Helminthic Therapy wiki - Recent changes [en]

Mechanisms underlying helminth colonization

Jlm — Tue, 15 Sep 2026 17:00:33 GMT

Dendritic Cells

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	* 2004 Mar [https://pubmed.ncbi.nlm.nih.gov/15036034/ Alternatively activated macrophages during parasite infections]		* 2004 Mar [https://pubmed.ncbi.nlm.nih.gov/15036034/ Alternatively activated macrophages during parasite infections]

			* 2003 Oct [https://era.ed.ac.uk/items/e843d876-834b-4bd9-b03b-ec255cb66cdf Macrophages Activated by Type 2 Cytokines: Function and Gene Expression]

	* 2002 Jul [https://pubmed.ncbi.nlm.nih.gov/12065507/ Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability]		* 2002 Jul [https://pubmed.ncbi.nlm.nih.gov/12065507/ Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability]
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	=== Dendritic Cells ===		=== Dendritic Cells ===

			* 2026 Sep 7 [https://pubmed.ncbi.nlm.nih.gov/42705387/ Intestinal helminths skew dendritic cell development to counter the anti-helminth immune response]
	* 2026 Aug [https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.324/8744378 Allograft Inflammatory Factor 1 expression in cDC1 is required to direct Tbet—driven T cell immunity to defend against intracellular pathogens in vivo] (Conference, Immunology2026, Boston April 2026)		* 2026 Aug [https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.324/8744378 Allograft Inflammatory Factor 1 expression in cDC1 is required to direct Tbet—driven T cell immunity to defend against intracellular pathogens in vivo] (Conference, Immunology2026, Boston April 2026)
	* 2026 Feb 5 [https://www.biorxiv.org/content/10.64898/2026.02.03.703465v1 O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells] (Preprint)		* 2026 Feb 5 [https://www.biorxiv.org/content/10.64898/2026.02.03.703465v1 O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells] (Preprint)

Helminthic therapy and allergy

Jlm — Tue, 15 Sep 2026 16:48:06 GMT

Scientific papers

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	:* [[Helminthic therapy research \| '''Helminthic therapy research''']]		:* [[Helminthic therapy research \| '''Helminthic therapy research''']]

			* 2026 Dec [https://pubmed.ncbi.nlm.nih.gov/42702014/ The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases]
	* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]		* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]
	* 2026 Jun 5 [https://pubmed.ncbi.nlm.nih.gov/42327775/ Restoring Balance in Atopic Disorders: Insights into Type 2 Immunity and Chronic Inflammation] ("This article was funded by Sanofi and Regeneron Pharmaceuticals Inc")		* 2026 Jun 5 [https://pubmed.ncbi.nlm.nih.gov/42327775/ Restoring Balance in Atopic Disorders: Insights into Type 2 Immunity and Chronic Inflammation] ("This article was funded by Sanofi and Regeneron Pharmaceuticals Inc")

Helminthic therapy research

Jlm — Tue, 15 Sep 2026 16:47:39 GMT

2026

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	===2026===		===2026===

			* 2026 Dec [https://pubmed.ncbi.nlm.nih.gov/42702014/ The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases]
	* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]		* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]
	* 2026 Sep [https://academic.oup.com/ijnp/article/29/Supplement_1/i57/8789190 A macrobiotic treatment approach to alleviate chemotherapy-induced sickness and -cognitive disturbances] (Conference, Glasgow)		* 2026 Sep [https://academic.oup.com/ijnp/article/29/Supplement_1/i57/8789190 A macrobiotic treatment approach to alleviate chemotherapy-induced sickness and -cognitive disturbances] (Conference, Glasgow)

Mechanisms underlying helminth colonization

Jlm — Tue, 15 Sep 2026 16:47:24 GMT

Serine Protease Inhibitor (Serpins)

Self-treating with NA

Jlm — Tue, 15 Sep 2026 16:32:14 GMT

Checking whether inoculation was successful

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	* 2026 Dec [https://pubmed.ncbi.nlm.nih.gov/42384752/ Development and validation of the AI-predictive ParaScout in-vitro diagnostic (IVD) system for the microscopic detection of gastro-intestinal helminths in stool]		* 2026 Dec [https://pubmed.ncbi.nlm.nih.gov/42384752/ Development and validation of the AI-predictive ParaScout in-vitro diagnostic (IVD) system for the microscopic detection of gastro-intestinal helminths in stool]
			* 2026 Sep 8 [https://pubmed.ncbi.nlm.nih.gov/42711646/ ParasiteNet: Deep Learning-Based Identification of Parasitic Helminth Eggs in Microscopic Images]
	* 2026 Aug 6 [https://www.nepjol.info/index.php/JNGMC/article/view/98282 Efficacy of Stool Concentration Techniques versus Direct Wet Mount Microscopy in Detecting Intestinal Parasites: A Cross-Sectional Study at a Tertiary Care Hospital in Western Nepal]		* 2026 Aug 6 [https://www.nepjol.info/index.php/JNGMC/article/view/98282 Efficacy of Stool Concentration Techniques versus Direct Wet Mount Microscopy in Detecting Intestinal Parasites: A Cross-Sectional Study at a Tertiary Care Hospital in Western Nepal]
	* 2026 Aug 2 [https://jurnalfkip.unram.ac.id/index.php/JBT/article/view/12519 Difference Between Sucrose and NaCl Flotation Method for Detecting Soil-Transmitted Helminths (STH)]		* 2026 Aug 2 [https://jurnalfkip.unram.ac.id/index.php/JBT/article/view/12519 Difference Between Sucrose and NaCl Flotation Method for Detecting Soil-Transmitted Helminths (STH)]

Mechanisms underlying helminth colonization

Jlm — Mon, 14 Sep 2026 20:27:22 GMT

Serine Protease Inhibitor (Serpins)

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	=== Tuft cells ===		=== Tuft cells ===

			* 2026 Sep 8 [https://www.researchsquare.com/article/rs-10694790/v1 LXR is an epithelial transcriptional checkpoint that restrains mucosal type 2 immunity] (Preprint)
	* 2026 Aug 1 [https://pubmed.ncbi.nlm.nih.gov/42538852/ Interleukin-18 Constrains the Intestinal Tuft Cell-Driven Responses During Helminth Infection]		* 2026 Aug 1 [https://pubmed.ncbi.nlm.nih.gov/42538852/ Interleukin-18 Constrains the Intestinal Tuft Cell-Driven Responses During Helminth Infection]
	* 2026 Jul [https://pubmed.ncbi.nlm.nih.gov/42436595/ Influenza-induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice]		* 2026 Jul [https://pubmed.ncbi.nlm.nih.gov/42436595/ Influenza-induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice]
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	=== Group 2 innate lymphoid cells (ILC2s) ===		=== Group 2 innate lymphoid cells (ILC2s) ===

