Helminthic Therapy wiki - Recent changes [en]

Helminthic therapy research

Jlm — Fri, 03 Apr 2026 13:49:39 GMT

2021

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	* 2021 Dec 30 [https://pubmed.ncbi.nlm.nih.gov/34969052/ Schistosome immunomodulators] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8718004/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8718004/pdf/ppat.1010064.pdf PDF]		* 2021 Dec 30 [https://pubmed.ncbi.nlm.nih.gov/34969052/ Schistosome immunomodulators] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8718004/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8718004/pdf/ppat.1010064.pdf PDF]

			* 2021 Dec 22 [https://pubmed.ncbi.nlm.nih.gov/34937173/ Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8694124/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8694124/pdf/spectrum.01910-21.pdf PDF]

	* 2021 Dec 21 [https://pubmed.ncbi.nlm.nih.gov/34933444/ Helminth-Induced Human Gastrointestinal Dysbiosis: a Systematic Review and Meta-Analysis Reveals Insights into Altered Taxon Diversity and Microbial Gradient Collapse] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8689561/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8689561/pdf/mbio.02890-21.pdf PDF]		* 2021 Dec 21 [https://pubmed.ncbi.nlm.nih.gov/34933444/ Helminth-Induced Human Gastrointestinal Dysbiosis: a Systematic Review and Meta-Analysis Reveals Insights into Altered Taxon Diversity and Microbial Gradient Collapse] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8689561/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8689561/pdf/mbio.02890-21.pdf PDF]
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	* 2021 Dec 6 [https://evmedreview.com/evolutionary-medicine-helps-explain-pandemic-dynamics-predictions-regarding-clinical-impact-of-covid-19-borne-out/ Evolutionary medicine helps explain pandemic dynamics: Predictions regarding clinical impact of COVID-19 borne out]		* 2021 Dec 6 [https://evmedreview.com/evolutionary-medicine-helps-explain-pandemic-dynamics-predictions-regarding-clinical-impact-of-covid-19-borne-out/ Evolutionary medicine helps explain pandemic dynamics: Predictions regarding clinical impact of COVID-19 borne out]

	* 2021 Dec 22 [https://pubmed.ncbi.nlm.nih.gov/~~34937173~~/ ~~Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti~~-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8694124/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8694124/pdf/spectrum.01910-21.pdf PDF]		* 2021 Dec [https://pubmed.ncbi.nlm.nih.gov/34774540/ The yin and yang of human soil-transmitted helminth infections]

	* 2021 Dec [https://pubmed.ncbi.nlm.nih.gov/34467547/ Helminth infections and cardiovascular diseases: A role for the microbiota and Mϕs?] -- [https://academic.oup.com/jleukbio/article/110/6/1269/6884696 Full text]		* 2021 Dec [https://pubmed.ncbi.nlm.nih.gov/34467547/ Helminth infections and cardiovascular diseases: A role for the microbiota and Mϕs?] -- [https://academic.oup.com/jleukbio/article/110/6/1269/6884696 Full text]

Helminthic therapy and infectious diseases

Jlm — Fri, 03 Apr 2026 13:47:02 GMT

General reviews and studies

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	* 2019 Jun 18 [https://pubmed.ncbi.nlm.nih.gov/31211774/ The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis]		* 2019 Jun 18 [https://pubmed.ncbi.nlm.nih.gov/31211774/ The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis]
	* 2019 Jun 15 [https://pubmed.ncbi.nlm.nih.gov/31200765/ Infection against infection: parasite antagonism against parasites, viruses and bacteria]		* 2019 Jun 15 [https://pubmed.ncbi.nlm.nih.gov/31200765/ Infection against infection: parasite antagonism against parasites, viruses and bacteria]
			* 2019 Jun 12 [https://tirumalaikamala.wordpress.com/2019/06/12/does-a-light-hookworm-infection-impact-ones-ability-to-fight-viral-or-bacterial-infections/ Does a light hookworm infection impact one’s ability to fight viral or bacterial infections?]
	* 2019 May 7 [https://pubmed.ncbi.nlm.nih.gov/31064387/ Associations between soil-transmitted helminthiasis and viral, bacterial, and protozoal enteroinfections: a cross-sectional study in rural Laos] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6505259/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC6505259/pdf/13071_2019_Article_3471.pdf PDF]		* 2019 May 7 [https://pubmed.ncbi.nlm.nih.gov/31064387/ Associations between soil-transmitted helminthiasis and viral, bacterial, and protozoal enteroinfections: a cross-sectional study in rural Laos] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6505259/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC6505259/pdf/13071_2019_Article_3471.pdf PDF]
	* 2018 Nov 8 [https://pubmed.ncbi.nlm.nih.gov/30467504/ The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6237250/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC6237250/pdf/fimmu-09-02579.pdf PDF]		* 2018 Nov 8 [https://pubmed.ncbi.nlm.nih.gov/30467504/ The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC6237250/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC6237250/pdf/fimmu-09-02579.pdf PDF]

Mechanisms underlying helminth colonization

Jlm — Fri, 03 Apr 2026 13:40:14 GMT

CD4+ Th2 responses

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	* 2014 Jan 30 [https://pubmed.ncbi.nlm.nih.gov/24498448/ Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ]		* 2014 Jan 30 [https://pubmed.ncbi.nlm.nih.gov/24498448/ Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ]

			* 2014 [https://link.springer.com/chapter/10.1007/978-1-4939-1489-0_1 The Role of Antibody in Parasitic Helminth Infections] (Book chaper of "How Helminths Alter Immunity to Infection") ([https://books.google.fr/books?hl=fr&lr=&id=vwKcBAAAQBAJ&oi=fnd&pg=PA1&&ots=WfhivHO4es&sig=Eujw-ljbwCiMPjkWtxW41yuY_Zw#v=onepage&q&f=false Google book])

	* 2013 Mar [https://pubmed.ncbi.nlm.nih.gov/23516361/ Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection]		* 2013 Mar [https://pubmed.ncbi.nlm.nih.gov/23516361/ Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection]
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	* 2013 Jan 1 [https://pubmed.ncbi.nlm.nih.gov/23277021/ Cell apoptosis induced by hookworm antigens: a strategy of immunomodulation]		* 2013 Jan 1 [https://pubmed.ncbi.nlm.nih.gov/23277021/ Cell apoptosis induced by hookworm antigens: a strategy of immunomodulation]
	* 2012 Dec [https://pubmed.ncbi.nlm.nih.gov/23006854/ Hookworm virulence factors: making the most of the host]		* 2012 Dec [https://pubmed.ncbi.nlm.nih.gov/23006854/ Hookworm virulence factors: making the most of the host]
			* 2012 Aug [https://onlinelibrary.wiley.com/doi/10.1002/9781118393321.ch13 Nematoda: Hookworms] (Book chapter of Immunity to Parasitic Infection)
	* 2012 Jul [https://pubmed.ncbi.nlm.nih.gov/22633322/ Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths]		* 2012 Jul [https://pubmed.ncbi.nlm.nih.gov/22633322/ Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths]
	* 2012 [http://eprints.nottingham.ac.uk/12411/ Asthma and allergic disease: their relation with Necator americanus and other helminth infections] Johanna Feary, PhD Thesis -- [http://eprints.nottingham.ac.uk/12411/1/JRF_Thesis_appendix_A_removed.pdf PDF] (NA)		* 2012 [http://eprints.nottingham.ac.uk/12411/ Asthma and allergic disease: their relation with Necator americanus and other helminth infections] Johanna Feary, PhD Thesis -- [http://eprints.nottingham.ac.uk/12411/1/JRF_Thesis_appendix_A_removed.pdf PDF] (NA)

