~~://~~www~~.ncbi.nlm.nih.gov/~~pubmed~~/~~25527786~~ Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versustumor effect in mice] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4297687/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4297687/pdf/nihms644178.pdf PDF] (Helminths improve the outcome of bone marrow transplantation in mice)		* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25527786/ Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versustumor effect in mice] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4297687/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4297687/pdf/nihms644178.pdf PDF] (Helminths improve the outcome of bone marrow transplantation in mice)

	* 2010 May [https://www.gastrojournal.org/article/S0016-5085(10)60071-6/fulltext Helminths Regulate Acute Graft Versus Host Disease and Colitis in a TGFβ Dependent Manner in Mice]		* 2010 May [https://www.gastrojournal.org/article/S0016-5085(10)60071-6/fulltext Helminths Regulate Acute Graft Versus Host Disease and Colitis in a TGFβ Dependent Manner in Mice]

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 21:52:12 GMT

Mast cells

Helminthic therapy and infectious diseases

Jlm — Wed, 11 Nov 2026 21:19:21 GMT

Helminthic therapy and Epstein–Barr virus (EBV)

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	* 2026 May 13 [https://www.biorxiv.org/content/10.64898/2026.05.11.723779v1.abstract Helminth coinfection facilitates gammaherpesvirus infection in the wood mouse Apodemus sylvaticus] (Preprint)		* 2026 May 13 [https://www.biorxiv.org/content/10.64898/2026.05.11.723779v1.abstract Helminth coinfection facilitates gammaherpesvirus infection in the wood mouse Apodemus sylvaticus] (Preprint)
	* 2025 Nov [https://academic.oup.com/jimmunol/article/214/Supplement_1/vkaf283.108/8329497 Metabolic state of tissue resident macrophages is altered by preexisting helminth infection]		* 2025 Nov [https://academic.oup.com/jimmunol/article/214/Supplement_1/vkaf283.108/8329497 Metabolic state of tissue resident macrophages is altered by preexisting helminth infection]
	* 2023 Oct 17 [https://pubmed.ncbi.nlm.nih.gov/37847677/ Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages] -- [https://~~pmc~~.~~ncbi~~.~~nlm.nih.gov~~/~~articles~~/~~PMC10581490~~/ ~~Full text] \| [https:~~//~~pmc.ncbi~~.~~nlm.nih.gov~~/~~articles/PMC10581490/pdf/ppat.1011691.pdf PDF~~]		* 2023 Oct 17 [https://pubmed.ncbi.nlm.nih.gov/37847677/ Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages]
			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/72.36/7946182 IL-4 receptor signaling regulates lung macrophages during helminth coinfection resulting in enhanced gammaherpesvirus permissiveness] (Conference, Immunology2023, Washington)
	* 2021 Mar 25 [https://pubmed.ncbi.nlm.nih.gov/33536178/ Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8103696/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8103696/pdf/JVI.01946-20.pdf PDF]		* 2021 Mar 25 [https://pubmed.ncbi.nlm.nih.gov/33536178/ Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8103696/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8103696/pdf/JVI.01946-20.pdf PDF]
	* 2020 Aug 28 [https://pubmed.ncbi.nlm.nih.gov/32872342/ An Absence of Epstein-Barr Virus Reactivation and Associations with Disease Activity in People with Multiple Sclerosis Undergoing Therapeutic Hookworm Vaccination]		* 2020 Aug 28 [https://pubmed.ncbi.nlm.nih.gov/32872342/ An Absence of Epstein-Barr Virus Reactivation and Associations with Disease Activity in People with Multiple Sclerosis Undergoing Therapeutic Hookworm Vaccination]

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 21:18:55 GMT

Haematopoiesis, Monocytes and macrophages

Helminthic therapy and sepsis

Jlm — Wed, 11 Nov 2026 21:11:21 GMT

The scientific evidence

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	* 2023 Oct 10 [https://pubmed.ncbi.nlm.nih.gov/37926467/ Protective effect of recombinant Schistosoma japonicum cystatin against acute kidney injury associated with acute liver failure in mice] (Chinese)		* 2023 Oct 10 [https://pubmed.ncbi.nlm.nih.gov/37926467/ Protective effect of recombinant Schistosoma japonicum cystatin against acute kidney injury associated with acute liver failure in mice] (Chinese)
	* 2022 Dec 15 [https://pubmed.ncbi.nlm.nih.gov/36558882/ rCsHscB Derived from Clonorchis sinensis: A Carcinogenic Liver Fluke Ameliorates LPS-Induced Acute Hepatic Injury by Repression of Inflammation]		* 2022 Dec 15 [https://pubmed.ncbi.nlm.nih.gov/36558882/ rCsHscB Derived from Clonorchis sinensis: A Carcinogenic Liver Fluke Ameliorates LPS-Induced Acute Hepatic Injury by Repression of Inflammation]
	* 2022 Sep 27 [https://pubmed.ncbi.nlm.nih.gov/36238295/ Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC9551057/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC9551057/pdf/fimmu-13-1013159.pdf PDF~~]		* 2022 Sep 27 [https://pubmed.ncbi.nlm.nih.gov/36238295/ Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus]
	* 2022 Aug [https://pubmed.ncbi.nlm.nih.gov/35691271/ Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages] -- [https://www.sciencedirect.com/science/article/pii/S1567576922003915?via%3Dihub Full text]		* 2022 Aug [https://pubmed.ncbi.nlm.nih.gov/35691271/ Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages] -- [https://www.sciencedirect.com/science/article/pii/S1567576922003915?via%3Dihub Full text]
	* 2022 Jun 20 [https://pubmed.ncbi.nlm.nih.gov/35790432/ Protective effect of excretory-secretory proteins from Trichinella spiralis muscle larvae against myocardial injury in septic mice] (Chinese)		* 2022 Jun 20 [https://pubmed.ncbi.nlm.nih.gov/35790432/ Protective effect of excretory-secretory proteins from Trichinella spiralis muscle larvae against myocardial injury in septic mice] (Chinese)
	* 2022 May [https://pubmed.ncbi.nlm.nih.gov/35320838/ Crude protein fraction with high thioredoxin reductase (TrxR) enzyme activity from filarial parasite Setaria cervi counters lipopolysaccharide (LPS)-induced inflammation in macrophages]		* 2022 May [https://pubmed.ncbi.nlm.nih.gov/35320838/ Crude protein fraction with high thioredoxin reductase (TrxR) enzyme activity from filarial parasite Setaria cervi counters lipopolysaccharide (LPS)-induced inflammation in macrophages]
			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.02/7946922 Fasciola hepatica Fh15 promote survival in a mouse septic shock model and downregulates inflammatory cytokines] (Conference, Immunology2023, Washington)
	* 2021 Dec 22 [https://pubmed.ncbi.nlm.nih.gov/34937173/ Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model]		* 2021 Dec 22 [https://pubmed.ncbi.nlm.nih.gov/34937173/ Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model]
	* 2021 Oct 26 [https://pubmed.ncbi.nlm.nih.gov/34868595/ Helminth infection is associated with dampened cytokine responses to viral and bacterial stimulations in Tsimane forager-horticulturalists] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634526/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634526/pdf/eoab035.pdf PDF]		* 2021 Oct 26 [https://pubmed.ncbi.nlm.nih.gov/34868595/ Helminth infection is associated with dampened cytokine responses to viral and bacterial stimulations in Tsimane forager-horticulturalists] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634526/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634526/pdf/eoab035.pdf PDF]

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 21:10:37 GMT

Fatty acid- and retinol-binding proteins (FARs) and Fatty acid binding proteins (FABPs)

Helminthic therapy and autoimmune diseases

Jlm — Wed, 11 Nov 2026 21:06:55 GMT

General reviews

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	* 2015 Oct 1 [https://pubmed.ncbi.nlm.nih.gov/26324775/ Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4651003/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4651003/pdf/nihms-712898.pdf PDF]		* 2015 Oct 1 [https://pubmed.ncbi.nlm.nih.gov/26324775/ Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4651003/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4651003/pdf/nihms-712898.pdf PDF]
	* 2014 [https://apps.dtic.mil/sti/html/tr/AD1012825/ The Use of Filariae as a Therapeutic Agent for Hypersensitivity Diseases] (Thesis, USU Bethesda)		* 2014 [https://apps.dtic.mil/sti/html/tr/AD1012825/ The Use of Filariae as a Therapeutic Agent for Hypersensitivity Diseases] (Thesis, USU Bethesda)

			See also

			* 2012 Jun 8 [https://pubmed.ncbi.nlm.nih.gov/22608500/ Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection ] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3370267/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3370267/pdf/main.pdf PDF]

	See also (not directly related) :		See also (not directly related) :

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 21:05:40 GMT

Fc receptor

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	* 2016 Apr 21 [https://pubmed.ncbi.nlm.nih.gov/27398064/ Third-stage Gnathostoma spinigerum larva excretory secretory antigens modulate function of Fc gamma receptor I-mediated monocytes in peripheral blood mononuclear cell culture]		* 2016 Apr 21 [https://pubmed.ncbi.nlm.nih.gov/27398064/ Third-stage Gnathostoma spinigerum larva excretory secretory antigens modulate function of Fc gamma receptor I-mediated monocytes in peripheral blood mononuclear cell culture]
	* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25548226/ Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I]		* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25548226/ Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I]
			* 2012 Jun 8 [https://pubmed.ncbi.nlm.nih.gov/22608500/ Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection]

	=== tryptophan metabolism ===		=== tryptophan metabolism ===

Helminthic therapy research

Jlm — Wed, 11 Nov 2026 21:05:30 GMT

2023

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	* 2023 May [https://pubmed.ncbi.nlm.nih.gov/37038955/ Immunological interactions in helminths-SARS CoV-2 coinfection: Could old enemy be a friend today?]		* 2023 May [https://pubmed.ncbi.nlm.nih.gov/37038955/ Immunological interactions in helminths-SARS CoV-2 coinfection: Could old enemy be a friend today?]