			* 2026 Sep 8 [https://www.researchsquare.com/article/rs-10694790/v1 LXR is an epithelial transcriptional checkpoint that restrains mucosal type 2 immunity] (Preprint)

	* 2026 Aug 28 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1878920/abstract ASNS-dependent Asparagine Availability Supports Intestinal ILC2 Responses and Type 2 Immunity under Nutrient-limited Conditions] (Online ahead of print)		* 2026 Aug 28 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1878920/abstract ASNS-dependent Asparagine Availability Supports Intestinal ILC2 Responses and Type 2 Immunity under Nutrient-limited Conditions] (Online ahead of print)
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	* 2025 Mar 13 [https://pubmed.ncbi.nlm.nih.gov/40082967/ Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis]		* 2025 Mar 13 [https://pubmed.ncbi.nlm.nih.gov/40082967/ Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis]

			* 2025 Mar 3 [https://pubmed.ncbi.nlm.nih.gov/40032982/ Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1]

	* 2025 Jan 11 [https://pubmed.ncbi.nlm.nih.gov/39799330/ Effects of Trichinella spiralis and its serine protease inhibitors on intestinal mucosal barrier function]		* 2025 Jan 11 [https://pubmed.ncbi.nlm.nih.gov/39799330/ Effects of Trichinella spiralis and its serine protease inhibitors on intestinal mucosal barrier function]

Helminthic therapy and cancer

Jlm — Mon, 14 Sep 2026 18:27:07 GMT

Chemotherapy and radiation therapy-induced pathologies

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	* [[Helminthic therapy and urologic disease#Chemotherapy-induced hemorrhagic cystitis \| '''Helminthic therapy and urologic disease: Chemotherapy-induced hemorrhagic cystitis''']]		* [[Helminthic therapy and urologic disease#Chemotherapy-induced hemorrhagic cystitis \| '''Helminthic therapy and urologic disease: Chemotherapy-induced hemorrhagic cystitis''']]

			* 2026 Sep [https://academic.oup.com/ijnp/article/29/Supplement_1/i57/8789190 A macrobiotic treatment approach to alleviate chemotherapy-induced sickness and -cognitive disturbances] (Conference, Glasgow)
	* 2026 Jan 10 [https://pubmed.ncbi.nlm.nih.gov/41567729/ First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia]		* 2026 Jan 10 [https://pubmed.ncbi.nlm.nih.gov/41567729/ First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia]
	* 2025 Dec 5 [https://pubmed.ncbi.nlm.nih.gov/41378248/ Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12687065/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12687065/pdf/wjbc-16-4-112221.pdf PDF]		* 2025 Dec 5 [https://pubmed.ncbi.nlm.nih.gov/41378248/ Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12687065/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12687065/pdf/wjbc-16-4-112221.pdf PDF]

Helminthic therapy research

Jlm — Mon, 14 Sep 2026 18:26:19 GMT

2026

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	* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]		* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]
			* 2026 Sep [https://academic.oup.com/ijnp/article/29/Supplement_1/i57/8789190 A macrobiotic treatment approach to alleviate chemotherapy-induced sickness and -cognitive disturbances] (Conference, Glasgow)
	* 2026 Sep [https://www.sciencedirect.com/science/article/pii/S0306987726002203 Gastro-oesophageal reflux disease as a disorder of immune dysregulation driven by microbial deprivation: Extending the hygiene hypothesis to the oesophagus] (Full text)		* 2026 Sep [https://www.sciencedirect.com/science/article/pii/S0306987726002203 Gastro-oesophageal reflux disease as a disorder of immune dysregulation driven by microbial deprivation: Extending the hygiene hypothesis to the oesophagus] (Full text)
	* 2026 Aug 28 [https://pubmed.ncbi.nlm.nih.gov/42664307/ Type I IFN-induced IFN-γ instructs monocyte-mediated systemic bacterial protection during type 2 intestinal helminth infection]		* 2026 Aug 28 [https://pubmed.ncbi.nlm.nih.gov/42664307/ Type I IFN-induced IFN-γ instructs monocyte-mediated systemic bacterial protection during type 2 intestinal helminth infection]

Helminthic therapy and allergy

Jlm — Mon, 14 Sep 2026 18:23:24 GMT

Scientific papers

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	:* [[Helminthic therapy research \| '''Helminthic therapy research''']]		:* [[Helminthic therapy research \| '''Helminthic therapy research''']]

	* 2026 ~~Jun 5~~ [https://~~www~~.~~frontiersin~~.~~org~~/~~journals~~/~~immunology~~/~~articles~~/10.~~3389/fimmu~~.~~2026~~.~~1793641~~/~~abstract~~ Restoring Balance in Atopic Disorders: Insights into Type 2 Immunity and Chronic Inflammation] ("This article was funded by Sanofi and Regeneron Pharmaceuticals Inc")		* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]
			* 2026 Jun 5 [https://pubmed.ncbi.nlm.nih.gov/42327775/ Restoring Balance in Atopic Disorders: Insights into Type 2 Immunity and Chronic Inflammation] ("This article was funded by Sanofi and Regeneron Pharmaceuticals Inc")
	* 2026 Feb [https://tjnpr.org/index.php/home/article/view/8092 Effects of Tissue Inhibitor Metalloproteinase-1 on Allergic Responses in Ovalbumin-induced Allergic Rhinitis Mice Model]		* 2026 Feb [https://tjnpr.org/index.php/home/article/view/8092 Effects of Tissue Inhibitor Metalloproteinase-1 on Allergic Responses in Ovalbumin-induced Allergic Rhinitis Mice Model]
	* 2025 Nov [https://academic.oup.com/jimmunol/article/214/Supplement_1/vkaf283.2214/8331728 Examining the immunomodulatory role of Heligmosomoides polygyrus bakeri (Hpb) in inducing tolerance to an oral allergen]		* 2025 Nov [https://academic.oup.com/jimmunol/article/214/Supplement_1/vkaf283.2214/8331728 Examining the immunomodulatory role of Heligmosomoides polygyrus bakeri (Hpb) in inducing tolerance to an oral allergen]