Helminthic therapy and infectious diseases

Jlm — Fri, 03 Apr 2026 13:29:00 GMT

Helminths and HIV

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	* 2025 Dec 24 [https://pubmed.ncbi.nlm.nih.gov/41437864/ Total IgE levels in HIV-negative and HIV-positive individuals infected with parasites in rural settings of Gabon]		* 2025 Dec 24 [https://pubmed.ncbi.nlm.nih.gov/41437864/ Total IgE levels in HIV-negative and HIV-positive individuals infected with parasites in rural settings of Gabon]

			* 2025 Oct 23 [https://pubmed.ncbi.nlm.nih.gov/41130223/ Impact of Anthelmintic Therapy for Invasive Helminth Infection on Microbial Translocation, Inflammation, and Immune Response among Ugandans Living with HIV: A Randomized Proof of Concept Study]

	* 2025 Sep 8 [https://aacrjournals.org/cebp/article/34/9_Supplement/C035/764799 Gut virome remodeling in HIV–helminth co-infection reflects colorectal cancer–associated signatures in a South African cohort] also [https://www.scielo.org.za/scielo.php?pid=S0038-23612025000300021&script=sci_arttext&tlng=en Virome restructuring in HIV-helminth co-infection reveals potential biomarkers for colorectal cancer in a South African cohort]		* 2025 Sep 8 [https://aacrjournals.org/cebp/article/34/9_Supplement/C035/764799 Gut virome remodeling in HIV–helminth co-infection reflects colorectal cancer–associated signatures in a South African cohort] also [https://www.scielo.org.za/scielo.php?pid=S0038-23612025000300021&script=sci_arttext&tlng=en Virome restructuring in HIV-helminth co-infection reveals potential biomarkers for colorectal cancer in a South African cohort]

Helminthic therapy and psoriasis

Jlm — Fri, 03 Apr 2026 13:26:37 GMT

The scientific evidence

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	\|og:image=[[File:wiki.png]]}}		\|og:image=[[File:wiki.png]]}}
	[https://en.wikipedia.org/wiki/Psoriasis Psoriasis] is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin.		[https://en.wikipedia.org/wiki/Psoriasis Psoriasis] is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin.

			__TOC__

	== The anecdotal evidence ==		== The anecdotal evidence ==
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	* 2019 Sep [https://www.jidonline.org/article/S0022-202X(19)32281-X/fulltext Immunomodulation of skin inflammation by P28GST, a helminth parasite-derived protein, in a murine model of psoriasis]		* 2019 Sep [https://www.jidonline.org/article/S0022-202X(19)32281-X/fulltext Immunomodulation of skin inflammation by P28GST, a helminth parasite-derived protein, in a murine model of psoriasis]

	* 2016 Oct 15 [https://~~www~~.ncbi.nlm.nih.gov/~~pubmed~~/~~27743501~~ Mucosal and systemic immune modulation by Trichuris trichiura in a self-infected individual] -- [[media:Mucosal_and_systemic_immune_modulation_by_Trichuris_trichiura_in_a_self-infected_individual.pdf \| PDF]] (TTO)		* 2016 Oct 15 [https://pubmed.ncbi.nlm.nih.gov/27743501/ Mucosal and systemic immune modulation by Trichuris trichiura in a self-infected individual] -- [[media:Mucosal_and_systemic_immune_modulation_by_Trichuris_trichiura_in_a_self-infected_individual.pdf \| PDF]] (TTO)

	* 2006 Jun [~~http~~://~~www~~.ncbi.nlm.nih.gov/~~pubmed~~/~~16689863~~ Prevention of psoriasis-like lesions development in fsn/fsn mice by helminth glycans]		* 2006 Jun [https://pubmed.ncbi.nlm.nih.gov/16689863/ Prevention of psoriasis-like lesions development in fsn/fsn mice by helminth glycans]

	See also		See also

Mechanisms underlying helminth colonization

Jlm — Fri, 03 Apr 2026 12:30:26 GMT

Hookworm Anti-inflammatory protein (AIP) alias Tissue inhibitor of metalloprotease (TIMP)

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	* 2026 Feb [https://tjnpr.org/index.php/home/article/view/8092 Effects of Tissue Inhibitor Metalloproteinase-1 on Allergic Responses in Ovalbumin-induced Allergic Rhinitis Mice Model]		* 2026 Feb [https://tjnpr.org/index.php/home/article/view/8092 Effects of Tissue Inhibitor Metalloproteinase-1 on Allergic Responses in Ovalbumin-induced Allergic Rhinitis Mice Model]
	* 2025 Mar 12 [https://www.wirm.ch/wp-content/uploads/2025/03/FinalProgram2025oAbstracts.pdf Hookworms shape tolerogenic dendritic cell function via metabolic reprogramming] (Conference)		* 2025 Mar 12 [https://www.wirm.ch/wp-content/uploads/2025/03/FinalProgram2025oAbstracts.pdf Hookworms shape tolerogenic dendritic cell function via metabolic reprogramming] (Conference)
	* 2025 [https://memorias.ioc.fiocruz.br/article/11098/0123-therapeutic-potential-of-hookworm-proteins-in-promoting-regulatory-immune-responses-to-modulate-trypanosoma-cruzi-induced-liver-inflammation-and-oxidative-stress Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress] -- [https://memorias.ioc.fiocruz.br/article/14220?task=artigo.download PDF]
	* 2023 Oct 12 [https://pubmed.ncbi.nlm.nih.gov/38239430/ Immunomodulatory proteins from hookworms reduce cardiac inflammation and modulate regulatory responses in a mouse model of chronic Trypanosoma cruzi infection] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC10795693/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC10795693/pdf/fpara-02-1244604.pdf PDF]		* 2023 Oct 12 [https://pubmed.ncbi.nlm.nih.gov/38239430/ Immunomodulatory proteins from hookworms reduce cardiac inflammation and modulate regulatory responses in a mouse model of chronic Trypanosoma cruzi infection] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC10795693/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC10795693/pdf/fpara-02-1244604.pdf PDF]
	* 2022 Jan 15 [https://pubmed.ncbi.nlm.nih.gov/35031905/ Na-AIP-1 secreted by human hookworms suppresses collagen-induced arthritis]		* 2022 Jan 15 [https://pubmed.ncbi.nlm.nih.gov/35031905/ Na-AIP-1 secreted by human hookworms suppresses collagen-induced arthritis]

Helminthic therapy research

Jlm — Fri, 03 Apr 2026 12:30:11 GMT

2025: duplicate

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	* 2025 [https://radar.ibiss.bg.ac.rs/bitstream/handle/123456789/7709/bitstream_20907.pdf?sequence=1 Patients with Trichinella spiralis infection display unmodified antigen-specific immune response to SARS-CoV-2]		* 2025 [https://radar.ibiss.bg.ac.rs/bitstream/handle/123456789/7709/bitstream_20907.pdf?sequence=1 Patients with Trichinella spiralis infection display unmodified antigen-specific immune response to SARS-CoV-2]

	* 2025 [https://memorias.ioc.fiocruz.br/article/11098/0123-therapeutic-potential-of-hookworm-proteins-in-promoting-regulatory-immune-responses-to-modulate-trypanosoma-cruzi-induced-liver-inflammation-and-oxidative-stress Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress] -- [https://memorias.ioc.fiocruz.br/article/14220?task=artigo.download PDF]

	* 2025 [https://tcu.elsevierpure.com/en/publications/schistosoma-mansoni-soluble-egg-antigen-and-its-key-proteins-diff/ Schistosoma mansoni soluble egg antigen and its key proteins differentially affect dextran sodium sulfate-induced inflammatory bowel disease]		* 2025 [https://tcu.elsevierpure.com/en/publications/schistosoma-mansoni-soluble-egg-antigen-and-its-key-proteins-diff/ Schistosoma mansoni soluble egg antigen and its key proteins differentially affect dextran sodium sulfate-induced inflammatory bowel disease]