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.04/7947198 Neonatal helminth infection and chronic type 2 inflammation promotes immune suppression through FcγRIIb] (Conference, Immunology, Washington)

	* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)		* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 21:03:45 GMT

Ancylostoma secreted protein (ASP)

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	* 2015 [https://researchonline.jcu.edu.au/41286/ Hookworm Na-ASP-2 - putative functions, allergenicity and implications for vaccine development] (Thesis, James Cook)		* 2015 [https://researchonline.jcu.edu.au/41286/ Hookworm Na-ASP-2 - putative functions, allergenicity and implications for vaccine development] (Thesis, James Cook)

			* 2012 Aug-Sep [https://pubmed.ncbi.nlm.nih.gov/22651670/ Fusion of Na-ASP-2 with human immunoglobulin Fcγ abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE]

	* 2012 Jul [https://pubmed.ncbi.nlm.nih.gov/22633322/ Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths]		* 2012 Jul [https://pubmed.ncbi.nlm.nih.gov/22633322/ Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths]

Helminthic therapy and asthma

Jlm — Wed, 11 Nov 2026 21:00:43 GMT

The scientific evidence

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	* 2023 Jun [https://pubmed.ncbi.nlm.nih.gov/37058749/ Intervention effects of Trichinella spiralis excretory-secretory antigens on allergic asthma in mice]		* 2023 Jun [https://pubmed.ncbi.nlm.nih.gov/37058749/ Intervention effects of Trichinella spiralis excretory-secretory antigens on allergic asthma in mice]

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.04/7947198 Neonatal helminth infection and chronic type 2 inflammation promotes immune suppression through FcγRIIb] (Conference, Immunology, Washington)

	* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)		* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 21:00:34 GMT

IL-4

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	* 2024 Apr 24 [https://pubmed.ncbi.nlm.nih.gov/38727273/ Differentiation and Regulation of Bovine Th2 Cells In Vitro]		* 2024 Apr 24 [https://pubmed.ncbi.nlm.nih.gov/38727273/ Differentiation and Regulation of Bovine Th2 Cells In Vitro]
	* 2024 Feb 26 [https://pubmed.ncbi.nlm.nih.gov/38354709/ Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response]		* 2024 Feb 26 [https://pubmed.ncbi.nlm.nih.gov/38354709/ Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response]
			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.04/7947198 Neonatal helminth infection and chronic type 2 inflammation promotes immune suppression through FcγRIIb] (Conference, Immunology, Washington)
	* 2023 Feb 8 [https://pubmed.ncbi.nlm.nih.gov/36753434/ IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity]		* 2023 Feb 8 [https://pubmed.ncbi.nlm.nih.gov/36753434/ IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity]
	* 2023 [https://orbi.uliege.be/handle/2268/308755 Investigation of the regulation of virtual memory T cells in response to interleukin 4 during helminth infection] (Thesis, Liègue)		* 2023 [https://orbi.uliege.be/handle/2268/308755 Investigation of the regulation of virtual memory T cells in response to interleukin 4 during helminth infection] (Thesis, Liègue)
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	* 2026 Oct 15 [https://pubmed.ncbi.nlm.nih.gov/42880679/ Type III Interferons (lambda) in Parasitic Infections: Balancing Mucosal Defense and Immune Modulation]		* 2026 Oct 15 [https://pubmed.ncbi.nlm.nih.gov/42880679/ Type III Interferons (lambda) in Parasitic Infections: Balancing Mucosal Defense and Immune Modulation]

			=== Fc receptor ===

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.04/7947198 Neonatal helminth infection and chronic type 2 inflammation promotes immune suppression through FcγRIIb] (Conference, Immunology, Washington)
			* 2016 Apr 21 [https://pubmed.ncbi.nlm.nih.gov/27398064/ Third-stage Gnathostoma spinigerum larva excretory secretory antigens modulate function of Fc gamma receptor I-mediated monocytes in peripheral blood mononuclear cell culture]
			* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25548226/ Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I]

	=== tryptophan metabolism ===		=== tryptophan metabolism ===
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	* 2016 Jul 25 [https://pubmed.ncbi.nlm.nih.gov/27454771/ Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation]		* 2016 Jul 25 [https://pubmed.ncbi.nlm.nih.gov/27454771/ Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation]
	* 2016 Jul [https://pubmed.ncbi.nlm.nih.gov/27120498/ Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune evasion strategy?]		* 2016 Jul [https://pubmed.ncbi.nlm.nih.gov/27120498/ Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune evasion strategy?]
	* 2016 Apr 21 [https://pubmed.ncbi.nlm.nih.gov/27398064/ Third-stage Gnathostoma spinigerum larva excretory secretory antigens modulate function of Fc gamma receptor I-mediated monocytes in peripheral blood mononuclear cell culture]
	* 2016 Apr 8 [https://pubmed.ncbi.nlm.nih.gov/27058578/ Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections]		* 2016 Apr 8 [https://pubmed.ncbi.nlm.nih.gov/27058578/ Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections]
	* 2016 Feb [https://pubmed.ncbi.nlm.nih.gov/26627846/ Reaction norms of host immunity, host fitness and parasite performance in a mouse--intestinal nematode interaction]		* 2016 Feb [https://pubmed.ncbi.nlm.nih.gov/26627846/ Reaction norms of host immunity, host fitness and parasite performance in a mouse--intestinal nematode interaction]
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	* 2016 Feb 22 [https://pubmed.ncbi.nlm.nih.gov/26900854/ Surfactant Protein-D Is Essential for Immunity to Helminth Infection]		* 2016 Feb 22 [https://pubmed.ncbi.nlm.nih.gov/26900854/ Surfactant Protein-D Is Essential for Immunity to Helminth Infection]
	* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25139017/ Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling] (NA)		* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25139017/ Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling] (NA)
	* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25548226/ Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I]
	* 2015 Jan 8 [https://pubmed.ncbi.nlm.nih.gov/25573064/ Two potential hookworm DAF-16 target genes, SNR-3 and LPP-1: gene structure, expression profile, and implications of a cis-regulatory element in the regulation of gene expression]		* 2015 Jan 8 [https://pubmed.ncbi.nlm.nih.gov/25573064/ Two potential hookworm DAF-16 target genes, SNR-3 and LPP-1: gene structure, expression profile, and implications of a cis-regulatory element in the regulation of gene expression]
	* 2014 Dec [https://pubmed.ncbi.nlm.nih.gov/25130072/ Immune response of γδT cells in Schistosome japonicum-infected C57BL/6 mouse liver]		* 2014 Dec [https://pubmed.ncbi.nlm.nih.gov/25130072/ Immune response of γδT cells in Schistosome japonicum-infected C57BL/6 mouse liver]

Helminthic therapy research

Jlm — Wed, 11 Nov 2026 20:53:45 GMT

2023

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	* 2023 May [https://pubmed.ncbi.nlm.nih.gov/37038955/ Immunological interactions in helminths-SARS CoV-2 coinfection: Could old enemy be a friend today?]		* 2023 May [https://pubmed.ncbi.nlm.nih.gov/37038955/ Immunological interactions in helminths-SARS CoV-2 coinfection: Could old enemy be a friend today?]

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)

	* 2023 Apr 18 [https://pubmed.ncbi.nlm.nih.gov/37189818/ Helminth Lessons in Inflammatory Bowel Diseases (IBD)] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135676/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135676/pdf/biomedicines-11-01200.pdf PDF]		* 2023 Apr 18 [https://pubmed.ncbi.nlm.nih.gov/37189818/ Helminth Lessons in Inflammatory Bowel Diseases (IBD)] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135676/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135676/pdf/biomedicines-11-01200.pdf PDF]

Helminthic therapy and asthma

Jlm — Wed, 11 Nov 2026 20:53:05 GMT

The scientific evidence

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	* 2023 Jun [https://pubmed.ncbi.nlm.nih.gov/37058749/ Intervention effects of Trichinella spiralis excretory-secretory antigens on allergic asthma in mice]		* 2023 Jun [https://pubmed.ncbi.nlm.nih.gov/37058749/ Intervention effects of Trichinella spiralis excretory-secretory antigens on allergic asthma in mice]

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)

	* 2023 Mar [https://pubmed.ncbi.nlm.nih.gov/36632894/ Association of helminth infestation with childhood asthma: a nested case-control study] -- [https://www.ijidonline.com/article/S1201-9712(23)00006-1/fulltext Full text]		* 2023 Mar [https://pubmed.ncbi.nlm.nih.gov/36632894/ Association of helminth infestation with childhood asthma: a nested case-control study] -- [https://www.ijidonline.com/article/S1201-9712(23)00006-1/fulltext Full text]

Mechanisms underlying helminth colonization

Jlm — Wed, 11 Nov 2026 20:52:41 GMT

IgE

Show changes

← Older revision		Revision as of 17:23, 13 November 2026
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	== See also ==		== See also ==
			* [https://www.midwesterndoctor.com/p/the-covid-shot-was-three-vaccines The COVID Shot Was Three Vaccines, Not One & How We Can Heal From Them]
	* [[Helminthic therapy and infectious diseases \| '''Helminthic therapy and infectious diseases''']]		* [[Helminthic therapy and infectious diseases \| '''Helminthic therapy and infectious diseases''']]
	* [[Helminthic therapy and post-acute infection syndromes \| '''Helminthic therapy and post-acute infection syndromes''']]		* [[Helminthic therapy and post-acute infection syndromes \| '''Helminthic therapy and post-acute infection syndromes''']]
	* [[Helminthic therapy and sepsis \| '''Helminthic therapy and sepsis''']]		* [[Helminthic therapy and sepsis \| '''Helminthic therapy and sepsis''']]
	* [[Helminthic therapy and ME/CFS \| '''Helminthic therapy and ME/CFS''']]		* [[Helminthic therapy and ME/CFS \| '''Helminthic therapy and ME/CFS''']]

← Older revision		Revision as of 03:53, 13 November 2026
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	* [[Hookworm dosing and response \| '''Hookworm dosing and response''']]		* [[Hookworm dosing and response \| '''Hookworm dosing and response''']]
	* [[Helminth inoculation#Inoculation with NA \| '''Hookworm inoculation''']]		* [[Helminth inoculation#Inoculation with NA \| '''Hookworm inoculation''']]
			* [https://www.reddit.com/r/HelminthicTherapy/comments/1xspq6e/necator_americanus_how_to_avoid_the_inoculation/ Necator americanus: how to avoid the inoculation itch?]