Helminthic therapy research

Jlm — Mon, 14 Sep 2026 18:22:21 GMT

2026

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	===2026===		===2026===

			* 2026 Sep 10 [https://pubmed.ncbi.nlm.nih.gov/42722802/ Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics]
	* 2026 Sep [https://www.sciencedirect.com/science/article/pii/S0306987726002203 Gastro-oesophageal reflux disease as a disorder of immune dysregulation driven by microbial deprivation: Extending the hygiene hypothesis to the oesophagus] (Full text)		* 2026 Sep [https://www.sciencedirect.com/science/article/pii/S0306987726002203 Gastro-oesophageal reflux disease as a disorder of immune dysregulation driven by microbial deprivation: Extending the hygiene hypothesis to the oesophagus] (Full text)
	* 2026 Aug 28 [https://pubmed.ncbi.nlm.nih.gov/42664307/ Type I IFN-induced IFN-γ instructs monocyte-mediated systemic bacterial protection during type 2 intestinal helminth infection]		* 2026 Aug 28 [https://pubmed.ncbi.nlm.nih.gov/42664307/ Type I IFN-induced IFN-γ instructs monocyte-mediated systemic bacterial protection during type 2 intestinal helminth infection]

Helminthic therapy and rheumatoid arthritis (RA)

Jlm — Mon, 14 Sep 2026 11:34:43 GMT

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	\|og:image=[[File:wiki.png]]}}		\|og:image=[[File:wiki.png]]}}
	[https://en.wikipedia.org/wiki/Rheumatoid_arthritis Rheumatoid arthritis] (RA) is a long-term autoimmune disorder that primarily affects joints.		[https://en.wikipedia.org/wiki/Rheumatoid_arthritis Rheumatoid arthritis] (RA) is a long-term autoimmune disorder that primarily affects joints.

			Here a good overview : [https://helminthictherapy.substack.com/p/helminthic-therapy-and-rheumatoid-arthritis Helminthic Therapy and Rheumatoid Arthritis: What the science says, what patients who practice it report, and why research must resume] (Jacques Le Marois, Helminthic Therapy news, Sep 9 2026)

	== The scientific evidence ==		== The scientific evidence ==

William Parker and helminthic therapy

John — Mon, 14 Sep 2026 02:28:00 GMT

Scientific publications by Parker and colleagues relating to helminthic therapy

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	* 2017 Jul [https://www.ncbi.nlm.nih.gov/pubmed/28720335 Not infection with parasitic worms, but rather colonization with therapeutic helminths] (no abstract) \| [[media:Not_infection_with_parasitic_worms_but_rather_colonization_with_therapeutic_helminths.pdf \| PDF]]		* 2017 Jul [https://www.ncbi.nlm.nih.gov/pubmed/28720335 Not infection with parasitic worms, but rather colonization with therapeutic helminths] (no abstract) \| [[media:Not_infection_with_parasitic_worms_but_rather_colonization_with_therapeutic_helminths.pdf \| PDF]]

			* 2017 May [http://www.ncbi.nlm.nih.gov/pubmed/27240605 Practices and outcomes of self-treatment with helminths based on physicians' observations] \| [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf \| PDF]]. This was the first study to examine, through the eyes of their physicians, the practices and experiences of those who are self-treating with helminths.

	* 2016 Jul [http://www.tandfonline.com/doi/full/10.1080/10601333.2016.1210159 Policy and regulations in light of the human body as a ‘superorganism’ containing multiple, intertwined symbiotic relationships] \| [[media:Policy and regulations in light of the human body as a ‘superorganism’ containing multiple, intertwined symbiotic relationships.pdf \| PDF]]		* 2016 Jul [http://www.tandfonline.com/doi/full/10.1080/10601333.2016.1210159 Policy and regulations in light of the human body as a ‘superorganism’ containing multiple, intertwined symbiotic relationships] \| [[media:Policy and regulations in light of the human body as a ‘superorganism’ containing multiple, intertwined symbiotic relationships.pdf \| PDF]]

	* 2016 May [http://www.ncbi.nlm.nih.gov/pubmed/27240605 Practices and outcomes of self-treatment with helminths based on physicians' observations] \| [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf \| PDF]]. This was the first study to examine, through the eyes of their physicians, the practices and experiences of those who are self-treating with helminths.

	* 2015 Jul [http://www.ncbi.nlm.nih.gov/pubmed/26162711 Got Worms? Perinatal Exposure to Helminths Prevents Persistent Immune Sensitization and Cognitive Dysfunction Induced by Early-Life Infection]		* 2015 Jul [http://www.ncbi.nlm.nih.gov/pubmed/26162711 Got Worms? Perinatal Exposure to Helminths Prevents Persistent Immune Sensitization and Cognitive Dysfunction Induced by Early-Life Infection]

Helminth providers

John — Mon, 14 Sep 2026 01:31:37 GMT

Nathural ★★★★★

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	Founded: 2022.<br>		Founded: 2022.<br>
	Organism supplied: [[Selecting a therapeutic helminth#NA (Necator americanus) \| NA]].<br>		Organism supplied: [[Selecting a therapeutic helminth#NA (Necator americanus) \| NA]].<br>
	<span style="color:purple">Ships (from France) to Europe (express), to the UK (tracked letter) and worldwide (letter or tracked letter).</span><br>		<span style="color:purple">Ships (from France) to Europe (express), to the UK (tracked letter) and worldwide (letter or tracked letter) except not currently to the US.</span><br>
	Payment is accepted via PayPal, credit card or [https://en.wikipedia.org/wiki/Bitcoin bitcoin].<br>		Payment is accepted via PayPal, credit card or [https://en.wikipedia.org/wiki/Bitcoin bitcoin].<br>
	Contact: Nathalie. Orders are done via their website (https://nalab.eu/).<br>		Contact: Nathalie. Orders are done via their website (https://nalab.eu/).<br>

Helminthic therapy research

Jlm — Sun, 13 Sep 2026 21:51:00 GMT

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	* [https://www.sciencedirect.com/science/article/pii/S1383576921002063?via%3Dihub Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy] (2022)<br>This study's findings suggested that information gathered by the helminthic therapy self-treatment community may be critical for public health in offering a solution to the helminth deficiency that is a fundamental cause of disease in Western society.		* [https://www.sciencedirect.com/science/article/pii/S1383576921002063?via%3Dihub Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy] (2022)<br>This study's findings suggested that information gathered by the helminthic therapy self-treatment community may be critical for public health in offering a solution to the helminth deficiency that is a fundamental cause of disease in Western society.

	* [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf \| Practices and outcomes of self-treatment with helminths based on physicians' observations]] (PDF) (~~2016~~)<br>The first study to examine, through the eyes of their physicians, the practices and experiences of individuals who are self-treating with helminths.		* [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf \| Practices and outcomes of self-treatment with helminths based on physicians' observations]] (PDF) (2017)<br>The first study to examine, through the eyes of their physicians, the practices and experiences of individuals who are self-treating with helminths.