Helminthic therapy and infectious diseases

Jlm — Fri, 03 Apr 2026 12:29:34 GMT

Helminths and Trypanosoma cruzi (Chagas)

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	=== Helminths and Trypanosoma cruzi (Chagas) ===		=== Helminths and Trypanosoma cruzi (Chagas) ===

	* ~~2025~~ [https://~~memorias~~.~~ioc~~.~~fiocruz~~.~~br/article~~/~~11098~~/~~0123-therapeutic-potential-of-hookworm-proteins-in-promoting-regulatory-immune-responses-to-modulate-trypanosoma-cruzi-induced-liver-inflammation-and-oxidative-stress~~ Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress~~] -- [https://memorias.ioc.fiocruz.br/article/14220?task=artigo.download PDF~~]		* 2026 Feb 13 [https://pubmed.ncbi.nlm.nih.gov/41711766/ Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress]
	* 2024 Aug 12 [https://pubmed.ncbi.nlm.nih.gov/39135121/ Humans seropositive for Trypanosoma cruzi co-infected with intestinal helminths have higher infectiousness, parasitaemia and Th2-type response in the Argentine Chaco] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11320973/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11320973/pdf/13071_2024_Article_6401.pdf PDF]		* 2024 Aug 12 [https://pubmed.ncbi.nlm.nih.gov/39135121/ Humans seropositive for Trypanosoma cruzi co-infected with intestinal helminths have higher infectiousness, parasitaemia and Th2-type response in the Argentine Chaco] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11320973/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11320973/pdf/13071_2024_Article_6401.pdf PDF]
	* 2024 Feb 15 [https://pubmed.ncbi.nlm.nih.gov/38211479/ Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy]		* 2024 Feb 15 [https://pubmed.ncbi.nlm.nih.gov/38211479/ Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy]

Helminthic therapy research

Jlm — Fri, 03 Apr 2026 12:28:04 GMT

2026

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	* 2026 Feb 20 [https://pubmed.ncbi.nlm.nih.gov/41720781/ Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress]		* 2026 Feb 20 [https://pubmed.ncbi.nlm.nih.gov/41720781/ Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress]
	* 2026 Feb 18 [https://pubmed.ncbi.nlm.nih.gov/41705598/ Applications of epidemiologic transition theory to modern infectious disease medicine and epidemiology]		* 2026 Feb 18 [https://pubmed.ncbi.nlm.nih.gov/41705598/ Applications of epidemiologic transition theory to modern infectious disease medicine and epidemiology]
			* 2026 Feb 13 [https://pubmed.ncbi.nlm.nih.gov/41711766/ Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress]
	* 2026 Feb 17 [https://resvinet.org/wp-content/uploads/2026/02/RSVVW26-Abstract-Booklet.pdf Maternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity via Indole-3-Propionic Acid] (Conference) (Media coverage Medscape 2026 Mar 23 [https://www.medscape.com/viewarticle/parasitic-worms-provide-insights-rsv-prevention-2026a10008ob?form=fpf Parasitic Worms Provide Insights on RSV Prevention])		* 2026 Feb 17 [https://resvinet.org/wp-content/uploads/2026/02/RSVVW26-Abstract-Booklet.pdf Maternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity via Indole-3-Propionic Acid] (Conference) (Media coverage Medscape 2026 Mar 23 [https://www.medscape.com/viewarticle/parasitic-worms-provide-insights-rsv-prevention-2026a10008ob?form=fpf Parasitic Worms Provide Insights on RSV Prevention])
	* 2026 Feb 12 [https://www.researchsquare.com/article/rs-8780633/v1 Type-2-immune history imprints local training in nerve-airway associated interstitial macrophages (NAMs) for disease tolerance during respiratory viral infection] (Preprint)		* 2026 Feb 12 [https://www.researchsquare.com/article/rs-8780633/v1 Type-2-immune history imprints local training in nerve-airway associated interstitial macrophages (NAMs) for disease tolerance during respiratory viral infection] (Preprint)

Mechanisms underlying helminth colonization

Jlm — Fri, 03 Apr 2026 12:27:42 GMT

Hookworm Anti-inflammatory protein (AIP) alias Tissue inhibitor of metalloprotease (TIMP)

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	===Hookworm Anti-inflammatory protein (AIP) alias Tissue inhibitor of metalloprotease (TIMP)===		===Hookworm Anti-inflammatory protein (AIP) alias Tissue inhibitor of metalloprotease (TIMP)===

			* 2026 Feb 13 [https://pubmed.ncbi.nlm.nih.gov/41711766/ Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress]
	* 2026 Feb [https://tjnpr.org/index.php/home/article/view/8092 Effects of Tissue Inhibitor Metalloproteinase-1 on Allergic Responses in Ovalbumin-induced Allergic Rhinitis Mice Model]		* 2026 Feb [https://tjnpr.org/index.php/home/article/view/8092 Effects of Tissue Inhibitor Metalloproteinase-1 on Allergic Responses in Ovalbumin-induced Allergic Rhinitis Mice Model]
	* 2025 Mar 12 [https://www.wirm.ch/wp-content/uploads/2025/03/FinalProgram2025oAbstracts.pdf Hookworms shape tolerogenic dendritic cell function via metabolic reprogramming] (Conference)		* 2025 Mar 12 [https://www.wirm.ch/wp-content/uploads/2025/03/FinalProgram2025oAbstracts.pdf Hookworms shape tolerogenic dendritic cell function via metabolic reprogramming] (Conference)

Self-treating with NA

Jlm — Fri, 03 Apr 2026 12:25:56 GMT

Checking whether inoculation was successful

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	* 2026 Mar 26 [https://www.mdpi.com/2036-7449/18/2/27 Matrix-Dependent Sensitivity of Two Pan-Trematode PCR Assays for Detecting Schistosoma spp. in Clinical Human Samples]		* 2026 Mar 26 [https://www.mdpi.com/2036-7449/18/2/27 Matrix-Dependent Sensitivity of Two Pan-Trematode PCR Assays for Detecting Schistosoma spp. in Clinical Human Samples]
			* 2026 Feb 26 [https://pubmed.ncbi.nlm.nih.gov/41759907/ Hooksnip: a browser tool for designing allele-specific PCR primers in hookworm]
	* 2025 Dec 16 [https://mid.journals.ekb.eg/article_474186.html From Kato-Katz to PCR: Evaluating the evolution of diagnostic techniques for soil-transmitted helminths]		* 2025 Dec 16 [https://mid.journals.ekb.eg/article_474186.html From Kato-Katz to PCR: Evaluating the evolution of diagnostic techniques for soil-transmitted helminths]
	* 2025 Nov 11 [https://pubmed.ncbi.nlm.nih.gov/41218066/ Performance evaluation of the diaxxoPCR system for rapid and user-friendly stool-based diagnosis of trichuriasis, ascariasis and strongyloidiasis in Mozambique]		* 2025 Nov 11 [https://pubmed.ncbi.nlm.nih.gov/41218066/ Performance evaluation of the diaxxoPCR system for rapid and user-friendly stool-based diagnosis of trichuriasis, ascariasis and strongyloidiasis in Mozambique]