← Older revision		Revision as of 10:51, 13 November 2026
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	* "Hookworms took about 24 weeks to begin to make a dent in depression - now about 2.5 years into helminths, I have some days where I'm downright optimistic. Not many, but after decades of depression it's a huge change." [https://www.facebook.com/groups/htsupport/permalink/1515697631819520/?comment_id=1515980121791271&comment_tracking=%7B%22tn%22%3A%22R1%22%7D]<!-- KR -->		* "Hookworms took about 24 weeks to begin to make a dent in depression - now about 2.5 years into helminths, I have some days where I'm downright optimistic. Not many, but after decades of depression it's a huge change." [https://www.facebook.com/groups/htsupport/permalink/1515697631819520/?comment_id=1515980121791271&comment_tracking=%7B%22tn%22%3A%22R1%22%7D]<!-- KR -->

	* ☹️ “I have anxiety and depression and have not really noticed any differences.” [https://www.facebook.com/groups/htsupport/permalink/1515697631819520/?comment_id=1516504428405507&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- SF -->		* ☹️ “I have anxiety and depression and have not really noticed any differences.” (FB, [https://www.facebook.com/groups/htsupport/permalink/1515697631819520/?comment_id=1516504428405507&comment_tracking=%7B%22tn%22%3A%22R%22%7D Dec 2017])<!-- SF -->

	* "My diagnosed anxiety/depression went down to zero. I can't get unhappy if I try. If this was the only good effect (of using HDC) it would be enough." (Link expired)		* "My diagnosed anxiety/depression went down to zero. I can't get unhappy if I try. If this was the only good effect (of using HDC) it would be enough." (Link expired)

	* “NA has definitely helped with depression, although I do not feel that my depression is severe, compared to that of others. It is definitely seasonal… After about 6 months, I began to notice improvement in mood.” [https://www.facebook.com/groups/htsupport/permalink/1803006713088609/?comment_id=1803101086412505&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- BP -->		* “NA has definitely helped with depression, although I do not feel that my depression is severe, compared to that of others. It is definitely seasonal… After about 6 months, I began to notice improvement in mood.” (FB, [https://www.facebook.com/groups/htsupport/permalink/1803006713088609/?comment_id=1803101086412505&comment_tracking=%7B%22tn%22%3A%22R%22%7D Aug 2018])<!-- BP -->

	* “As pretty much a lifelong depression sufferer (since onset of puberty anyway), I generally never liked the flat emotional effect I got from antidepressants, and always felt my depression was very much related (coincidentally at least) to my severe seasonal allergy symptoms. By the time I started hosting HW, I had given up on antidepressants for several years, and had just resigned myself to pushing through life without psych meds. About a year into hosting NA for severe allergies and asthma, I unexpectedly noticed nearly total resolution of my depressive symptoms.” [https://www.facebook.com/groups/htsupport/permalink/2190363854352891/?comment_id=2194958800560063&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- JE -->		* “As pretty much a lifelong depression sufferer (since onset of puberty anyway), I generally never liked the flat emotional effect I got from antidepressants, and always felt my depression was very much related (coincidentally at least) to my severe seasonal allergy symptoms. By the time I started hosting HW, I had given up on antidepressants for several years, and had just resigned myself to pushing through life without psych meds. About a year into hosting NA for severe allergies and asthma, I unexpectedly noticed nearly total resolution of my depressive symptoms.” (FB, [https://www.facebook.com/groups/htsupport/permalink/2190363854352891/?comment_id=2194958800560063&comment_tracking=%7B%22tn%22%3A%22R%22%7D Jun 2019])<!-- JE -->

	* “NA resolved my chronic depression - it was one of those weird, gradual, unexpected benefits.” [https://www.facebook.com/groups/htsupport/permalink/2206914002697876/?comment_id=2333833590005916&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- SA -->		* “NA resolved my chronic depression - it was one of those weird, gradual, unexpected benefits.” (FB, [https://www.facebook.com/groups/htsupport/permalink/2206914002697876/?comment_id=2333833590005916&comment_tracking=%7B%22tn%22%3A%22R%22%7D Aug 2019])<!-- SA -->

	* “HDC (I take 10 every three weeks) have a positive impact on my mood. My case may be different from others, but... PANS is what leads to my low mood. In PANS, autoantibodies attach to dopamine and glutamate receptors in the basal ganglia, which blocks their transmission in normal amounts. I think my good mood when I take HDC is likely because it helps whatever is leading to those autoantibodies being in the wrong place (my basal ganglia receptors), so more dopamine and glutamate can reach their proper destination. Not sure if these mechanics apply to many other disorders, though.” [https://www.facebook.com/groups/htsupport/permalink/2296657347056874/?comment_id=2334347929954482&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- KM -->		* “HDC (I take 10 every three weeks) have a positive impact on my mood. My case may be different from others, but... PANS is what leads to my low mood. In PANS, autoantibodies attach to dopamine and glutamate receptors in the basal ganglia, which blocks their transmission in normal amounts. I think my good mood when I take HDC is likely because it helps whatever is leading to those autoantibodies being in the wrong place (my basal ganglia receptors), so more dopamine and glutamate can reach their proper destination. Not sure if these mechanics apply to many other disorders, though.” (FB, [https://www.facebook.com/groups/htsupport/permalink/2296657347056874/?comment_id=2334347929954482&comment_tracking=%7B%22tn%22%3A%22R%22%7D Aug 2019])<!-- KM -->

	* “I thought the NA didn't do much for my mental health. But it's clear to me now that they were helping me. I got rid of my NA as part of an experiment to see if they were contributing to a sudden and consistent drop in energy I've been experiencing since May. I find that I am more depressed without them. Small problems can now push me over into the realm of crying spells and panic attacks. The HDC was helping with social anxiety and OCD, but it seems the NA was supporting a higher baseline of mental health and stability. More NA on the way to restock.” [https://www.facebook.com/groups/htsupport/permalink/1715076141881667/?comment_id=3042523755803559]<!-- KM -->		* “I thought the NA didn't do much for my mental health. But it's clear to me now that they were helping me. I got rid of my NA as part of an experiment to see if they were contributing to a sudden and consistent drop in energy I've been experiencing since May. I find that I am more depressed without them. Small problems can now push me over into the realm of crying spells and panic attacks. The HDC was helping with social anxiety and OCD, but it seems the NA was supporting a higher baseline of mental health and stability. More NA on the way to restock.” (FB, [https://www.facebook.com/groups/htsupport/permalink/1715076141881667/?comment_id=3042523755803559 Jul 2020])<!-- KM -->

	* “I’ve had so much success from the two types of friends... it’s the miracle I’ve been searching for (for 18 years) since 2001. I can’t even tell you how much happier I am now that my depression, fatigue, and extreme food sensitivities are pretty much resolved. I think the NA have been the most helpful for me, with TSO as a great backup.” [https://www.facebook.com/groups/htsupport/permalink/2490868600969080/?comment_id=2491288504260423]<!-- LNS -->		* “I’ve had so much success from the two types of friends... it’s the miracle I’ve been searching for (for 18 years) since 2001. I can’t even tell you how much happier I am now that my depression, fatigue, and extreme food sensitivities are pretty much resolved. I think the NA have been the most helpful for me, with TSO as a great backup.” (FB, [https://www.facebook.com/groups/htsupport/permalink/2490868600969080/?comment_id=2491288504260423 Nov 2019])<!-- LNS -->

	* "I’ve been previously diagnosed with depression, anxiety, PTSD, panic disorder, and a mood disorder, and for 10 or more years, life had seemed like a foggy dream. But after almost two years with NA, I realized that HT has significantly helped me with my mental health. It’s given me a sense of clarity that I haven’t had in years. I continue to require therapy as needed, and I’ve been treated with a wide range of medications over the years, but I’m currently only on one anxiety medication. I continue to be so thankful for HT. It’s life altering." (Edited from this post: [https://www.facebook.com/groups/htsupport/permalink/3610564992332763/].)<!-- CT -->		* "I’ve been previously diagnosed with depression, anxiety, PTSD, panic disorder, and a mood disorder, and for 10 or more years, life had seemed like a foggy dream. But after almost two years with NA, I realized that HT has significantly helped me with my mental health. It’s given me a sense of clarity that I haven’t had in years. I continue to require therapy as needed, and I’ve been treated with a wide range of medications over the years, but I’m currently only on one anxiety medication. I continue to be so thankful for HT. It’s life altering." (Edited from this post: (FB, [https://www.facebook.com/groups/htsupport/permalink/3610564992332763/ Feb 2021]).)<!-- CT -->

	* “I am pretty sure that my NA have dealt with my insomnia, probably part of what remains the biggest, and unexpected, benefit of taking on these wonderful companion animals: an end to depression and anxiety of a level such that I had to take tricyclic antidepressants to function.” [https://www.facebook.com/groups/htsupport/posts/4465083816880872/?comment_id=4467760283279892]<!-- RD -->		* “I am pretty sure that my NA have dealt with my insomnia, probably part of what remains the biggest, and unexpected, benefit of taking on these wonderful companion animals: an end to depression and anxiety of a level such that I had to take tricyclic antidepressants to function.” (FB, [https://www.facebook.com/groups/htsupport/posts/4465083816880872/?comment_id=4467760283279892 Nov 2021])<!-- RD -->

	* "TSO was the magic mood machine for me." [https://www.facebook.com/groups/htsupport/posts/5219928144729765?comment_id=5220568117999101&reply_comment_id=5221503187905594]<!-- LF -->		* "TSO was the magic mood machine for me." (FB, [https://www.facebook.com/groups/htsupport/posts/5219928144729765?comment_id=5220568117999101&reply_comment_id=5221503187905594 Aug 2022])<!-- LF -->