	* [[media:Overcoming_Evolutionary_Mismatch_by_Self-Treatment_with_Helminths.pdf \| Overcoming Evolutionary Mismatch by Self-Treatment with Helminths: Current Practices and Experience]] (PDF) (2015)<br>This study probes the methods and outcomes reported by individuals who are self-treating with helminths and is an ideal basis for discussion between patients and their physicians.		* [[media:Overcoming_Evolutionary_Mismatch_by_Self-Treatment_with_Helminths.pdf \| Overcoming Evolutionary Mismatch by Self-Treatment with Helminths: Current Practices and Experience]] (PDF) (2015)<br>This study probes the methods and outcomes reported by individuals who are self-treating with helminths and is an ideal basis for discussion between patients and their physicians.

Helminthic therapy and neuropsychiatric disorders

Jlm — Sun, 13 Sep 2026 21:50:15 GMT

The scientific evidence

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	* 2018 Aug 15 [https://www.ncbi.nlm.nih.gov/pubmed/29402395 Intestinal worms eating neuropsychiatric disorders? Apparently so] -- [[media:Intestinal_worms_eating_neuropsychiatric_disorders%3F_Apparently_so.pdf \| PDF]]		* 2018 Aug 15 [https://www.ncbi.nlm.nih.gov/pubmed/29402395 Intestinal worms eating neuropsychiatric disorders? Apparently so] -- [[media:Intestinal_worms_eating_neuropsychiatric_disorders%3F_Apparently_so.pdf \| PDF]]

			* ✅ ⚡ 2017 May [http://www.ncbi.nlm.nih.gov/pubmed/27240605 Practices and outcomes of self-treatment with helminths based on physicians' observations] -- [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf \| PDF]]. The first study to probe, through the eyes of their physicians, the practices and experiences of those who are self-treating with helminths.

	* 2016 Sep [https://pubmed.ncbi.nlm.nih.gov/27436048/ The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC5763918/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC5763918/pdf/nihms-804488.pdf PDF]		* 2016 Sep [https://pubmed.ncbi.nlm.nih.gov/27436048/ The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC5763918/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC5763918/pdf/nihms-804488.pdf PDF]

	* ✅ ⚡ 2016 May 31 [http://www.ncbi.nlm.nih.gov/pubmed/27240605 Practices and outcomes of self-treatment with helminths based on physicians' observations] -- [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf \| PDF]]. The first study to probe, through the eyes of their physicians, the practices and experiences of those who are self-treating with helminths.

	* 2014 Jun [http://www.ncbi.nlm.nih.gov/pubmed/24997041 Microbiota, immunoregulatory old friends and psychiatric disorders]		* 2014 Jun [http://www.ncbi.nlm.nih.gov/pubmed/24997041 Microbiota, immunoregulatory old friends and psychiatric disorders]

Helminthic therapy and neurodevelopmental disorders

Jlm — Sun, 13 Sep 2026 21:21:57 GMT

Attention deficit hyperactivity disorder (ADHD, ADD)

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	== Attention deficit hyperactivity disorder (ADHD, ADD) ==		== Attention deficit hyperactivity disorder (ADHD, ADD) ==

	* 2026 Feb 28 [https://jsocmed.org/index.php/go/article/view/274 Zero Prevalence of Soil-Transmitted Helminth Infections among Students with Disabilities and Symptoms of Attention-Deficit/Hyperactivity Disorder in Bengkulu City, Indonesia]

	* 2026 Jan 14 [https://pubmed.ncbi.nlm.nih.gov/41613259/ Rethinking ADHD as a neurointestinal syndrome: a gut-brain-parasite hypothesis] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12847369/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12847369/pdf/fnins-19-1694628.pdf PDF]		* 2026 Jan 14 [https://pubmed.ncbi.nlm.nih.gov/41613259/ Rethinking ADHD as a neurointestinal syndrome: a gut-brain-parasite hypothesis] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12847369/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12847369/pdf/fnins-19-1694628.pdf PDF]

	* 2025 Dec [https://pubmed.ncbi.nlm.nih.gov/40719366/ Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12309550/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12309550/pdf/KGMI_17_2537755.pdf PDF]		* 2025 Dec [https://pubmed.ncbi.nlm.nih.gov/40719366/ Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12309550/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12309550/pdf/KGMI_17_2537755.pdf PDF]

	* 2025 Nov 19 [https://pubmed.ncbi.nlm.nih.gov/41346685/ The impact of trans fatty acids on ADHD in relation to the gut microbiome] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12673567/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12673567/pdf/fnut-12-1641574.pdf PDF]

	Personal story:		Personal story:

	* “My adult son with ADD tried them (NA) and was able to cut his stimulants in half.” [https://www.facebook.com/groups/htsupport/permalink/3003258209730114/?comment_id=3003295283059740&reply_comment_id=3005744796148122]		* “My adult son with ADD tried them (NA) and was able to cut his stimulants in half.” [https://www.facebook.com/groups/htsupport/permalink/3003258209730114/?comment_id=3003295283059740&reply_comment_id=3005744796148122]

			See also

			* 2026 Feb 28 [https://jsocmed.org/index.php/go/article/view/274 Zero Prevalence of Soil-Transmitted Helminth Infections among Students with Disabilities and Symptoms of Attention-Deficit/Hyperactivity Disorder in Bengkulu City, Indonesia]
			* 2025 Nov 19 [https://pubmed.ncbi.nlm.nih.gov/41346685/ The impact of trans fatty acids on ADHD in relation to the gut microbiome] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12673567/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12673567/pdf/fnut-12-1641574.pdf PDF]

	== Neurofibromatosis type I ==		== Neurofibromatosis type I ==

Helminthic therapy in the media

John — Sun, 13 Sep 2026 02:26:08 GMT

Articles

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	'''2026'''		'''2026'''

			* 2026 Sep 12 [https://www.smh.com.au/national/why-alex-infected-himself-with-blood-sucking-hookworms-and-kept-them-20260828-p60sd3.html Why Alex infected himself with blood-sucking hookworms, and kept them] Angus Dalton, The Sunday Morning Herald (Currently behind a paywall)

	* 2026 Sep 09 [https://helminthictherapy.substack.com/p/helminthic-therapy-and-rheumatoid-arthritis? Helminthic Therapy and Rheumatoid Arthritis] - Jacques Le Marois, Helminthic Therapy news, Substack		* 2026 Sep 09 [https://helminthictherapy.substack.com/p/helminthic-therapy-and-rheumatoid-arthritis? Helminthic Therapy and Rheumatoid Arthritis] - Jacques Le Marois, Helminthic Therapy news, Substack

Helminth incubation

John — Sat, 12 Sep 2026 18:28:16 GMT

The risk of attracting damaging publicity

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	Yet another often overlooked issue is the risk of legal action against a donor of hookworms or hookworm-infected materials.		Yet another often overlooked issue is the risk of legal action against a donor of hookworms or hookworm-infected materials.