Helminthic therapy research

Jlm — Fri, 03 Apr 2026 12:21:22 GMT

2012

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	* 2012 Aug 13 [https://pubmed.ncbi.nlm.nih.gov/22934153/ The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial]		* 2012 Aug 13 [https://pubmed.ncbi.nlm.nih.gov/22934153/ The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial]
	* 2012 Aug [https://pubmed.ncbi.nlm.nih.gov/22223533/ Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4123417/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4123417/pdf/nihms340401.pdf PDF]		* 2012 Aug [https://pubmed.ncbi.nlm.nih.gov/22223533/ Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4123417/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4123417/pdf/nihms340401.pdf PDF]
			* 2012 Aug [https://academic.oup.com/jimmunol/article-abstract/189/3/1101/7994782?redirectedFrom=fulltext Costs and Benefits of Immunity to Worm Infection]
	* 2012 Jul 15 [https://pubmed.ncbi.nlm.nih.gov/24533279/ Worming our way closer to the clinic] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3862412/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3862412/pdf/main.pdf PDF]		* 2012 Jul 15 [https://pubmed.ncbi.nlm.nih.gov/24533279/ Worming our way closer to the clinic] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3862412/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3862412/pdf/main.pdf PDF]
	* 2012 Jul [https://pubmed.ncbi.nlm.nih.gov/22742834 Trichuris suis ova: testing a helminth-based therapy as an extension of the hygiene hypothesis] -- [https://web.archive.org/web/20210921041516/https://parasitology.cvm.ncsu.edu/vmp930/supplement/trichuris_treatment_allergies.pdf PDF] (TSO)		* 2012 Jul [https://pubmed.ncbi.nlm.nih.gov/22742834 Trichuris suis ova: testing a helminth-based therapy as an extension of the hygiene hypothesis] -- [https://web.archive.org/web/20210921041516/https://parasitology.cvm.ncsu.edu/vmp930/supplement/trichuris_treatment_allergies.pdf PDF] (TSO)

Helminthic therapy in the media

Jlm — Fri, 03 Apr 2026 11:53:53 GMT

Articles

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	'''2011'''		'''2011'''

			* 2011 Aug 6 [https://www.doi.org/10.1016/S0262-4079(11)61868-X One sugar or two with your parasites?] - Ferris Jabr, The New Scientist
			* 2011 Aug 6 [https://www.doi.org/10.1016/s0262-4079(11)61858-7 Let them eat worms] - Editorial, The New Scientist
	* 2011 Jul [http://www.foodsmatter.com/natural_medicine_comp_therapies/helminthic_therapy/articles/headache_migraine.html Helminths Give Chronic Headaches the Old Heave-ho] - John Scott, Foods Matter		* 2011 Jul [http://www.foodsmatter.com/natural_medicine_comp_therapies/helminthic_therapy/articles/headache_migraine.html Helminths Give Chronic Headaches the Old Heave-ho] - John Scott, Foods Matter
	* 2011 Jun 28 [http://www.wsj.com/articles/SB10001424052702304314404576413303666083390 Parasitic Worms May Offer Hope on MS] - Sten Stovall, Wall Street Journal (multiple sclerosis)		* 2011 Jun 28 [http://www.wsj.com/articles/SB10001424052702304314404576413303666083390 Parasitic Worms May Offer Hope on MS] - Sten Stovall, Wall Street Journal (multiple sclerosis)

Helminthic therapy in the media

John — Fri, 03 Apr 2026 00:27:00 GMT

Articles

← Older revision		Revision as of 00:27, 3 April 2026
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	'''2011'''		'''2011'''

	* 2011 Aug 6 [https://sci-hub.fr/10.1016/S0262-4079(11)61868-X One sugar or two with your parasites?] - Ferris Jabr, The New Scientist
	* 2011 Aug 6 [https://sci-hub.fr/10.1016/s0262-4079(11)61858-7 Let them eat worms] - Editorial, The New Scientist
	* 2011 Jul [http://www.foodsmatter.com/natural_medicine_comp_therapies/helminthic_therapy/articles/headache_migraine.html Helminths Give Chronic Headaches the Old Heave-ho] - John Scott, Foods Matter		* 2011 Jul [http://www.foodsmatter.com/natural_medicine_comp_therapies/helminthic_therapy/articles/headache_migraine.html Helminths Give Chronic Headaches the Old Heave-ho] - John Scott, Foods Matter
	* 2011 Jun 28 [http://www.wsj.com/articles/SB10001424052702304314404576413303666083390 Parasitic Worms May Offer Hope on MS] - Sten Stovall, Wall Street Journal (multiple sclerosis)		* 2011 Jun 28 [http://www.wsj.com/articles/SB10001424052702304314404576413303666083390 Parasitic Worms May Offer Hope on MS] - Sten Stovall, Wall Street Journal (multiple sclerosis)

Helminth provider reviews

John — Fri, 03 Apr 2026 00:09:39 GMT

Au NAturel

← Older revision		Revision as of 00:09, 3 April 2026
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	<blockquote>		<blockquote>

	<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Fantastic provider'''<br>MJ, 3 Apr 2026<br>This is a fantastic provider. I have gladly used several times for two years.		<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Fantastic provider'''<br>Myles, 3 Apr 2026<br>This is a fantastic provider. I have gladly used several times for two years.

	<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Solid service'''<br>Tom, 19 Feb 2025<br>I have used Au NAturel for many years - always outstanding service and response. I've never had an issue with Max.		<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Solid service'''<br>Tom, 19 Feb 2025<br>I have used Au NAturel for many years - always outstanding service and response. I've never had an issue with Max.

Helminth providers

John — Thu, 02 Apr 2026 23:56:01 GMT

Au NAturel ★★★★★

← Older revision		Revision as of 23:56, 2 April 2026
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	===<span style="font-size:18px;">'''Au NAturel'''</span> <span style="color:#e68a00;font-size:20px;">★★★★★</span>===		===<span style="font-size:18px;">'''Au NAturel'''</span> <span style="color:#e68a00;font-size:20px;">★★★★★</span>===
	5 out of 5 stars. [[Helminth provider reviews#Au NAturel \| '''30 customer reviews''']].<br>		5 out of 5 stars. [[Helminth provider reviews#Au NAturel \| '''31 customer reviews''']].<br>
	Founded: 2019.<br>		Founded: 2019.<br>
	Organism supplied: [[Selecting a therapeutic helminth#NA (Necator americanus) \| NA]].<br>		Organism supplied: [[Selecting a therapeutic helminth#NA (Necator americanus) \| NA]].<br>

Helminth provider reviews

John — Thu, 02 Apr 2026 23:54:58 GMT

Au NAturel

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	== Au NAturel ==		== Au NAturel ==
	<blockquote>		<blockquote>

			<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Fantastic provider'''<br>MJ, 3 Apr 2026<br>This is a fantastic provider. I have gladly used several times for two years.

	<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Solid service'''<br>Tom, 19 Feb 2025<br>I have used Au NAturel for many years - always outstanding service and response. I've never had an issue with Max.		<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Solid service'''<br>Tom, 19 Feb 2025<br>I have used Au NAturel for many years - always outstanding service and response. I've never had an issue with Max.

	<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Great provider of NA!'''<br>Jonathan, 8 Dec 2024<br>He's been great, super communicative and helpful, fast reliable delivery, great results.		<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''Great provider of NA!'''<br>Jonathan, 8 Dec 2024<br>He's been great, super communicative and helpful, fast reliable delivery, great results.
			{{Expando\|More reviews...}}
			<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''100% trustworthy'''<br>Miro Zaleta, 27 Apr 2024<br>I made a mistake when storing my larvae so none survived. Max immediately sent the full sum of money back upon learning about it - no questions asked - and offered to send me a new dose. I offered to pay 30% more for the new dose, as I believe it was my mistake, but he declined the offer and asked just for the agreed price. That immediately increased the already high trust I had towards Max, built over the last three years that I have been dealing with him. Whenever we had a problem - like when the delivery company sent the parcel to the other side of the world by mistake so it took two months to arrive - I had a sense from Max's responses that he has my wellbeing in mind. Thank you Max!