	* "I've been doing HDC for five months now. Started with five every three weeks. I expected no results for at least a week, but noticed an improvement in energy and mood in two days. While mood and energy are up, joint pain is down." [https://www.facebook.com/groups/htsupport/posts/4470230976366156?comment_id=5507026999353210]<!-- BD -->		* "I've been doing HDC for five months now. Started with five every three weeks. I expected no results for at least a week, but noticed an improvement in energy and mood in two days. While mood and energy are up, joint pain is down." [https://www.facebook.com/groups/htsupport/posts/4470230976366156?comment_id=5507026999353210]<!-- BD -->

	* "My mental health has been way better since starting helminth as I was pretty low on and off for a long time before that and especially bad when I was low in energy or sick, like when I had covid. After dosing with 3 NA, then 5, and now 3 NA every 3 months, I haven’t experienced that depression except for 1 day following another covid infection. I’m feeling like seeing people which I couldn’t face last year until well down the track." (~~Edited from~~ [https://www.facebook.com/groups/htsupport/posts/6271627282893174/ ~~this post~~].)<!-- SJ -->		* "My mental health has been way better since starting helminth as I was pretty low on and off for a long time before that and especially bad when I was low in energy or sick, like when I had covid. After dosing with 3 NA, then 5, and now 3 NA every 3 months, I haven’t experienced that depression except for 1 day following another covid infection. I’m feeling like seeing people which I couldn’t face last year until well down the track."(FB, [https://www.facebook.com/groups/htsupport/posts/6271627282893174/ Jul 2023])<!-- SJ -->

	===Temporarily ''increased'' depression===		===Temporarily ''increased'' depression===
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	{{Quote\|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}		{{Quote\|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}

	{{Quote\|indent}}I have hit a patch of depression here at week 9 of my first inoculation with 3NA and I am feeling very bleak. [https://www.facebook.com/groups/htsupport/permalink/1814806755241938/]{{Quote\|/indent}}		{{Quote\|indent}}I have hit a patch of depression here at week 9 of my first inoculation with 3NA and I am feeling very bleak. (FB, [https://www.facebook.com/groups/htsupport/permalink/1814806755241938/ Sep 2018]){{Quote\|/indent}}

	{{Quote\|indent}}I also feel quite depressed, will be 9 weeks for me on Tuesday. [https://www.facebook.com/groups/htsupport/permalink/1814806755241938/?comment_id=1815580378497909&comment_tracking=%7B%22tn%22%3A%22R0%22%7D]{{Quote\|/indent}}		{{Quote\|indent}}I also feel quite depressed, will be 9 weeks for me on Tuesday. (FB, [https://www.facebook.com/groups/htsupport/permalink/1814806755241938/?comment_id=1815580378497909&comment_tracking=%7B%22tn%22%3A%22R0%22%7D Sep 2018]){{Quote\|/indent}}

	{{Quote\|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}		{{Quote\|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}
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	{{Quote\|indent}}I experience plummeting mood following an NA inoculation. Dosing amounts are important with NA. [https://www.facebook.com/groups/htsupport/permalink/1936169449772334/?comment_id=1936702619719017&reply_comment_id=1936765523046060&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}		{{Quote\|indent}}I experience plummeting mood following an NA inoculation. Dosing amounts are important with NA. [https://www.facebook.com/groups/htsupport/permalink/1936169449772334/?comment_id=1936702619719017&reply_comment_id=1936765523046060&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}

	{{Quote\|indent}}When I used HDC, I found that a high dose made me agitated, where a low dose would lift my depression within hours from the moment of taking it. [https://www.facebook.com/groups/htsupport/posts/6666593640063201/?comment_id=6666843226704909]{{Quote\|/indent}}<!-- KE-A/KL/KG -->		{{Quote\|indent}}When I used HDC, I found that a high dose made me agitated, where a low dose would lift my depression within hours from the moment of taking it. (FB, [https://www.facebook.com/groups/htsupport/posts/6666593640063201/?comment_id=6666843226704909 Oct 2023]){{Quote\|/indent}}<!-- KE-A/KL/KG -->

	{{Quote\|indent}}My wife, who suffers from clinical depression, took 1 NA each month for 3 months. Then the Dr. told her to take 5 at once despite us asking multiple times if this would cause depression. We were told no each time. So my wife took the 5 at once as the doctor had suggested. A few days later, she began to get depressed and could not get out of bed for about 7-10 days. Cried all day. We killed the colony about 4 days later to prevent my wife from going to hospital because the depression was that bad. It was about another 2 weeks before she felt better again. (Edited from two posts: [https://www.facebook.com/groups/htsupport/posts/4830265563696027/?comment_id=5217548054967774] [https://www.facebook.com/groups/htsupport/posts/5219928144729765?comment_id=5220044041384842&reply_comment_id=5220058691383377].){{Quote\|/indent}}<!-- DK -->		{{Quote\|indent}}My wife, who suffers from clinical depression, took 1 NA each month for 3 months. Then the Dr. told her to take 5 at once despite us asking multiple times if this would cause depression. We were told no each time. So my wife took the 5 at once as the doctor had suggested. A few days later, she began to get depressed and could not get out of bed for about 7-10 days. Cried all day. We killed the colony about 4 days later to prevent my wife from going to hospital because the depression was that bad. It was about another 2 weeks before she felt better again. (Edited from two posts: (FB, [https://www.facebook.com/groups/htsupport/posts/4830265563696027/?comment_id=5217548054967774 Aug 2022]) (FB, [https://www.facebook.com/groups/htsupport/posts/5219928144729765?comment_id=5220044041384842&reply_comment_id=5220058691383377 Aug 2022]).){{Quote\|/indent}}<!-- DK -->

	{{Quote\|indent}}3.5 years in, I now have times where I even feel positive and optimistic, which is a huge improvement over a lifetime of clinical depression. But it’s also the first symptom to return, especially if I take a dose of NA that’s a little too much. Last dose was 7, and 3 days later I started 9 days of deep despair. I know it’s temporary, so I just hang on and get through it, but now I know 7 is too many. [https://www.facebook.com/groups/htsupport/permalink/1936169449772334/?comment_id=1936702619719017&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}		{{Quote\|indent}}3.5 years in, I now have times where I even feel positive and optimistic, which is a huge improvement over a lifetime of clinical depression. But it’s also the first symptom to return, especially if I take a dose of NA that’s a little too much. Last dose was 7, and 3 days later I started 9 days of deep despair. I know it’s temporary, so I just hang on and get through it, but now I know 7 is too many. [https://www.facebook.com/groups/htsupport/permalink/1936169449772334/?comment_id=1936702619719017&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote\|/indent}}