	The donation of larvae or infected faeces could expose the person supplying them to legal action by the recipient’s relatives in the event of that recipient dying after using the donated material. The grieving relatives might sue the donor in the belief, whether right or wrong, that the donation was somehow responsible for the death of their loved one. Someone contemplating the use of donated materials may think that their relatives would never react in this way, but death can spark unpredictable and irrational behaviour in family members, and the fact that the organisms had been given away rather than being sold would not necessarily free the donor of liability. The outcome of such a scenario would only be revealed after it had been tested in a court of law, and this could be a very costly and stressful process for all those involved.		The donation of larvae or infected faeces could expose the person supplying them to legal action by the recipient’s relatives in the event of that recipient dying after using the donated material. The grieving relatives might sue the donor in the belief, whether right or wrong, that the donation was somehow responsible for the death of their loved one. Someone contemplating the use of donated materials may think that their relatives would never react in this way, but death can spark unpredictable and irrational behaviour in family members, and the fact that the organisms had been given away rather than being sold would not necessarily free the donor of liability. The outcome of such a scenario would only be revealed after it had been tested in a court of law, and this could be a very lengthy, costly and stressful process for all those involved.

	==== The risk of attracting damaging publicity ====		==== The risk of attracting damaging publicity ====

	There are some people who choose the DIY hookworm culture route because they object to having to pay for the treatment, even though the cost of a dose of hookworm larvae is now minimal. Unfortunately, the sometimes reckless attitude displayed by some ~~in this group~~ not only threatens their own safety and possibly that of those around them, but could also have much wider implications.		There are some people who choose the DIY hookworm culture route because they object to having to pay for the treatment, even though the cost of a dose of hookworm larvae is now minimal. Unfortunately, the sometimes reckless attitude displayed by some individuals not only threatens their own safety and possibly that of those around them, but could also have much wider implications.

	A number of reports have already surfaced about people who have successfully incubated hookworm larvae but, then, due to a failure to carry out the appropriate research, sloppy technique, undue haste, or just plain carelessness, have taken unbelievable risks with their health. One individual attempted to collect larvae for inoculation without a microscope, using only a magnifying glass. Others have chosen not to even bother counting out a number of larvae with which to inoculate, and, in one case, someone who had incubated larvae proceeded to smear faeces from the sample, along with liquid from its container, directly onto his skin, potentially giving himself a dose of hundreds, if not thousands of hookworms!		A number of reports have already surfaced about people who have successfully incubated hookworm larvae but, then, due to a failure to carry out the appropriate research, sloppy technique, undue haste, or just plain carelessness, have taken unbelievable risks with their health. One individual attempted to collect larvae for inoculation without a microscope, using only a magnifying glass. Others have chosen not to even bother counting out a number of larvae with which to inoculate, and, in one case, someone who had incubated larvae proceeded to smear faeces from the sample, along with liquid from its container, directly onto his skin, potentially giving himself a dose of hundreds, if not thousands of hookworms!

Medical conditions and their response to helminthic therapy

Jlm — Sat, 12 Sep 2026 06:19:51 GMT

Medical conditions

File:Notes for prospective helminth providers.pdf

John — Sat, 12 Sep 2026 01:23:22 GMT

John deleted page File:Notes for prospective helminth providers.pdf

Helminthic therapy in the media

John — Thu, 10 Sep 2026 18:38:14 GMT

Articles

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	'''2026'''		'''2026'''

			* 2026 Sep 09 [https://helminthictherapy.substack.com/p/helminthic-therapy-and-rheumatoid-arthritis? Helminthic Therapy and Rheumatoid Arthritis] - Jacques Le Marois, Helminthic Therapy news, Substack

			* 2026 Sep 07 [https://helminthictherapy.substack.com/p/helminths-covid-19 The Protective Effect of Helminths Against COVID-19: How the African Paradox Was Solved] - Jacques Le Marois, Helminthic Therapy news, Substack

	* 2026 Aug 26 [https://helminthictherapy.substack.com/p/helminths-cadmium Helminths, an Unexpected Ally Against Cadmium?] - Jacques Le Marois, Helminthic Therapy news, Substack		* 2026 Aug 26 [https://helminthictherapy.substack.com/p/helminths-cadmium Helminths, an Unexpected Ally Against Cadmium?] - Jacques Le Marois, Helminthic Therapy news, Substack

Helminthic therapy and infectious diseases

Jlm — Wed, 09 Sep 2026 12:45:35 GMT

Helminths and Escherichia coli

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	* 2011 Apr [https://pubmed.ncbi.nlm.nih.gov/21245271/ The pathogenicity of an enteric Citrobacter rodentium Infection is enhanced by deficiencies in the antioxidants selenium and vitamin E] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3067545/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3067545/pdf/1017-10.pdf PDF]		* 2011 Apr [https://pubmed.ncbi.nlm.nih.gov/21245271/ The pathogenicity of an enteric Citrobacter rodentium Infection is enhanced by deficiencies in the antioxidants selenium and vitamin E] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3067545/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3067545/pdf/1017-10.pdf PDF]
	* 2008 Apr [https://d1wqtxts1xzle7.cloudfront.net/47378268/s0016-5085_2808_2960216-420160720-23939-18dbtzp-libre.pdf?1469022993=&response-content-disposition=inline%3B+filename%3D313_Glutamine_Regulates_Autophagy_in_IEC.pdf&Expires=1764709114&Signature=ZSIUgvKefhmHOP0YClnxDjsgZtZyp94lIzhS9YTEu~iG6uFSuaPv2IjEcyLVBPS1r~qmwFqAOu2aBUN~4fcFWOwrwZhMOEq~BYELox4iaOJe0rOUnM3wcrQkZrzdHxd7Owr0KSO4tN4OsS5WEzPv~4dJdrOKqe6coD9XhSJEYnsD7chlCNgngBaSaYFGev4EJfcItY~g2rH2PTAuQ0MCkZQ1byynAWgUWfGgytacdS4uhzpKkIjE3WgvDKCkBGRNIvf2GZyBmxMg9dF-yE1Y88FfaNnJizLhj6OTmnW~QzFW2ei8AIC5OaX9TqcSNrSP78T7DbfXfwviPwBHnzzxXg__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA The Pathogenicity of Citrobacter rodentium (CR) Is Enhanced in Mice Fed Diets Deficient in Selenium (Se) and Vitamin E (VE)]		* 2008 Apr [https://d1wqtxts1xzle7.cloudfront.net/47378268/s0016-5085_2808_2960216-420160720-23939-18dbtzp-libre.pdf?1469022993=&response-content-disposition=inline%3B+filename%3D313_Glutamine_Regulates_Autophagy_in_IEC.pdf&Expires=1764709114&Signature=ZSIUgvKefhmHOP0YClnxDjsgZtZyp94lIzhS9YTEu~iG6uFSuaPv2IjEcyLVBPS1r~qmwFqAOu2aBUN~4fcFWOwrwZhMOEq~BYELox4iaOJe0rOUnM3wcrQkZrzdHxd7Owr0KSO4tN4OsS5WEzPv~4dJdrOKqe6coD9XhSJEYnsD7chlCNgngBaSaYFGev4EJfcItY~g2rH2PTAuQ0MCkZQ1byynAWgUWfGgytacdS4uhzpKkIjE3WgvDKCkBGRNIvf2GZyBmxMg9dF-yE1Y88FfaNnJizLhj6OTmnW~QzFW2ei8AIC5OaX9TqcSNrSP78T7DbfXfwviPwBHnzzxXg__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA The Pathogenicity of Citrobacter rodentium (CR) Is Enhanced in Mice Fed Diets Deficient in Selenium (Se) and Vitamin E (VE)]