	<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''100% trustworthy'''<br>Miro Zaleta, 27 Apr 2024<br>I made a mistake when storing my larvae so none survived. Max immediately sent the full sum of money back upon learning about it - no questions asked - and offered to send me a new dose. I offered to pay 30% more for the new dose, as I believe it was my mistake, but he declined the offer and asked just for the agreed price. That immediately increased the already high trust I had towards Max, built over the last three years that I have been dealing with him. Whenever we had a problem - like when the delivery company sent the parcel to the other side of the world by mistake so it took two months to arrive - I had a sense from Max's responses that he has my wellbeing in mind. Thank you Max!
	~~{{Expando\|More reviews...}}~~
	<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''So pleased with my experience'''<br>Mitzy, 17 Apr 2024<br>About one year ago, after spending countless hours researching, I finally decided to reach out to seek helminth therapy for my husband with debilitating Psoriatic Arthiritis. He was on Cosyntex, a biologic, and Celbrex, with high doses of NSAIDs. His bowels and body were really suffering. We chose this provider, AU NAturel, because he was straightforward. His response time was impeccable. Taking a leap of faith, we started this journey not knowing what would happen. I have been so pleased at my husband's ability to get out of bed. He is becoming active again. He is getting his life back. I am so grateful for Max. I feel like there is a genuine effort to help people, and it has made a huge difference in our lives, especially with a another baby on the way. Cheers to 1 year working together!		<span style="color:#e68a00;font-size:20px;">★★★★★</span> '''So pleased with my experience'''<br>Mitzy, 17 Apr 2024<br>About one year ago, after spending countless hours researching, I finally decided to reach out to seek helminth therapy for my husband with debilitating Psoriatic Arthiritis. He was on Cosyntex, a biologic, and Celbrex, with high doses of NSAIDs. His bowels and body were really suffering. We chose this provider, AU NAturel, because he was straightforward. His response time was impeccable. Taking a leap of faith, we started this journey not knowing what would happen. I have been so pleased at my husband's ability to get out of bed. He is becoming active again. He is getting his life back. I am so grateful for Max. I feel like there is a genuine effort to help people, and it has made a huge difference in our lives, especially with a another baby on the way. Cheers to 1 year working together!

Helminthic therapy research

Jlm — Thu, 02 Apr 2026 20:52:46 GMT

2021

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	* 2022 Nov 21 [https://www.biorxiv.org/content/10.1101/2022.06.02.494558v2.full.pdf Natural strongyle infection reduces relative abundance of inflammation-inducing Prevotella in wild primates] (Preprint)		* 2022 Nov 21 [https://www.biorxiv.org/content/10.1101/2022.06.02.494558v2.full.pdf Natural strongyle infection reduces relative abundance of inflammation-inducing Prevotella in wild primates] (Preprint)

			* 2022 Nov 20 [https://www.sciencedirect.com/science/article/pii/S1201971223002527 Demystifying the gut worms] (Conference)

	* 2022 Nov 20 [https://pubmed.ncbi.nlm.nih.gov/36443262/ Schistosoma japonicum Eggs Exerts Protective Effects in an Experimental Ulcerative Colitis Model] -- [https://www.besjournal.com/en/article/doi/10.3967/bes2022.138 Full text]		* 2022 Nov 20 [https://pubmed.ncbi.nlm.nih.gov/36443262/ Schistosoma japonicum Eggs Exerts Protective Effects in an Experimental Ulcerative Colitis Model] -- [https://www.besjournal.com/en/article/doi/10.3967/bes2022.138 Full text]
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	* 2021 Oct 7 [https://pubmed.ncbi.nlm.nih.gov/34691057/ Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells]		* 2021 Oct 7 [https://pubmed.ncbi.nlm.nih.gov/34691057/ Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells]

			* 2021 Oct-Dec [https://www.sciencevision.org/issue/51/article/316 Parasites: Disease or cure?]

	* 2021 Oct [https://pubmed.ncbi.nlm.nih.gov/34274545/ Parasite-based interventions in systemic lupus erythematosus (SLE): A systematic review]		* 2021 Oct [https://pubmed.ncbi.nlm.nih.gov/34274545/ Parasite-based interventions in systemic lupus erythematosus (SLE): A systematic review]
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	* 2018 [https://ru.dgb.unam.mx/items/9689a401-2df0-4281-8008-af40bc99832a Efecto de la administración de los productos de excreción-secreción (es) y del extracto crudo (ec) de Hymenolepis nana en la diabetes experimental murina inducida por streptozotocina] (Licence, Mexico, Spanish)		* 2018 [https://ru.dgb.unam.mx/items/9689a401-2df0-4281-8008-af40bc99832a Efecto de la administración de los productos de excreción-secreción (es) y del extracto crudo (ec) de Hymenolepis nana en la diabetes experimental murina inducida por streptozotocina] (Licence, Mexico, Spanish)
	* 2018 [https://www.researchgate.net/profile/Mahdi-Fakhar/publication/327437681_Good_Bacteria_and_Worms_As_Promising_Candidates_for_Inflammatory_Bowel_Disease/links/5b8fadf6a6fdcc1ddd1022c1/Good-Bacteria-and-Worms-As-Promising-Candidates-for-Inflammatory-Bowel-Disease.pdf Good Bacteria and Worms: As Promising Candidates for Inflammatory Bowel Disease] (Persian)		* 2018 [https://www.researchgate.net/profile/Mahdi-Fakhar/publication/327437681_Good_Bacteria_and_Worms_As_Promising_Candidates_for_Inflammatory_Bowel_Disease/links/5b8fadf6a6fdcc1ddd1022c1/Good-Bacteria-and-Worms-As-Promising-Candidates-for-Inflammatory-Bowel-Disease.pdf Good Bacteria and Worms: As Promising Candidates for Inflammatory Bowel Disease] (Persian)
			* 2018 [https://www.cntropmed.com/EN/abstract/abstract13488.shtml Advances on parasitic helminths in the treatment of autoimmune diseases] (Chinese)

	=== 2017 ===		=== 2017 ===

Helminthic therapy personal stories

Jlm — Thu, 02 Apr 2026 19:31:53 GMT

Crohn's disease

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	:* [[Wriggling out of total food intolerance, M.E. and Crohn’s disease \| '''Wriggling out of total food intolerance, M.E. and Crohn’s disease''']]		:* [[Wriggling out of total food intolerance, M.E. and Crohn’s disease \| '''Wriggling out of total food intolerance, M.E. and Crohn’s disease''']]
	:* [[Four family members with gut issues are all delighted with their worms \| '''Four family members with gut issues are all delighted with their worms''']]		:* [[Four family members with gut issues are all delighted with their worms \| '''Four family members with gut issues are all delighted with their worms''']]

			* Michael was diagnosed with Crohn’s disease in 1996 as a 17-year-old. Three operations and a slew of drugs relieved the symptoms, but only at the cost of unbearable side effects. After reading scores of research papers, Michael decided to try helminthic therapy. He was not overjoyed at the idea of swallowing worms, but everything he read convinced him it was worth the risk. When he was 25 he ordered a batch of pig whipworm eggs from a German company called Ovamed (it is illegal to sell or breed helminths in the US). Michael drank 2500 eggs every two weeks for three months. His symptoms began to disappear. In April 2010 he allowed 35 hookworm larvae to burrow into his skin and says that his Crohn’s disease has been in remission ever since. “As soon as you say worms people get freaked out,” Michael says. “But it’s not like you feel disgusting worms wriggling inside you. People forget that they have billions of bacteria crawling over their skin right now.” Before self-infecting, Michael’s intestines were ravaged and bleeding. When Moshe Rubin of the New York Hospital Queens examined Michael’s intestine earlier this year, he found that his “small bowel looked almost completely normal”. “It’s not a controlled trial, but the suggestion based on this observation is that helminthic therapy was helping him,” Rubin says. (Citizen scientist: hookworms changed my life, New Scientist, [https://sci-hub.fr/10.1016/S0262-4079(11)61868-X 2011 Aug 6])