← Older revision		Revision as of 06:58, 12 November 2026
(4 intermediate revisions by the same user not shown)
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	* 2025 Oct 17 [https://open.fau.de/items/6b4e9f08-8bcc-4978-a15e-2c658a81450b Type 2 immunity and activation of STAT6 signaling in different disease models in lung and intestine] (Thesis, Erlangen-Nürnberg)		* 2025 Oct 17 [https://open.fau.de/items/6b4e9f08-8bcc-4978-a15e-2c658a81450b Type 2 immunity and activation of STAT6 signaling in different disease models in lung and intestine] (Thesis, Erlangen-Nürnberg)
	* 2024 Nov 10 [https://open.fau.de/items/b3704bc3-6f92-4352-8d03-ba61d7763455 Innate mechanisms in type 2 immunity-mediated lung inflammation] (Thesis, Erlangen-Nürnberg)		* 2024 Nov 10 [https://open.fau.de/items/b3704bc3-6f92-4352-8d03-ba61d7763455 Innate mechanisms in type 2 immunity-mediated lung inflammation] (Thesis, Erlangen-Nürnberg)
			* 2024 Dec 31 [https://pubmed.ncbi.nlm.nih.gov/39796136/ The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect]
	* 2024 Nov 3 [https://pubmed.ncbi.nlm.nih.gov/39489845/ Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis]		* 2024 Nov 3 [https://pubmed.ncbi.nlm.nih.gov/39489845/ Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis]
	* 2024 Jul [https://pubmed.ncbi.nlm.nih.gov/39073185/ The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11331508/ Full text] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11331508/pdf/nihms-2007521.pdf PDF~~]		* 2024 Jul [https://pubmed.ncbi.nlm.nih.gov/39073185/ The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6]
	* 2024 [https://repository.upenn.edu/entities/publication/c331d27e-8c54-4b8b-8e00-883cd6f5f09b Hookworms dynamically respond to loss of Type 2 immune pressure] (Thesis)		* 2024 [https://repository.upenn.edu/entities/publication/c331d27e-8c54-4b8b-8e00-883cd6f5f09b Hookworms dynamically respond to loss of Type 2 immune pressure] (Thesis)
	* 2023 Dec 11 [https://pubmed.ncbi.nlm.nih.gov/38079450/ Hookworms dynamically respond to loss of Type 2 immune pressure]		* 2023 Dec 11 [https://pubmed.ncbi.nlm.nih.gov/38079450/ Hookworms dynamically respond to loss of Type 2 immune pressure]
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	* 2023 Mar 30 [https://open.fau.de/items/5a1b683a-a8ad-4d5a-b6f6-e05e0d847a49 Regulation of the humoral type 2 immune response] (Thesis, Erlangen-Nürnberg)		* 2023 Mar 30 [https://open.fau.de/items/5a1b683a-a8ad-4d5a-b6f6-e05e0d847a49 Regulation of the humoral type 2 immune response] (Thesis, Erlangen-Nürnberg)
	* 2022 Jun 6 [https://open.fau.de/items/5542424a-d37a-4853-9543-6d96e1517b97 STAT6 regulated B cell responses] (Thesis, Erlangen-Nürnberg)		* 2022 Jun 6 [https://open.fau.de/items/5542424a-d37a-4853-9543-6d96e1517b97 STAT6 regulated B cell responses] (Thesis, Erlangen-Nürnberg)
	* 2021 Feb [https://pubmed.ncbi.nlm.nih.gov/33067820/ Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice~~] -- [https://onlinelibrary.wiley.com/doi/10.1002/eji.201848072 Full text~~]		* 2021 Feb [https://pubmed.ncbi.nlm.nih.gov/33067820/ Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice]
	* 2020 Mar 2 [https://open.fau.de/items/b0549105-a51b-41e8-8bac-3722522c6209 The role of STAT6-regulated gene expression in macrophages and epithelial cells in the context of helminth infections] (Thesis, Erlangen-Nürnberg)		* 2020 Mar 2 [https://open.fau.de/items/b0549105-a51b-41e8-8bac-3722522c6209 The role of STAT6-regulated gene expression in macrophages and epithelial cells in the context of helminth infections] (Thesis, Erlangen-Nürnberg)
	* 2019 Sep [https://pubmed.ncbi.nlm.nih.gov/31144294/ Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice]		* 2019 Sep [https://pubmed.ncbi.nlm.nih.gov/31144294/ Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice]
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	* 2019 Jan [https://pubmed.ncbi.nlm.nih.gov/30194773/ STAT6 and IL-10 are required for the anti-arthritic effects of Schistosoma mansoni via different mechanisms]		* 2019 Jan [https://pubmed.ncbi.nlm.nih.gov/30194773/ STAT6 and IL-10 are required for the anti-arthritic effects of Schistosoma mansoni via different mechanisms]
	* 2017 Aug [https://escholarship.mcgill.ca/concern/theses/np193c315 Evaluating type 2 immune responses during gastrointestinal nematode infection using a STAT6 inhibitor] (Thesis, McGill)		* 2017 Aug [https://escholarship.mcgill.ca/concern/theses/np193c315 Evaluating type 2 immune responses during gastrointestinal nematode infection using a STAT6 inhibitor] (Thesis, McGill)
	* 2017 Jun [https://pubmed.ncbi.nlm.nih.gov/28363777/ Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice~~] -- [https://www.sciencedirect.com/science/article/abs/pii/S0014489417301728?via%3Dihub Full text~~]		* 2017 Jun [https://pubmed.ncbi.nlm.nih.gov/28363777/ Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice]
	* 2010 Dec 28 [https://pubmed.ncbi.nlm.nih.gov/21149710/ IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity]		* 2010 Dec 28 [https://pubmed.ncbi.nlm.nih.gov/21149710/ IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity]
	* 2010 Oct 28 [https://pubmed.ncbi.nlm.nih.gov/20625006/ Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2]		* 2010 Oct 28 [https://pubmed.ncbi.nlm.nih.gov/20625006/ Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2]
	* 2009 Aug [https://pubmed.ncbi.nlm.nih.gov/19535141/ The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri~~] -- [https://openresearch-repository.anu.edu.au/server/api/core/bitstreams/fe2c741a-90fe-41f5-b5d4-94359eb317ea/content PDF~~]		* 2009 Aug [https://pubmed.ncbi.nlm.nih.gov/19535141/ The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri]
	* 2004 May 1 [https://pubmed.ncbi.nlm.nih.gov/15100305/ Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function]		* 2004 May 1 [https://pubmed.ncbi.nlm.nih.gov/15100305/ Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function]
	* 2003 Feb [https://pubmed.ncbi.nlm.nih.gov/12659328/ STAT-6 is an absolute requirement for murine rejection of Hymenolepis diminuta]		* 2003 Feb [https://pubmed.ncbi.nlm.nih.gov/12659328/ STAT-6 is an absolute requirement for murine rejection of Hymenolepis diminuta]
	* 2001 Dec [https://pubmed.ncbi.nlm.nih.gov/11705956/ Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite]		* 2001 Dec [https://pubmed.ncbi.nlm.nih.gov/11705956/ Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite]
	* 2000 Feb 15 [https://pubmed.ncbi.nlm.nih.gov/10657657/ Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism]		* 2000 Feb 15 [https://pubmed.ncbi.nlm.nih.gov/10657657/ Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism]
	* 1998 Feb [https://pubmed.ncbi.nlm.nih.gov/9492006/ IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis~~] -- [https://www.cell.com/fulltext/S1074-7613(00)80477-X Full text~~]		* 1998 Feb [https://pubmed.ncbi.nlm.nih.gov/9492006/ IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis]
	* 1996 Apr 18 [https://pubmed.ncbi.nlm.nih.gov/8602263/ Essential role of Stat6 in IL-4 signalling]		* 1996 Apr 18 [https://pubmed.ncbi.nlm.nih.gov/8602263/ Essential role of Stat6 in IL-4 signalling]

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	* 2026 Sep 22 [https://www.dovepress.com/the-multifaceted-roles-of-stat6-implications-for-precision-immunothera-peer-reviewed-fulltext-article-ITT The Multifaceted Roles of STAT6: Implications for Precision Immunotherapeutics]		* 2026 Sep 22 [https://www.dovepress.com/the-multifaceted-roles-of-stat6-implications-for-precision-immunothera-peer-reviewed-fulltext-article-ITT The Multifaceted Roles of STAT6: Implications for Precision Immunotherapeutics]
			* 2026 Mar 16 [https://pubmed.ncbi.nlm.nih.gov/41838170/ STAT6: Multidimensional analysis from hematopoietic immune regulation to pathogenesis mechanisms and therapeutic targets in hematologic malignancies]
	* 2026 Feb 24 [https://pubmed.ncbi.nlm.nih.gov/41735318/ DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence]		* 2026 Feb 24 [https://pubmed.ncbi.nlm.nih.gov/41735318/ DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence]
	* 2026 Feb 20 [https://www.biorxiv.org/content/10.64898/2026.02.19.706676v1 Mechanosensing and IL-13 Signaling Synergistically Modulate Intestinal Stem Cell Differentiation via STAT6 and YAP] (Preprint)		* 2026 Feb 20 [https://www.biorxiv.org/content/10.64898/2026.02.19.706676v1 Mechanosensing and IL-13 Signaling Synergistically Modulate Intestinal Stem Cell Differentiation via STAT6 and YAP] (Preprint)
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	* 2018 Oct 31 [https://pubmed.ncbi.nlm.nih.gov/30379806 The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections]		* 2018 Oct 31 [https://pubmed.ncbi.nlm.nih.gov/30379806 The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections]
	* 2018 Oct 30 [https://pubmed.ncbi.nlm.nih.gov/30375396/ Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection]		* 2018 Oct 30 [https://pubmed.ncbi.nlm.nih.gov/30375396/ Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection]
			* 2018 Oct 5 [https://pubmed.ncbi.nlm.nih.gov/30291167/ Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells]
	* 2018 Sep 21 [https://pubmed.ncbi.nlm.nih.gov/30238872/ Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion]		* 2018 Sep 21 [https://pubmed.ncbi.nlm.nih.gov/30238872/ Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion]
	* 2018 Sep 2 [https://helminthconference.org/wp-content/uploads/2023/05/2018-Hydra-Conference-Booklet.pdf Partial removal of IL-4 receptor alpha within the FoxP3+ regulatory T cell population impairs the control of inflammation in disease] (Conference)		* 2018 Sep 2 [https://helminthconference.org/wp-content/uploads/2023/05/2018-Hydra-Conference-Booklet.pdf Partial removal of IL-4 receptor alpha within the FoxP3+ regulatory T cell population impairs the control of inflammation in disease] (Conference)
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	* 2010 May [https://www.gastrojournal.org/article/S0016-5085(10)60071-6/fulltext Helminths Regulate Acute Graft Versus Host Disease and Colitis in a TGFβ Dependent Manner in Mice]		* 2010 May [https://www.gastrojournal.org/article/S0016-5085(10)60071-6/fulltext Helminths Regulate Acute Graft Versus Host Disease and Colitis in a TGFβ Dependent Manner in Mice]

	* 2009 Aug 1 [https://pubmed.ncbi.nlm.nih.gov/19587018/ Infection with a Helminth Parasite Attenuates Autoimmunity through TGF-β-Mediated Suppression of Th17 and Th1 Responses~~] -- [http://www.jimmunol.org/content/183/3/1577.long Full text] \| [http://www.jimmunol.org/content/183/3/1577.full.pdf PDF~~]		* 2009 Aug 1 [https://pubmed.ncbi.nlm.nih.gov/19587018/ Infection with a Helminth Parasite Attenuates Autoimmunity through TGF-β-Mediated Suppression of Th17 and Th1 Responses]

	* 2009 Jul [https://pubmed.ncbi.nlm.nih.gov/19544487/ Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation]		* 2009 Jul [https://pubmed.ncbi.nlm.nih.gov/19544487/ Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation]

	* 2008 Jul 23 [https://pubmed.ncbi.nlm.nih.gov/18554755/ Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production~~] -- [https://www.sciencedirect.com/science/article/abs/pii/S0264410X08005409 Full text~~]		* 2008 Jul 23 [https://pubmed.ncbi.nlm.nih.gov/18554755/ Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production]

	* 2007 Nov [https://pubmed.ncbi.nlm.nih.gov/17643432/ Schistosoma mansoni: TGF-beta signaling pathways]		* 2007 Nov [https://pubmed.ncbi.nlm.nih.gov/17643432/ Schistosoma mansoni: TGF-beta signaling pathways]
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	See also		See also

	* 2021 Mar [https://pubmed.ncbi.nlm.nih.gov/33446887/ Induced regulatory T cells suppress Tc1 cells through TGF-β signaling to ameliorate STZ-induced type 1 diabetes mellitus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8027661/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8027661/pdf/41423_2020_Article_623.pdf PDF~~]		* 2021 Mar [https://pubmed.ncbi.nlm.nih.gov/33446887/ Induced regulatory T cells suppress Tc1 cells through TGF-β signaling to ameliorate STZ-induced type 1 diabetes mellitus]
	* 2011 Jul [https://pubmed.ncbi.nlm.nih.gov/21469118/ TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3139176/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3139176/pdf/nihms-297864.pdf PDF~~]		* 2011 Jul [https://pubmed.ncbi.nlm.nih.gov/21469118/ TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function]
	* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18997793/ IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells]		* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18997793/ IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells]
	* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18931678/ Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset]		* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18931678/ Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset]
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	* 2017 Nov 28 [https://pubmed.ncbi.nlm.nih.gov/29133417 Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction]		* 2017 Nov 28 [https://pubmed.ncbi.nlm.nih.gov/29133417 Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction]