			See also [[Helminthic therapy personal stories#Urinary tract infections (UTIs) \| Helminthic therapy personal stories: Urinary tract infections (UTIs)]]

	=== Helminths and leprosy ===		=== Helminths and leprosy ===

Helminthic therapy and neurodegenerative diseases

Jlm — Wed, 09 Sep 2026 12:07:22 GMT

Inflammation

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	* 2026 Apr 23 [https://pubmed.ncbi.nlm.nih.gov/42024796/ Alcohol and neurodegenerative diseases: a review of mechanistic insights and disease specific effects]		* 2026 Apr 23 [https://pubmed.ncbi.nlm.nih.gov/42024796/ Alcohol and neurodegenerative diseases: a review of mechanistic insights and disease specific effects]

	* 2026 Mar 26 [https://pubmed.ncbi.nlm.nih.gov/41888134/ Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife] ~~(Online ahead of print)~~		* 2026 Mar 26 [https://pubmed.ncbi.nlm.nih.gov/41888134/ Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife]

	* 2026 Feb 24 [https://pubmed.ncbi.nlm.nih.gov/41581145/ C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen] (ALS)		* 2026 Feb 24 [https://pubmed.ncbi.nlm.nih.gov/41581145/ C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen] (ALS)

Introduction to helminthic therapy

John — Tue, 08 Sep 2026 20:37:16 GMT

Further information

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	== Further information ==		== Further information ==
	Google's search engine is best avoided when looking for information about any natural health treatment such as helminthic therapy because Google favours mainstream, mainly pharmaceutical approaches to healthcare and actively disparages sources of information about non-pharmaceutical solutions. Even Google's academic search service, Google Scholar, effectively suppresses many natural‑health ~~papers~~ in favor of conventional pharmaceutical literature. [https://web.archive.org/web/20260207143454/https://mindmatters.ai/2025/05/how-google-search-rank-disrupted-the-alternative-health-industry/] (Web archive copy)		Google's search engine is best avoided when looking for information about any natural health treatment such as helminthic therapy because Google favours mainstream, mainly pharmaceutical approaches to healthcare and actively disparages sources of information about non-pharmaceutical solutions. Even Google's academic search service, Google Scholar, effectively suppresses many natural‑health informaion sources in favor of conventional pharmaceutical literature. [https://web.archive.org/web/20260207143454/https://mindmatters.ai/2025/05/how-google-search-rank-disrupted-the-alternative-health-industry/] (Web archive copy)

	Prominant among the sites ranked most highly by Google are the larger general health information websites, which carry pages about helminthic therapy. Unfortunately, these pages have invariably been written, and reviewed, by staff members who have no personal experience of helminthic therapy, so have turned for information to the evidence presented by the authors of clinical trials, which, in the case of this particular therapy, are mostly seriously flawed, as is explained here: [[Helminthic therapy clinical trials and observational studies#Problems with clinical trials using live helminths \| '''Problems with clinical trials using live helminths''']].		Prominant among the sites ranked most highly by Google are the larger general health information websites, which carry pages about helminthic therapy. Unfortunately, these pages have invariably been written, and reviewed, by staff members who have no personal experience of helminthic therapy, so have turned for information to the evidence presented by the authors of clinical trials, which, in the case of this particular therapy, are mostly seriously flawed, as is explained here: [[Helminthic therapy clinical trials and observational studies#Problems with clinical trials using live helminths \| '''Problems with clinical trials using live helminths''']].

	An example of this is the article on the ''Healthline'' website entitled, [http://www.healthline.com/health/crohns-disease/hook-worms#1 Helminthic Treatment for Crohn's Disease]. This speaks of worm eggs being “injected” into patients, and of helminths causing dangerous side effects over time, including anaemia, protein deficiency and stunted growth. ~~However~~, not one of these claims is true in the case of the four species of ''mutualistic'' helminth that are used in small numbers in helminthic therapy, as can be seen from the following wiki pages.		An example of this is the article on the ''Healthline'' website entitled, [http://www.healthline.com/health/crohns-disease/hook-worms#1 Helminthic Treatment for Crohn's Disease]. This speaks of worm eggs being “injected” into patients, and of helminths causing dangerous side effects over time, including anaemia, protein deficiency and stunted growth. In reality, not one of these claims is true in the case of the four species of ''mutualistic'' helminth that are used in small numbers in helminthic therapy, as can be seen from the following wiki pages.

	* [[Helminthic therapy safety \| '''Helminthic therapy safety''']]		* [[Helminthic therapy safety \| '''Helminthic therapy safety''']]
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	* [[Helminth inoculation \| '''Helminth inoculation''']]		* [[Helminth inoculation \| '''Helminth inoculation''']]

	Editors of this wiki have made several attempts to have the errors in the Healthline article corrected, but no one from Healthline has ever responded to any communication about the article. Unfortunately, this is typical for most of the large health information websites, many of which are controlled by pharmaceutical companies~~, their employees~~ or their ~~representatives~~.		Editors of this wiki have made several attempts to have the errors in the Healthline article corrected, but no one from Healthline has ever responded to any communication about the article. Unfortunately, this is typical for most of the large health information websites, many of which are controlled by pharmaceutical companies or their associates.