	* "... it seems to have worked...my doctor is pretty optimistic about it actually." (Link expired)		* "... it seems to have worked...my doctor is pretty optimistic about it actually." (Link expired)

Helminthic therapy in the media

Jlm — Thu, 02 Apr 2026 19:16:19 GMT

Articles

← Older revision		Revision as of 19:16, 2 April 2026
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	'''2011'''		'''2011'''

	* 2011 Aug 6 [https://sci-hub.ru/10.1016/s0262-4079(11)61858-7 Let them eat worms] - Editorial, The New Scientist		* 2011 Aug 6 [https://sci-hub.fr/10.1016/S0262-4079(11)61868-X One sugar or two with your parasites?] - Ferris Jabr, The New Scientist
			* 2011 Aug 6 [https://sci-hub.fr/10.1016/s0262-4079(11)61858-7 Let them eat worms] - Editorial, The New Scientist
	* 2011 Jul [http://www.foodsmatter.com/natural_medicine_comp_therapies/helminthic_therapy/articles/headache_migraine.html Helminths Give Chronic Headaches the Old Heave-ho] - John Scott, Foods Matter		* 2011 Jul [http://www.foodsmatter.com/natural_medicine_comp_therapies/helminthic_therapy/articles/headache_migraine.html Helminths Give Chronic Headaches the Old Heave-ho] - John Scott, Foods Matter
	* 2011 Jun 28 [http://www.wsj.com/articles/SB10001424052702304314404576413303666083390 Parasitic Worms May Offer Hope on MS] - Sten Stovall, Wall Street Journal (multiple sclerosis)		* 2011 Jun 28 [http://www.wsj.com/articles/SB10001424052702304314404576413303666083390 Parasitic Worms May Offer Hope on MS] - Sten Stovall, Wall Street Journal (multiple sclerosis)

Mechanisms underlying helminth colonization

Jlm — Thu, 02 Apr 2026 19:11:07 GMT

CD4+ Th2 responses

← Older revision		Revision as of 19:11, 2 April 2026
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	* 2016 Dec 1 [https://pubmed.ncbi.nlm.nih.gov/27798167/ BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity]		* 2016 Dec 1 [https://pubmed.ncbi.nlm.nih.gov/27798167/ BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity]

			* 2016 Mar 2 [https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0000482.pub2 Immunity to Parasitic Worms]

	* 2016 Feb [https://pubmed.ncbi.nlm.nih.gov/26490658/ The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4973506/ Full text]		* 2016 Feb [https://pubmed.ncbi.nlm.nih.gov/26490658/ The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4973506/ Full text]
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	* 2026 Apr [https://pubmed.ncbi.nlm.nih.gov/41906940/ Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection]		* 2026 Apr [https://pubmed.ncbi.nlm.nih.gov/41906940/ Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection]

			* 2026 Mar 17 [https://pubmed.ncbi.nlm.nih.gov/41843614/ Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system]

	* 2026 Mar 4 [https://pubmed.ncbi.nlm.nih.gov/41781415/ The immune-modulatory potential of helminth-derived proteins in cellular models of inflammation: a systematic review with cross-study quantitative data analysis]		* 2026 Mar 4 [https://pubmed.ncbi.nlm.nih.gov/41781415/ The immune-modulatory potential of helminth-derived proteins in cellular models of inflammation: a systematic review with cross-study quantitative data analysis]
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	* 2019 Oct [https://pubmed.ncbi.nlm.nih.gov/31492623 Immune Regulation of Metabolic Homeostasis by Helminths and Their Molecules]		* 2019 Oct [https://pubmed.ncbi.nlm.nih.gov/31492623 Immune Regulation of Metabolic Homeostasis by Helminths and Their Molecules]

			* 2019 Jul 30 [https://pubmed.ncbi.nlm.nih.gov/31071474/ High throughput LC-MS/MS-based proteomic analysis of excretory-secretory products from short-term in vitro culture of Haemonchus contortus]

	* 2019 Jul 4 [https://pubmed.ncbi.nlm.nih.gov/31277509/ Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis]		* 2019 Jul 4 [https://pubmed.ncbi.nlm.nih.gov/31277509/ Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis]
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	* 2013 Aug 2 [https://ediss.sub.uni-hamburg.de/handle/ediss/5084 Strukturelle und biochemische Charakterisierung ausgewählter Proteine und Peptide des Interaktoms zyklischer Parasitosen] (Thesis, Hamburg, German)		* 2013 Aug 2 [https://ediss.sub.uni-hamburg.de/handle/ediss/5084 Strukturelle und biochemische Charakterisierung ausgewählter Proteine und Peptide des Interaktoms zyklischer Parasitosen] (Thesis, Hamburg, German)

	* 2013 Jan 31 [https://pubmed.ncbi.nlm.nih.gov/23021260/ Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4096658/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4096658/pdf/emss-59499.pdf PDF~~]		* 2013 Aug [https://pubmed.ncbi.nlm.nih.gov/23966853/ Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity]

			* 2013 Jan 31 [https://pubmed.ncbi.nlm.nih.gov/23021260/ Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40]

	* 2012 Dec 13 [https://pubmed.ncbi.nlm.nih.gov/23281827/ Helminth secretome database (HSD): a collection of helminth excretory/secretory proteins predicted from expressed sequence tags (ESTs)] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3546426/ Full text]		* 2012 Dec 13 [https://pubmed.ncbi.nlm.nih.gov/23281827/ Helminth secretome database (HSD): a collection of helminth excretory/secretory proteins predicted from expressed sequence tags (ESTs)] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3546426/ Full text]
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	* 2003 Nov [https://pubmed.ncbi.nlm.nih.gov/14579263/ Control of inflammatory diseases by pathogens: lipids and the immune system]		* 2003 Nov [https://pubmed.ncbi.nlm.nih.gov/14579263/ Control of inflammatory diseases by pathogens: lipids and the immune system]

			* 2003 Aug [https://pubmed.ncbi.nlm.nih.gov/12906874/ Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum]

	* 2001 Jul [https://pubmed.ncbi.nlm.nih.gov/11472553/ Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity]		* 2001 Jul [https://pubmed.ncbi.nlm.nih.gov/11472553/ Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity]

Helminthic therapy research

Jlm — Thu, 02 Apr 2026 18:55:44 GMT

2017

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	* 2017 [https://ru.dgb.unam.mx/items/0d888727-6a7f-43ab-9869-5cc60a1df61c Determinación de citocinas en ratones inmunizados con la calreticulina de taenia solium en un modelo de colitis]		* 2017 [https://ru.dgb.unam.mx/items/0d888727-6a7f-43ab-9869-5cc60a1df61c Determinación de citocinas en ratones inmunizados con la calreticulina de taenia solium en un modelo de colitis]
	* 2017 [https://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_wcbx201706011 Advances in Study on Helminths in Treatment of Inflammatory Bowel Disease] (Chinese)		* 2017 [https://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_wcbx201706011 Advances in Study on Helminths in Treatment of Inflammatory Bowel Disease] (Chinese)
			* 2017 [https://pubmed.ncbi.nlm.nih.gov/28432858/ Regulatory function of parasites in autoimmune disease – outcome from experimental model infection]

	=== 2016 ===		=== 2016 ===

Mechanisms underlying helminth colonization

Jlm — Thu, 02 Apr 2026 18:55:04 GMT

CD4+ Treg cells (Foxp3+)