			* 2016 Aug [https://pubmed.ncbi.nlm.nih.gov/27420789/ Helminth Interaction with the Host Immune System: Short-Term Benefits and Costs in Relation to the Infectious Environment]

	* 2016 Jun 1 [https://pubmed.ncbi.nlm.nih.gov/27249227/ Usefulness of ELISA Methods for Assessing LPS Interactions with Proteins and Peptides]		* 2016 Jun 1 [https://pubmed.ncbi.nlm.nih.gov/27249227/ Usefulness of ELISA Methods for Assessing LPS Interactions with Proteins and Peptides]

← Older revision		Revision as of 21:52, 11 November 2026
(3 intermediate revisions by the same user not shown)
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	* 2020 Nov [https://pubmed.ncbi.nlm.nih.gov/32603502/ Characterization of ovine monocyte activity when cultured with Haemonchus contortus larvae in vitro]		* 2020 Nov [https://pubmed.ncbi.nlm.nih.gov/32603502/ Characterization of ovine monocyte activity when cultured with Haemonchus contortus larvae in vitro]

			* 2020 May 18 [https://pubmed.ncbi.nlm.nih.gov/32421753/ Trichinella spiralis-induced mastocytosis and erythropoiesis are simultaneously supported by a bipotent mast cell/erythrocyte precursor cell]

	* 2019 Dec 15 [https://openscholarship.wustl.edu/art_sci_etds/2004/ The Transcription Factor Bhlhe40 Regulates Tissue-Resident Macrophages and Type 2 Immunity] (Thesis, Washington)		* 2019 Dec 15 [https://openscholarship.wustl.edu/art_sci_etds/2004/ The Transcription Factor Bhlhe40 Regulates Tissue-Resident Macrophages and Type 2 Immunity] (Thesis, Washington)
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	* 2017 [https://ru.dgb.unam.mx/items/2c7ca65f-c206-499c-93ff-faa928c11da9 Reclutamiento temprano de monocitos y granulocitos por antígenos excretados/secretados de Taenia crassiceps] (Licence, Mexico, Spanish)		* 2017 [https://ru.dgb.unam.mx/items/2c7ca65f-c206-499c-93ff-faa928c11da9 Reclutamiento temprano de monocitos y granulocitos por antígenos excretados/secretados de Taenia crassiceps] (Licence, Mexico, Spanish)

			* 2016 Nov [https://pubmed.ncbi.nlm.nih.gov/27594558/ Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow]

	* 2016 Aug [https://pubmed.ncbi.nlm.nih.gov/27095802/ Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling]		* 2016 Aug [https://pubmed.ncbi.nlm.nih.gov/27095802/ Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling]
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	* 2015 Sep [https://pubmed.ncbi.nlm.nih.gov/26178310/ Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections]		* 2015 Sep [https://pubmed.ncbi.nlm.nih.gov/26178310/ Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections]

	* 2015 Jul 25 [http://pubmed.ncbi.nlm.nih.gov/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis~~] -- [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/ Full text] \| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/pdf/40478_2015_Article_223.pdf PDF~~]		* 2015 Jul 25 [http://pubmed.ncbi.nlm.nih.gov/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis]

	* 2015 Mar 9 [https://refubium.fu-berlin.de/handle/fub188/2727 Monocytes and macrophages as determinants of susceptibility to infection in lymphatic filariasis] (Thesis, Freie Berlin)		* 2015 Mar 9 [https://refubium.fu-berlin.de/handle/fub188/2727 Monocytes and macrophages as determinants of susceptibility to infection in lymphatic filariasis] (Thesis, Freie Berlin)
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	* 2024 Jul 6 [https://pubmed.ncbi.nlm.nih.gov/39000527/ Nematode Galectin Inhibits Basophilic Leukaemia RBL-2H3 Cells Apoptosis in IgE-Mediated Activation]		* 2024 Jul 6 [https://pubmed.ncbi.nlm.nih.gov/39000527/ Nematode Galectin Inhibits Basophilic Leukaemia RBL-2H3 Cells Apoptosis in IgE-Mediated Activation]
	* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)		* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/151.21/7947700 B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection] (Conference, Immunology2023, Washington)
			* 2020 May 18 [https://pubmed.ncbi.nlm.nih.gov/32421753/ Trichinella spiralis-induced mastocytosis and erythropoiesis are simultaneously supported by a bipotent mast cell/erythrocyte precursor cell]
	* 2020 Feb [https://pubmed.ncbi.nlm.nih.gov/31834940 Chronic infection with a tissue invasive helminth attenuates sublethal anaphylaxis and reduces granularity and number of mast cells]		* 2020 Feb [https://pubmed.ncbi.nlm.nih.gov/31834940 Chronic infection with a tissue invasive helminth attenuates sublethal anaphylaxis and reduces granularity and number of mast cells]
	* 2019 Feb 15 [https://pubmed.ncbi.nlm.nih.gov/30670631/ Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6379226/ Full text~~]		* 2019 Feb 15 [https://pubmed.ncbi.nlm.nih.gov/30670631/ Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response]
	* 2018 Nov 30 [https://pubmed.ncbi.nlm.nih.gov/30341242/ Mast cell deficiency in mice results in biomass overgrowth and delayed expulsion of the rat tapeworm Hymenolepis diminuta]		* 2018 Nov 30 [https://pubmed.ncbi.nlm.nih.gov/30341242/ Mast cell deficiency in mice results in biomass overgrowth and delayed expulsion of the rat tapeworm Hymenolepis diminuta]
	* 2018 Feb 13 [https://pubmed.ncbi.nlm.nih.gov/29444434/ B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade]		* 2018 Feb 13 [https://pubmed.ncbi.nlm.nih.gov/29444434/ B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade]
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	* 2024 Aug 13 [https://pubmed.ncbi.nlm.nih.gov/39096910/ The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response] (Comment: 2024 Aug 13 [https://pubmed.ncbi.nlm.nih.gov/39142272/ Wriggly woes: Helminths stirring up T cell trouble])		* 2024 Aug 13 [https://pubmed.ncbi.nlm.nih.gov/39096910/ The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response] (Comment: 2024 Aug 13 [https://pubmed.ncbi.nlm.nih.gov/39142272/ Wriggly woes: Helminths stirring up T cell trouble])
	* 2024 Feb [https://pubmed.ncbi.nlm.nih.gov/38101763/ Echinococcus granulosus cyst fluid inhibits the type I interferon response by promoting ROS in macrophages]		* 2024 Feb [https://pubmed.ncbi.nlm.nih.gov/38101763/ Echinococcus granulosus cyst fluid inhibits the type I interferon response by promoting ROS in macrophages]
			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/156.01/7947818 Enteric helminth infection confers protection against lethal respiratory influenza virus infection] (Conference, Immunology2023, Washington)
	* 2021 Nov 29 [https://research.manchester.ac.uk/en/studentTheses/characterising-the-peritoneal-and-hepatic-response-to-enteric-nem/ Characterising the peritoneal and hepatic response to enteric nematode infection] (Thesis, Manchester)		* 2021 Nov 29 [https://research.manchester.ac.uk/en/studentTheses/characterising-the-peritoneal-and-hepatic-response-to-enteric-nem/ Characterising the peritoneal and hepatic response to enteric nematode infection] (Thesis, Manchester)
	* 2019 Aug [https://pubmed.ncbi.nlm.nih.gov/31099896/ Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs]		* 2019 Aug [https://pubmed.ncbi.nlm.nih.gov/31099896/ Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs]

← Older revision		Revision as of 21:18, 11 November 2026
(2 intermediate revisions by the same user not shown)
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	* 2025 Aug 15 [https://pubmed.ncbi.nlm.nih.gov/40895302/ IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells]		* 2025 Aug 15 [https://pubmed.ncbi.nlm.nih.gov/40895302/ IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells]

	* 2025 Jul 8 [https://pubmed.ncbi.nlm.nih.gov/40626733/ Ascaris Lumbricoides Cystatin Impairs IL-1β Maturation and CD14 Expression in Human Monocytes~~] -- [https://onlinelibrary.wiley.com/doi/10.1111/imm.70016 Full text~~]		* 2025 Jul 8 [https://pubmed.ncbi.nlm.nih.gov/40626733/ Ascaris Lumbricoides Cystatin Impairs IL-1β Maturation and CD14 Expression in Human Monocytes]

	* 2024 Aug [https://pubmed.ncbi.nlm.nih.gov/38924546/ Helminth induced monocytosis conveys protection from respiratory syncytial virus infection in mice~~] -- [https://onlinelibrary.wiley.com/doi/10.1111/all.16206 Full text~~]		* 2024 Aug [https://pubmed.ncbi.nlm.nih.gov/38924546/ Helminth induced monocytosis conveys protection from respiratory syncytial virus infection in mice]

	* 2023 Dec [https://pubmed.ncbi.nlm.nih.gov/36797216/ Modulation of haematopoiesis by protozoal and helminth parasites]		* 2023 Dec [https://pubmed.ncbi.nlm.nih.gov/36797216/ Modulation of haematopoiesis by protozoal and helminth parasites]

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/72.36/7946182 IL-4 receptor signaling regulates lung macrophages during helminth coinfection resulting in enhanced gammaherpesvirus permissiveness] (Conference, Immunology2023, Washington)

	* 2022 Aug [https://pubmed.ncbi.nlm.nih.gov/35649322/ Antigens from the parasitic nematode Trichuris suis induce metabolic reprogramming and trained immunity to constrain inflammatory responses in macrophages]		* 2022 Aug [https://pubmed.ncbi.nlm.nih.gov/35649322/ Antigens from the parasitic nematode Trichuris suis induce metabolic reprogramming and trained immunity to constrain inflammatory responses in macrophages]
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	* 2021 Apr 1 [https://pubmed.ncbi.nlm.nih.gov/33579723/ Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease]		* 2021 Apr 1 [https://pubmed.ncbi.nlm.nih.gov/33579723/ Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease]