	In view of ~~these~~ issues with mainstream online health sites, and search engines such as Google, anyone seeking information about helminthic therapy is urged to use this wiki as their primary source. It is the definitive database of information about all aspects of the therapy, presenting information gleaned from the best of the available science and from ~~reports of~~ the personal experience of helmnth self-treaters~~. The site is continually updated by volunteer citizen scientists who are personally involved in pioneering its use~~.		The information about helminthic therapy presented in Wikipedia [https://en.wikipedia.org/wiki/Helminthic_therapy] is largely limited by Wikipedia's editorial policy to what has been written in clinical trial reports. Consequently, this source repeats a significant number of the researchers' misconceptions and factual errors, and these have proved impossible to correct as a result of the insistnece of Wikipedia's controllers on the exclusive reliance on data from clinical trials and their refusal to allow outside edits that differ from this source. The representation of helminthic therapy in the largely AI-generated Grokipedia [https://grokipedia.com/page/Helminthic_therapy#ref-9] is also flawed as a result of it laundering details from the same published literature, now dressed in the costume of encyclopedic authority.

			In view of the issues with mainstream online health sites and encyclopedias, and with search engines such as Google, anyone seeking information about helminthic therapy is urged to use this wiki as their primary source. It is the definitive database of information about all aspects of the therapy, presenting information gleaned from the best of the available science and from the personal experience of those who collectivly know most about this subject - helmnth self-treaters.

	Another information site that is free from industry bias is the [https://helminthictherapy.substack.com Helminthic Therapy news Substack].		Another information site that is free from industry bias is the [https://helminthictherapy.substack.com Helminthic Therapy news Substack].

Helminthic therapy and allergy

John — Mon, 07 Sep 2026 23:15:42 GMT

Show changes

Helminthic therapy and asthma

John — Mon, 07 Sep 2026 23:09:49 GMT

The scientific evidence

Show changes

Helminthic therapy and allergy

John — Mon, 07 Sep 2026 14:10:17 GMT

Scientific papers

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	=== Scientific papers ===		=== Scientific papers ===

	There are numerous studies on allergies that use a rodent models involving ‘allergic airway inflammation’. These studies are listed on [[Helminthic therapy and asthma \| the asthma page]]. It is therefore also necessary to consult these studies to gain a complete understanding of the effect of helminths on allergies.		There are numerous studies on allergies that use rodent models involving ‘allergic airway inflammation’. These studies are listed on [[Helminthic therapy and asthma \| the asthma page]]. It is therefore also necessary to consult these studies to gain a complete understanding of the effect of helminths on allergies.

	:See also		:See also

Helminthic therapy and eczema

John — Mon, 07 Sep 2026 14:07:52 GMT

Show changes

Human helminth care manual

John — Mon, 07 Sep 2026 01:15:06 GMT

Spices and culinary herbs

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	<span id="Oregano"></span>		<span id="Oregano"></span>
	* ❌ [https://en.wikipedia.org/wiki/Oregano Oregano] (Origanum vulgare). Oregano oil, which contains isomeric phenols (primarily carvacrol but also including thymol and limonene), can destroy a number of bacteria, fungi and viruses in dilutions as low as 1/50,000, and is also antiparasitic. It is reported to be effective against protozoan parasites in particular as well as roundworm larvae, and somewhat effective against tapeworms. In one study [http://www.chirochat.org/article_files/Article-2953.pdf], 57 per cent of adults with intestinal parasites who were treated with 600 mg of oregano oil daily for six weeks experienced total eradication of their parasites. Several hosts of therapeutic helminths have reported adverse effects on their worms after ingesting oregano oil and, in at least two cases, it has resulted in a total loss of worms. However, one subject, who took oil of ''wild'' oregano sublingually twice each day for 2 weeks had a stool test sometime after this that was positive for hookworms, so perhaps either the wild form of the herb, or the sublingual route, helped reduce the effect on the worms in this case. Some foods, particularly soft cheeses, may be coated with an [http://www.sciencedaily.com/releases/2014/11/141127082311.htm antimicrobial film incorporating oregano oil] to increase their lifespan, but the amount of oregano involved in this application is unlikely to be a serious threat to helminths. A few '''oregano ''leaves''''' eaten with food are less likely to be harmful to human helminths ~~[https://www.facebook.com/groups/htsupport/permalink/2545907775465162/?comment_id=2545955292127077]~~, but one host of both hookworms and whipworms has reported that, while there was no immediate effect on his worms when he applied a ''heavy'' sprinkling of oregano leaf powder to his food a couple of times in a day, he was later plunged into such a self-critical and depressed mood that, before eventually regaining his usual mental balance, he struggled to do any work for several days.		* ❌ [https://en.wikipedia.org/wiki/Oregano Oregano] (Origanum vulgare). Oregano oil, which contains isomeric phenols (primarily carvacrol but also including thymol and limonene), can destroy a number of bacteria, fungi and viruses in dilutions as low as 1/50,000, and is also antiparasitic. It is reported to be effective against protozoan parasites in particular as well as roundworm larvae, and somewhat effective against tapeworms. In one study [http://www.chirochat.org/article_files/Article-2953.pdf], 57 per cent of adults with intestinal parasites who were treated with 600 mg of oregano oil daily for six weeks experienced total eradication of their parasites. Several hosts of therapeutic helminths have reported adverse effects on their worms after ingesting oregano oil and, in at least two cases, it has resulted in a total loss of worms. However, one subject, who took oil of ''wild'' oregano sublingually twice each day for 2 weeks had a stool test sometime after this that was positive for hookworms, so perhaps either the wild form of the herb, or the sublingual route, helped reduce the effect on the worms in this case. Some foods, particularly soft cheeses, may be coated with an [http://www.sciencedaily.com/releases/2014/11/141127082311.htm antimicrobial film incorporating oregano oil] to increase their lifespan, but the amount of oregano involved in this application is unlikely to be a serious threat to helminths. A few '''oregano ''leaves''''' eaten with food are less likely to be harmful to human helminths (link expired), but one host of both hookworms and whipworms has reported that, while there was no immediate effect on his worms when he applied a ''heavy'' sprinkling of oregano leaf powder to his food a couple of times in a day, he was later plunged into such a self-critical and depressed mood that, before eventually regaining his usual mental balance, he struggled to do any work for several days.