← Older revision		Revision as of 18:55, 2 April 2026
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	* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18931678/ Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset]		* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18931678/ Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset]
	* 2007 May 16 [https://edoc.hu-berlin.de/items/e540b159-4668-4e37-b23a-3877dd413cf9 Development of regulatory T cells and induction of mucosa-specific homing] (Thesis, Humboldt Berlin)		* 2007 May 16 [https://edoc.hu-berlin.de/items/e540b159-4668-4e37-b23a-3877dd413cf9 Development of regulatory T cells and induction of mucosa-specific homing] (Thesis, Humboldt Berlin)
			* 2003 Nov 15 [https://pubmed.ncbi.nlm.nih.gov/14607897/ CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4]

	=== CD8+ Tregs ===		=== CD8+ Tregs ===

Helminthic therapy and inflammatory bowel disease (IBD)

Jlm — Thu, 02 Apr 2026 18:54:46 GMT

Not-directly-related research

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	* 2011 Jun [https://pubmed.ncbi.nlm.nih.gov/21428908/ Interleukin-25 negatively controls pathogenic responses in the gut]		* 2011 Jun [https://pubmed.ncbi.nlm.nih.gov/21428908/ Interleukin-25 negatively controls pathogenic responses in the gut]

			* 2003 Nov 15 [https://pubmed.ncbi.nlm.nih.gov/14607897/ CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4]

	* 2002 Jun [https://pubmed.ncbi.nlm.nih.gov/12094864/ Elevated serum eotaxin levels in patients with inflammatory bowel disease] -- [https://www.sciencedirect.com/science/article/abs/pii/S0002927002040431 Full text]		* 2002 Jun [https://pubmed.ncbi.nlm.nih.gov/12094864/ Elevated serum eotaxin levels in patients with inflammatory bowel disease] -- [https://www.sciencedirect.com/science/article/abs/pii/S0002927002040431 Full text]

Mechanisms underlying helminth colonization

Jlm — Thu, 02 Apr 2026 18:51:00 GMT

Studies of Necator americanus

← Older revision		Revision as of 18:51, 2 April 2026
(2 intermediate revisions by the same user not shown)
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	* 2003 Feb [https://pubmed.ncbi.nlm.nih.gov/12636356/ Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules]		* 2003 Feb [https://pubmed.ncbi.nlm.nih.gov/12636356/ Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules]
	* 2002 Sep [https://pubmed.ncbi.nlm.nih.gov/12205047/ Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity]		* 2002 Sep [https://pubmed.ncbi.nlm.nih.gov/12205047/ Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity]
			* 2002 [https://espace.library.uq.edu.au/view/UQ:105914 Hookworm aspartic proteases & their contribution to host specificity] (Thesis, Queensland)

	=== Cathepsin B-like Protease ===		=== Cathepsin B-like Protease ===
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	* 2017 Apr 8 [https://pubmed.ncbi.nlm.nih.gov/28390393 Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385058/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385058/pdf/12879_2017_Article_2366.pdf PDF]		* 2017 Apr 8 [https://pubmed.ncbi.nlm.nih.gov/28390393 Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385058/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385058/pdf/12879_2017_Article_2366.pdf PDF]
	* 2016 Oct 26 [https://pubmed.ncbi.nlm.nih.gov/27797959/ Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma]		* 2016 Oct 26 [https://pubmed.ncbi.nlm.nih.gov/27797959/ Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma]
			* 2016 Aug 12 [https://www.dovepress.com/experimental-human-hookworm-infection-therapeutic-potential-peer-reviewed-article-RIP Experimental human hookworm infection: therapeutic potential]
	* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25139017/ Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling]		* 2015 Feb 1 [https://pubmed.ncbi.nlm.nih.gov/25139017/ Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling]
	* 2014 Sep [https://pubmed.ncbi.nlm.nih.gov/25195885/ Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione]		* 2014 Sep [https://pubmed.ncbi.nlm.nih.gov/25195885/ Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione]

Helminthic therapy and cancer

Jlm — Thu, 02 Apr 2026 13:23:59 GMT

Cancer-promoting helminths

← Older revision		Revision as of 13:23, 2 April 2026
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	* 2011 Jun 28 [https://pubmed.ncbi.nlm.nih.gov/20667649/ Helminths in human carcinogenesis]		* 2011 Jun 28 [https://pubmed.ncbi.nlm.nih.gov/20667649/ Helminths in human carcinogenesis]
	* 2009 Nov [https://pubmed.ncbi.nlm.nih.gov/19825108/ Helminths and malignancy] -- [https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2009.01163.x Full text]		* 2009 Nov [https://pubmed.ncbi.nlm.nih.gov/19825108/ Helminths and malignancy] -- [https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2009.01163.x Full text]
			* 2009 [https://espace.library.uq.edu.au/view/UQ:194967 Searching the secretome of Opisthorchis viverrini for growth factor-like molecules] (Thesis, Queensland)
	* 2007 [https://pubmed.ncbi.nlm.nih.gov/18063098/ The role of helminth infections in carcinogenesis]		* 2007 [https://pubmed.ncbi.nlm.nih.gov/18063098/ The role of helminth infections in carcinogenesis]
	* 2005 Apr [https://pubmed.ncbi.nlm.nih.gov/15928434/ Association of parasitic infections and cancers]		* 2005 Apr [https://pubmed.ncbi.nlm.nih.gov/15928434/ Association of parasitic infections and cancers]

Mechanisms underlying helminth colonization

Jlm — Thu, 02 Apr 2026 13:23:24 GMT

Transforming Growth Factor-β mimic (TGM, TGF-β mimic)

← Older revision		Revision as of 13:23, 2 April 2026
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	=== Mast cells ===		=== Mast cells ===

			* 2026 Apr [https://pubmed.ncbi.nlm.nih.gov/41906940/ Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection]
	* 2026 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/41813898/ A mechanism to initiate emergency type 2 myelopoiesis] (Nature)		* 2026 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/41813898/ A mechanism to initiate emergency type 2 myelopoiesis] (Nature)
	* 2025 Nov 4 [https://www.biorxiv.org/content/10.1101/2025.11.03.686316v1.abstract Transcriptomic and proteomic analysis show minimal role for mast cell ST2 in primary Heligmosomoides polygyrus bakeri infection] -- [https://www.biorxiv.org/content/10.1101/2025.11.03.686316v1.full.pdf PDF] (Preprint)		* 2025 Nov 4 [https://www.biorxiv.org/content/10.1101/2025.11.03.686316v1.abstract Transcriptomic and proteomic analysis show minimal role for mast cell ST2 in primary Heligmosomoides polygyrus bakeri infection] -- [https://www.biorxiv.org/content/10.1101/2025.11.03.686316v1.full.pdf PDF] (Preprint)
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	=== Group 2 innate lymphoid cells (ILC2s) ===		=== Group 2 innate lymphoid cells (ILC2s) ===

			* 2026 May 4 [https://pubmed.ncbi.nlm.nih.gov/41915169/ Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity] -- [https://rupress.org/jem/article/223/5/e20250781/281713 Full text]

	* 2026 Mar 27 [https://pubmed.ncbi.nlm.nih.gov/41903550/ Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection] (Online ahead of print)		* 2026 Mar 27 [https://pubmed.ncbi.nlm.nih.gov/41903550/ Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection] (Online ahead of print)
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	* 2009 May 11 [https://pubmed.ncbi.nlm.nih.gov/19380638/ IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells]		* 2009 May 11 [https://pubmed.ncbi.nlm.nih.gov/19380638/ IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells]

			* 2009 [https://espace.library.uq.edu.au/view/UQ:205400 Regulation and Function of Jagged 1 in the Immune Response to Helminth Products] (Thesis, Queensland)

	* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18997793/ IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells]		* 2008 Dec [https://pubmed.ncbi.nlm.nih.gov/18997793/ IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells]
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	* 2013 [https://pubmed.ncbi.nlm.nih.gov/25383073/ Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/pdf/nihms563850.pdf PDF]		* 2013 [https://pubmed.ncbi.nlm.nih.gov/25383073/ Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/pdf/nihms563850.pdf PDF]
	* 2010 Aug [https://digital.library.adelaide.edu.au/items/6e30f900-3003-40e7-b068-aa4f45961357 Host-parasite interactions in primary and secondary infections with Nippostrongylus brasiliensis and Heligmosomoides bakeri] (Thesis)		* 2010 Aug [https://digital.library.adelaide.edu.au/items/6e30f900-3003-40e7-b068-aa4f45961357 Host-parasite interactions in primary and secondary infections with Nippostrongylus brasiliensis and Heligmosomoides bakeri] (Thesis)
			* 2010 [https://espace.library.uq.edu.au/view/UQ:205370 Transcriptomics of Schistosoma japonicum-induced immunopathology] (Thesis, Queensland)
	* 2009 Aug [https://pubmed.ncbi.nlm.nih.gov/19535141/ The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri] -- [https://openresearch-repository.anu.edu.au/server/api/core/bitstreams/fe2c741a-90fe-41f5-b5d4-94359eb317ea/content PDF]		* 2009 Aug [https://pubmed.ncbi.nlm.nih.gov/19535141/ The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri] -- [https://openresearch-repository.anu.edu.au/server/api/core/bitstreams/fe2c741a-90fe-41f5-b5d4-94359eb317ea/content PDF]
	* 2007 Aug [https://pubmed.ncbi.nlm.nih.gov/17650182/ Heligmosomoides polygyrus infection down-regulates eotaxin concentration and CCR3 expression on lung eosinophils in murine allergic pulmonary inflammation]		* 2007 Aug [https://pubmed.ncbi.nlm.nih.gov/17650182/ Heligmosomoides polygyrus infection down-regulates eotaxin concentration and CCR3 expression on lung eosinophils in murine allergic pulmonary inflammation]
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	See also TGF-β above		See also TGF-β above

			=== Growth factor-like molecules ===

			* 2009 [https://espace.library.uq.edu.au/view/UQ:194967 Searching the secretome of Opisthorchis viverrini for growth factor-like molecules] (Thesis, Queensland)

	=== Helminth antimicrobial peptides (AMPs) ===		=== Helminth antimicrobial peptides (AMPs) ===
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	* 2012 Feb [https://pubmed.ncbi.nlm.nih.gov/22005034/ SCP/TAPS proteins in helminths--where to from now?]		* 2012 Feb [https://pubmed.ncbi.nlm.nih.gov/22005034/ SCP/TAPS proteins in helminths--where to from now?]

			* 2009 [https://espace.library.uq.edu.au/view/UQ:194967 Searching the secretome of Opisthorchis viverrini for growth factor-like molecules] (Thesis, Queensland)

	=== Helminth defense molecules (HDMs) ===		=== Helminth defense molecules (HDMs) ===
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	=== General E/S analysis ===		=== General E/S analysis ===

			* 2026 Apr [https://pubmed.ncbi.nlm.nih.gov/41906940/ Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection]

	* 2026 Mar 4 [https://pubmed.ncbi.nlm.nih.gov/41781415/ The immune-modulatory potential of helminth-derived proteins in cellular models of inflammation: a systematic review with cross-study quantitative data analysis]		* 2026 Mar 4 [https://pubmed.ncbi.nlm.nih.gov/41781415/ The immune-modulatory potential of helminth-derived proteins in cellular models of inflammation: a systematic review with cross-study quantitative data analysis]

Helminthic therapy and infectious diseases

Jlm — Thu, 02 Apr 2026 12:58:32 GMT

Helminths and malaria

← Older revision		Revision as of 12:58, 2 April 2026
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	* 2026 Mar 31 [https://pubmed.ncbi.nlm.nih.gov/41918093/ Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria]		* 2026 Mar 31 [https://pubmed.ncbi.nlm.nih.gov/41918093/ Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria]
	:{{Quote\|indent}}STH infections were associated with decreased P. falciparum parasitemia, downregulation of inflammatory cytokines, and enhanced antibody responses, potentially resulting in milder malaria episodes, suggesting enhanced protective immunity.{{Quote\|/indent}}		:{{Quote\|indent}}STH infections were associated with decreased P. falciparum parasitemia, downregulation of inflammatory cytokines, and enhanced antibody responses, potentially resulting in milder malaria episodes, suggesting enhanced protective immunity.{{Quote\|/indent}}

			* 2026 Mar 31 [https://journals.sagepub.com/doi/10.1177/20499361261425774 Haematological responses in children under 5 years with malaria and soil-transmitted helminth coinfections in Delta State, Nigeria: a cross-sectional study]

	* 2026 Mar 18 [https://pubmed.ncbi.nlm.nih.gov/41849415/ Coinfection with malaria alters the fecundity and within-host persistence of an intestinal nematode]		* 2026 Mar 18 [https://pubmed.ncbi.nlm.nih.gov/41849415/ Coinfection with malaria alters the fecundity and within-host persistence of an intestinal nematode]

Helminthic therapy and allergy

Jlm — Thu, 02 Apr 2026 12:55:56 GMT

Helminths that promote allergies

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	=== Helminths that promote allergies ===		=== Helminths that promote allergies ===

			* 2026 Mar 31 [https://uniconflix.com/index.php/ICMA/article/view/4136 Development of allergic reactions and atopic diseases in children with helminth infections]
	* 2020 [https://pubmed.ncbi.nlm.nih.gov/31284858/ Allergen-like Molecules from Parasites]		* 2020 [https://pubmed.ncbi.nlm.nih.gov/31284858/ Allergen-like Molecules from Parasites]
	* 2018 Jan [https://pubmed.ncbi.nlm.nih.gov/29117468/ Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway]		* 2018 Jan [https://pubmed.ncbi.nlm.nih.gov/29117468/ Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway]

Helminthic therapy and infectious diseases

Jlm — Thu, 02 Apr 2026 12:50:05 GMT

Helminths and malaria

← Older revision		Revision as of 12:50, 2 April 2026
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	:{{Quote\|indent}}STH infections were associated with decreased P. falciparum parasitemia, downregulation of inflammatory cytokines, and enhanced antibody responses, potentially resulting in milder malaria episodes, suggesting enhanced protective immunity.{{Quote\|/indent}}		:{{Quote\|indent}}STH infections were associated with decreased P. falciparum parasitemia, downregulation of inflammatory cytokines, and enhanced antibody responses, potentially resulting in milder malaria episodes, suggesting enhanced protective immunity.{{Quote\|/indent}}

	* 2026 Mar 18 [https://pubmed.ncbi.nlm.nih.gov/41849415/ Coinfection with malaria alters the fecundity and within-host persistence of an intestinal nematode] ~~(Online ahead of print)~~		* 2026 Mar 18 [https://pubmed.ncbi.nlm.nih.gov/41849415/ Coinfection with malaria alters the fecundity and within-host persistence of an intestinal nematode]

	* 2026 [https://www.mdpi.com/2414-6366/11/2/46 There Is No Association Between Loiasis and Malaria: Findings from a Secondary Analysis of a Cross-Sectional Survey in Rural Gabon]		* 2026 [https://www.mdpi.com/2414-6366/11/2/46 There Is No Association Between Loiasis and Malaria: Findings from a Secondary Analysis of a Cross-Sectional Survey in Rural Gabon]