	* 2021 Mar 2 [https://pubmed.ncbi.nlm.nih.gov/33651797/ Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC7954301/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC7954301/pdf/pntd.0009194.pdf PDF~~]		* 2021 Mar 2 [https://pubmed.ncbi.nlm.nih.gov/33651797/ Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis]

	* 2021 Feb [https://pubmed.ncbi.nlm.nih.gov/33415398/ Regulation of human THP-1 macrophage polarization by Trichinella spiralis]		* 2021 Feb [https://pubmed.ncbi.nlm.nih.gov/33415398/ Regulation of human THP-1 macrophage polarization by Trichinella spiralis]
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	* 2024 Mar 7 [https://scholarlypublications.universiteitleiden.nl/handle/1887/3719960 AMPK signaling in dendritic cells: a metabolic sensor controlling the balance between immunity and tolerance] (Thesis, Leiden)		* 2024 Mar 7 [https://scholarlypublications.universiteitleiden.nl/handle/1887/3719960 AMPK signaling in dendritic cells: a metabolic sensor controlling the balance between immunity and tolerance] (Thesis, Leiden)
	* 2023 May 19 [https://pubmed.ncbi.nlm.nih.gov/37274316/ Notch signaling pathway involved in Echinococcus granulosus infection regulates dendritic cell development and differentiation]		* 2023 May 19 [https://pubmed.ncbi.nlm.nih.gov/37274316/ Notch signaling pathway involved in Echinococcus granulosus infection regulates dendritic cell development and differentiation]
	* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.10/7947016 CD301b+ DCs orchestrate type 2 immune responses to helminth infection in the lung]		* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.10/7947016 CD301b+ DCs orchestrate type 2 immune responses to helminth infection in the lung] (Conference, Immunology2023, Washington)
	* 2022 May 26 [https://pubmed.ncbi.nlm.nih.gov/35720355/ Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice]		* 2022 May 26 [https://pubmed.ncbi.nlm.nih.gov/35720355/ Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice]
	* 2022 Feb 23 [https://scholarlypublications.universiteitleiden.nl/handle/1887/3275848 Role of metabolic pathways and sensors in regulation of dendritic cell-driven T cell responses] (Thesis, Leiden)		* 2022 Feb 23 [https://scholarlypublications.universiteitleiden.nl/handle/1887/3275848 Role of metabolic pathways and sensors in regulation of dendritic cell-driven T cell responses] (Thesis, Leiden)
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	* 2023 Jul 7 [https://ediss.sub.uni-hamburg.de/handle/ediss/10381 The role of CD160 in the immune response against worm infections] (Thesis, Hamburg, German)		* 2023 Jul 7 [https://ediss.sub.uni-hamburg.de/handle/ediss/10381 The role of CD160 in the immune response against worm infections] (Thesis, Hamburg, German)

			* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/72.30/7946188 Determining the fate of pulmonary iILC2s in helminth infection] (Conference, Immunology2023, Washington)

	* 2023 Mar 31 [https://pubmed.ncbi.nlm.nih.gov/37063913/ ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses]		* 2023 Mar 31 [https://pubmed.ncbi.nlm.nih.gov/37063913/ ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses]

← Older revision		Revision as of 21:10, 11 November 2026
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	* 2025 Oct 13 [https://pubmed.ncbi.nlm.nih.gov/41082564/ Characterization and ligand binding properties of a fatty acid- and retinol- binding protein (Hp-FAR-2) from Heligmosomoides polygyrus]		* 2025 Oct 13 [https://pubmed.ncbi.nlm.nih.gov/41082564/ Characterization and ligand binding properties of a fatty acid- and retinol- binding protein (Hp-FAR-2) from Heligmosomoides polygyrus]
	* 2025 Jul 18 [https://pubmed.ncbi.nlm.nih.gov/40725160/ Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages]		* 2025 Jul 18 [https://pubmed.ncbi.nlm.nih.gov/40725160/ Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages]
	* 2025 May 29 [https://pubmed.ncbi.nlm.nih.gov/40497975/ Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12153920/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12153920/pdf/cells-14-00799.pdf PDF~~]		* 2025 May 29 [https://pubmed.ncbi.nlm.nih.gov/40497975/ Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model]
	* 2025 Jan 17 [https://pubmed.ncbi.nlm.nih.gov/39823413/ Nb-FAR-1: A key developmental protein affects lipid droplet accumulation and cuticle formation in Nippostrongylus brasiliensis~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11741380/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11741380/pdf/pntd.0012769.pdf PDF~~]		* 2025 Jan 17 [https://pubmed.ncbi.nlm.nih.gov/39823413/ Nb-FAR-1: A key developmental protein affects lipid droplet accumulation and cuticle formation in Nippostrongylus brasiliensis]
	* 2025 [https://escholarship.org/uc/item/6cj469h6 Exploring the Role of Fatty Acids in Nematode Parasitism and Insect Immunity] (Thesis, California)		* 2025 [https://escholarship.org/uc/item/6cj469h6 Exploring the Role of Fatty Acids in Nematode Parasitism and Insect Immunity] (Thesis, California)
	* 2024 Jul 10 [https://sedici.unlp.edu.ar/handle/10915/168160 Análisis funcional de proteínas que unen ácidos grasos y retinol (FAR) pertenecientes al phylum Nematoda] (Thesis) (Spanish)		* 2024 Jul 10 [https://sedici.unlp.edu.ar/handle/10915/168160 Análisis funcional de proteínas que unen ácidos grasos y retinol (FAR) pertenecientes al phylum Nematoda] (Thesis) (Spanish)
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	* 2023 Jul 10 [https://pubmed.ncbi.nlm.nih.gov/37430357/ Fatty acid- and retinol-binding protein 6 does not control worm fatty acid content in Caenorhabditis elegans but might play a role in Haemonchus contortus parasitism]		* 2023 Jul 10 [https://pubmed.ncbi.nlm.nih.gov/37430357/ Fatty acid- and retinol-binding protein 6 does not control worm fatty acid content in Caenorhabditis elegans but might play a role in Haemonchus contortus parasitism]
	* 2023 Jun 26 [https://pubmed.ncbi.nlm.nih.gov/37363916/ Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells]		* 2023 Jun 26 [https://pubmed.ncbi.nlm.nih.gov/37363916/ Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells]
	* 2022 May 26 [https://pubmed.ncbi.nlm.nih.gov/35720355/ Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice] -- [https://~~pmc~~.~~ncbi.nlm.nih~~.~~gov~~/~~articles~~/~~PMC9204345~~/ ~~Full text] \| [https:~~//~~pmc.ncbi~~.~~nlm.nih.gov~~/~~articles/PMC9204345/pdf/fimmu-13-884663.pdf PDF~~]		* 2022 May 26 [https://pubmed.ncbi.nlm.nih.gov/35720355/ Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice]
	* 2022 Apr 21 [https://pubmed.ncbi.nlm.nih.gov/35446920/ The FAR protein family of parasitic nematodes~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC9022830/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC9022830/pdf/ppat.1010424.pdf PDF~~]		* 2023 May [https://academic.oup.com/jimmunol/article-abstract/210/Supplement_1/82.02/7946922 Fasciola hepatica Fh15 promote survival in a mouse septic shock model and downregulates inflammatory cytokines] (Conference, Immunology2023, Washington)
	* 2021 Dec 22 [https://pubmed.ncbi.nlm.nih.gov/34937173/ Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8694124/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8694124/pdf/spectrum.01910-21.pdf PDF~~]		* 2022 Apr 21 [https://pubmed.ncbi.nlm.nih.gov/35446920/ The FAR protein family of parasitic nematodes]
	* 2021 Dec [https://pubmed.ncbi.nlm.nih.gov/34752732/ Fasciola hepatica fatty acid binding protein (Fh12) induces apoptosis and tolerogenic properties in murine bone marrow derived dendritic cells~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC9144297/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC9144297/pdf/nihms-1803623.pdf PDF~~]		* 2021 Dec 22 [https://pubmed.ncbi.nlm.nih.gov/34937173/ Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model]
	* 2021 Oct 29 [https://pubmed.ncbi.nlm.nih.gov/34714893/ Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8580252/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8580252/pdf/ppat.1010027.pdf PDF~~]		* 2021 Dec [https://pubmed.ncbi.nlm.nih.gov/34752732/ Fasciola hepatica fatty acid binding protein (Fh12) induces apoptosis and tolerogenic properties in murine bone marrow derived dendritic cells]
	* 2021 Sep 17 [https://pubmed.ncbi.nlm.nih.gov/34576221/ Novel Functions of the Fatty Acid and Retinol Binding Protein (FAR) Gene Family Revealed by Fungus-Mediated RNAi in the Parasitic Nematode, Aphelenchoides besseyi~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8471444/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8471444/pdf/ijms-22-10057.pdf PDF~~]		* 2021 Oct 29 [https://pubmed.ncbi.nlm.nih.gov/34714893/ Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways]
	* 2021 Aug 30 [https://pubmed.ncbi.nlm.nih.gov/34461887/ Genus-level evolutionary relationships of FAR proteins reflect the diversity of lifestyles of free-living and parasitic nematodes~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8407040/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8407040/pdf/12915_2021_Article_1111.pdf PDF~~]		* 2021 Sep 17 [https://pubmed.ncbi.nlm.nih.gov/34576221/ Novel Functions of the Fatty Acid and Retinol Binding Protein (FAR) Gene Family Revealed by Fungus-Mediated RNAi in the Parasitic Nematode, Aphelenchoides besseyi]
			* 2021 Aug 30 [https://pubmed.ncbi.nlm.nih.gov/34461887/ Genus-level evolutionary relationships of FAR proteins reflect the diversity of lifestyles of free-living and parasitic nematodes]
	* 2021 Aug [https://www.proquest.com/openview/49ce7153242abb1b34c1694fe55cf06a/1?pq-origsite=gscholar&cbl=18750&diss=y Testing the Efficacy of Fh15, a Recombinant Fatty Acid Binding Protein from Fasciola hepatica, as a Novel Anti-Inflammatory Biotherapeutic in an Acute Gram-Negative Non-Human Primate Sepsis Model] (Thesis)		* 2021 Aug [https://www.proquest.com/openview/49ce7153242abb1b34c1694fe55cf06a/1?pq-origsite=gscholar&cbl=18750&diss=y Testing the Efficacy of Fh15, a Recombinant Fatty Acid Binding Protein from Fasciola hepatica, as a Novel Anti-Inflammatory Biotherapeutic in an Acute Gram-Negative Non-Human Primate Sepsis Model] (Thesis)
	* 2021 Jul [https://pubmed.ncbi.nlm.nih.gov/33993100/ The fatty acid-binding protein (FABP) decreases the clinical signs and modulates immune responses in a mouse model of experimental autoimmune encephalomyelitis (EAE)~~] -- [https://www.sciencedirect.com/science/article/abs/pii/S1567576921003921 Full text~~]		* 2021 Jul [https://pubmed.ncbi.nlm.nih.gov/33993100/ The fatty acid-binding protein (FABP) decreases the clinical signs and modulates immune responses in a mouse model of experimental autoimmune encephalomyelitis (EAE)]
	* 2021 [https://escholarship.org/uc/item/7m993118 The Roles of Parasitic Nematode Effectors on Host Immunity and Lipid Signaling] (Thesis, California)		* 2021 [https://escholarship.org/uc/item/7m993118 The Roles of Parasitic Nematode Effectors on Host Immunity and Lipid Signaling] (Thesis, California)
	* 2020 Oct [https://pubmed.ncbi.nlm.nih.gov/32961509/ HcFAR, a functional inhibitor of goat TGF-β1 identified from excretory and secretory products of Haemonchus contortus]		* 2020 Oct [https://pubmed.ncbi.nlm.nih.gov/32961509/ HcFAR, a functional inhibitor of goat TGF-β1 identified from excretory and secretory products of Haemonchus contortus]
	* 2020 [https://pubmed.ncbi.nlm.nih.gov/32399927/ Purification of Native Fasciola hepatica Fatty Acid-Binding Protein and Induction of Alternative Activation of Human Macrophages] (Book chapter of Fasciola hepatica: Methods and Protocols)		* 2020 [https://pubmed.ncbi.nlm.nih.gov/32399927/ Purification of Native Fasciola hepatica Fatty Acid-Binding Protein and Induction of Alternative Activation of Human Macrophages] (Book chapter of Fasciola hepatica: Methods and Protocols)
	* 2019 Aug 26 [https://pubmed.ncbi.nlm.nih.gov/31365253/ Fatty Acid and Retinol-Binding Protein: Unusual Protein Conformational and Cavity Changes Dictated by Ligand Fluctuations] -- [https://ri.conicet.gov.ar/handle/11336/131023 Full text] \| [https://ri.conicet.gov.ar/bitstream/handle/11336/131023/CONICET_Digital_Nro.ebda6bdc-3cdd-41cc-8ec9-500ad550c64a_A.pdf?sequence=2&isAllowed=y PDF]		* 2019 Aug 26 [https://pubmed.ncbi.nlm.nih.gov/31365253/ Fatty Acid and Retinol-Binding Protein: Unusual Protein Conformational and Cavity Changes Dictated by Ligand Fluctuations]
	* 2018 Sep 2 [https://helminthconference.org/wp-content/uploads/2023/05/2018-Hydra-Conference-Booklet.pdf Fatty acid binding proteins (FABP) of parasitic cestodes: functional studies and evaluation as novel therapeutic targets]		* 2018 Sep 2 [https://helminthconference.org/wp-content/uploads/2023/05/2018-Hydra-Conference-Booklet.pdf Fatty acid binding proteins (FABP) of parasitic cestodes: functional studies and evaluation as novel therapeutic targets]
	* 2017 Oct [https://theses.gla.ac.uk/8997/ Biochemical and structural characterisation of human phosphatidylinositol transfer protein Nir2 and American hookworm lipid binding protein Na-FAR-1] (Thesis, Glasgow)		* 2017 Oct [https://theses.gla.ac.uk/8997/ Biochemical and structural characterisation of human phosphatidylinositol transfer protein Nir2 and American hookworm lipid binding protein Na-FAR-1] (Thesis, Glasgow)
	* 2017 Jul 14 [https://pubmed.ncbi.nlm.nih.gov/28710478/ Recombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC5511235/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC5511235/pdf/41598_2017_Article_5735.pdf PDF~~]		* 2017 Jul 14 [https://pubmed.ncbi.nlm.nih.gov/28710478/ Recombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands]
	* 2017 Mar 31 [https://pmc.ncbi.nlm.nih.gov/articles/PMC5690573/ Fasciola hepatica ESPs Could Indistinctly Activate or Block Multiple Toll-Like Receptors in a Human Monocyte Cell Line]		* 2017 Mar 31 [https://pmc.ncbi.nlm.nih.gov/articles/PMC5690573/ Fasciola hepatica ESPs Could Indistinctly Activate or Block Multiple Toll-Like Receptors in a Human Monocyte Cell Line]
	* 2016 Sep 2 [https://pubmed.ncbi.nlm.nih.gov/27495901/ Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species]		* 2016 Sep 2 [https://pubmed.ncbi.nlm.nih.gov/27495901/ Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species]
	* 2015 Nov 1 [https://pubmed.ncbi.nlm.nih.gov/26318523/ Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4613501/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4613501/pdf/bj4710403.pdf PDF~~]		* 2015 Nov 1 [https://pubmed.ncbi.nlm.nih.gov/26318523/ Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus]
	* 2015 Apr 15 [https://pubmed.ncbi.nlm.nih.gov/25780044/ Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4390499/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4390499/pdf/nihms662872.pdf PDF~~]		* 2015 Apr 15 [https://pubmed.ncbi.nlm.nih.gov/25780044/ Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo]
	* 2014 Dec [https://pubmed.ncbi.nlm.nih.gov/25225247/ Fasciola hepatica fatty acid binding protein induces the alternative activation of human macrophages~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4249263/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4249263/pdf/zii5005.pdf PDF~~]		* 2014 Dec [https://pubmed.ncbi.nlm.nih.gov/25225247/ Fasciola hepatica fatty acid binding protein induces the alternative activation of human macrophages]
	* 2014 Apr [https://pubmed.ncbi.nlm.nih.gov/23179061/ ¹H, ¹³C and ¹⁵N chemical shift assignments of Na-FAR-1, a helix-rich fatty acid and retinol binding protein of the parasitic nematode Necator americanus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3955486/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3955486/pdf/12104_2012_Article_9444.pdf PDF~~]		* 2014 Apr [https://pubmed.ncbi.nlm.nih.gov/23179061/ ¹H, ¹³C and ¹⁵N chemical shift assignments of Na-FAR-1, a helix-rich fatty acid and retinol binding protein of the parasitic nematode Necator americanus]
	* 2014 Mar 20 [https://sedici.unlp.edu.ar/handle/10915/34308 Estudio biofísico y estructural de Na-FAR-1, miembro de una nueva familia de proteínas de nematodos que unen ácidos grasos y retinol] (Thesis) (Spanish)		* 2014 Mar 20 [https://sedici.unlp.edu.ar/handle/10915/34308 Estudio biofísico y estructural de Na-FAR-1, miembro de una nueva familia de proteínas de nematodos que unen ácidos grasos y retinol] (Thesis) (Spanish)
	* 2012 Jul 1 [https://pubmed.ncbi.nlm.nih.gov/22750878/ Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3388935/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3388935/pdf/f-68-00835.pdf PDF~~]		* 2012 Jul 1 [https://pubmed.ncbi.nlm.nih.gov/22750878/ Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus]
	* 2009 Dec 18 [https://pubmed.ncbi.nlm.nih.gov/19828452/ Fatty acid- and retinoid-binding proteins have distinct binding pockets for the two types of cargo~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC2791011/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC2791011/pdf/zbc35818.pdf PDF~~]		* 2009 Dec 18 [https://pubmed.ncbi.nlm.nih.gov/19828452/ Fatty acid- and retinoid-binding proteins have distinct binding pockets for the two types of cargo]
	* 2009 Dec [https://pubmed.ncbi.nlm.nih.gov/19591834/ Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC2760681/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC2760681/pdf/nihms130963.pdf PDF~~]		* 2009 Dec [https://pubmed.ncbi.nlm.nih.gov/19591834/ Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum]
	* 2009 Nov [https://pubmed.ncbi.nlm.nih.gov/19615410/ The complexity of the secreted NPA and FAR lipid-binding protein families of Haemonchus contortus revealed by an iterative proteomics-bioinformatics approach]		* 2009 Nov [https://pubmed.ncbi.nlm.nih.gov/19615410/ The complexity of the secreted NPA and FAR lipid-binding protein families of Haemonchus contortus revealed by an iterative proteomics-bioinformatics approach]
	* 2009 Sep [https://pubmed.ncbi.nlm.nih.gov/22736819/ Identification of a secreted fatty acid and retinol-binding protein (Hp-FAR-1) from Heligmosomoides polygyrus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3380493/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3380493/pdf/228.pdf PDF~~]		* 2009 Sep [https://pubmed.ncbi.nlm.nih.gov/22736819/ Identification of a secreted fatty acid and retinol-binding protein (Hp-FAR-1) from Heligmosomoides polygyrus]
	* 2009 May [https://www.proquest.com/openview/84468fd17f8a12698637899f7624a70f/1?pq-origsite=gscholar&cbl=18750 The role of fatty acid binding proteins in the pathobiology of the hookworm Ancylostoma ceylanicum] (Thesis)		* 2009 May [https://www.proquest.com/openview/84468fd17f8a12698637899f7624a70f/1?pq-origsite=gscholar&cbl=18750 The role of fatty acid binding proteins in the pathobiology of the hookworm Ancylostoma ceylanicum] (Thesis)