	* ✅ [https://en.wikipedia.org/wiki/Saffron Saffron] This spice is derived from the flower of crocus sativus, commonly known as the "saffron crocus". (See separate entry for this herb.) One hookworm host took a supplement containing turmeric and saffron for 6 weeks without any adverse effect on her colony. [https://www.facebook.com/groups/htsupport/permalink/2129639990425278/]		* ✅ [https://en.wikipedia.org/wiki/Saffron Saffron] This spice is derived from the flower of crocus sativus, commonly known as the "saffron crocus". (See separate entry for this herb.) One hookworm host took a supplement containing turmeric and saffron for 6 weeks without any adverse effect on her colony. [https://www.facebook.com/groups/htsupport/permalink/2129639990425278/]

Helminthic therapy and COVID-19

Jlm — Sat, 05 Sep 2026 08:49:30 GMT

The scientific evidence

Helminthic therapy and COVID-19

John — Fri, 04 Sep 2026 13:25:21 GMT

The scientific evidence

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	* 2025 Jun 16 [https://pubmed.ncbi.nlm.nih.gov/40611777/ Marginal cytokine modulation by Schistosoma mansoni soluble egg antigen in SARS-CoV-2-infected K18-hACE2 mice]		* 2025 Jun 16 [https://pubmed.ncbi.nlm.nih.gov/40611777/ Marginal cytokine modulation by Schistosoma mansoni soluble egg antigen in SARS-CoV-2-infected K18-hACE2 mice]

	* 2025 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/40266113/ Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19]		* 2025 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/40266113/ Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11946601/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11946601/pdf/vaccines-13-00252.pdf PDF]
	:{{Quote\|indent}}These data suggest that co-exposure to helminths could mitigate the severity of COVID-19 outcomes by reducing the Th1 and Th17 responses{{Quote\|/indent}}		:{{Quote\|indent}}These data suggest that co-exposure to helminths could mitigate the severity of COVID-19 outcomes by reducing the Th1 and Th17 responses{{Quote\|/indent}}

Helminthic therapy research

John — Fri, 04 Sep 2026 13:12:36 GMT

2025

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	* 2025 Mar [https://pubmed.ncbi.nlm.nih.gov/39952796/ Helminths target macrophage epigenetics and metabolism to evade immunity]		* 2025 Mar [https://pubmed.ncbi.nlm.nih.gov/39952796/ Helminths target macrophage epigenetics and metabolism to evade immunity]

	* 2025 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/~~40266113~~/ ~~Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID~~-19]		* 2025 Feb 28 [https://pubmed.ncbi.nlm.nih.gov/39950309/ An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM-1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11826375/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11826375/pdf/FSB2-39-e70380.pdf PDF] (see [https://www.linkedin.com/posts/applied-molecular-parasitology-lab-ampl-dalton-lab_biotherapeutics-immunemodulation-healthinnovation-activity-7302379555372052483-kkzP/ Linkedin post])

	* 2025 Feb 28 [https://pubmed.ncbi.nlm.nih.gov/~~39950309~~/ ~~An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM~~-~~1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/~~PMC11826375~~/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/~~PMC11826375~~/pdf/~~FSB2~~-39-~~e70380~~.pdf PDF] ~~(see [https://www.linkedin.com/posts/applied-molecular-parasitology-lab-ampl-dalton-lab_biotherapeutics-immunemodulation-healthinnovation-activity-7302379555372052483-kkzP/ Linkedin post])~~		* 2025 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/40266113/ Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11946601/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11946601/pdf/vaccines-13-00252.pdf PDF]

	* 2025 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/40014218/ Clonorchis sinensis Infection prevents DSS-induced Colitis Via Lithocholic Acid in a Gut Microbiota-Dependent Manner] -- [https://link.springer.com/article/10.1007/s10753-025-02241-4 Full text]		* 2025 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/40014218/ Clonorchis sinensis Infection prevents DSS-induced Colitis Via Lithocholic Acid in a Gut Microbiota-Dependent Manner] -- [https://link.springer.com/article/10.1007/s10753-025-02241-4 Full text]

	* 2025 Feb 25 [https://pubmed.ncbi.nlm.nih.gov/40266113/ Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19] -- [https://pmc.ncbi.nlm.nih.gov/articles/pmid/40266113/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11946601/pdf/vaccines-13-00252.pdf PDF]

	* 2025 Feb 25 [https://link.springer.com/chapter/10.1007/978-3-031-84877-3_4 Diseases Deriving from Alterations of the Ecological Niche—Part II: Regarding the Holobiont]		* 2025 Feb 25 [https://link.springer.com/chapter/10.1007/978-3-031-84877-3_4 Diseases Deriving from Alterations of the Ecological Niche—Part II: Regarding the Holobiont]

← Older revision		Revision as of 06:19, 12 September 2026
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	* Keratosis pilaris: [[Helminthic therapy personal stories#Keratosis pilaris \| PS]]		* Keratosis pilaris: [[Helminthic therapy personal stories#Keratosis pilaris \| PS]]
	* Kidney pathology: [[Helminthic therapy personal stories#Kidney pathology \| PS]]		* Kidney pathology: [[Helminthic therapy personal stories#Kidney pathology \| PS]]
	* Kleine-Levin syndrome (KLS): Helminthic therapy and neuropsychiatric disorders#Kleine-Levin syndrome (KLS) \| PTE]]		* Kleine-Levin syndrome (KLS): [[Helminthic therapy and neuropsychiatric disorders#Kleine-Levin syndrome (KLS) \| PTE]]
	* Kuru disease: [[Helminthic therapy and infectious diseases#Helminths and prion diseases \| SE]]		* Kuru disease: [[Helminthic therapy and infectious diseases#Helminths and prion diseases \| SE]]
	* Labyrinthitis: [[Helminthic therapy personal stories#Labyrinthitis \| PS]]		* Labyrinthitis: [[Helminthic therapy personal stories#Labyrinthitis \| PS]]
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	* Postural orthostatic tachycardia syndrome (POTS): [[Helminthic therapy and postural orthostatic tachycardia syndrome (POTS) \| PS]]		* Postural orthostatic tachycardia syndrome (POTS): [[Helminthic therapy and postural orthostatic tachycardia syndrome (POTS) \| PS]]
	* Powassan virus: ❓ [[Helminthic therapy and infectious diseases#Helminths and flaviviruses \| PNE]]		* Powassan virus: ❓ [[Helminthic therapy and infectious diseases#Helminths and flaviviruses \| PNE]]
	* Preeclampsia		* Preeclampsia: [[Helminthic therapy for well people#Preeclampsia \| PTE]]
	* Premature birth		* Premature birth: [[Helminthic therapy for well people#Premature birth \| PTE]]
	* Premenstrual Syndrome (PMS): [[Helminthic therapy and women's health#Premenstrual syndrome (PMS) \| PS]]		* Premenstrual Syndrome (PMS): [[Helminthic therapy and women's health#Premenstrual syndrome (PMS) \| PS]]
	* Primary adrenal insufficiency		* Primary adrenal insufficiency
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	* Stiff-person syndrome (SPS): [[Helminthic therapy and neuromuscular disorders#Stiff-person syndrome (SPS) \| PTE]]		* Stiff-person syndrome (SPS): [[Helminthic therapy and neuromuscular disorders#Stiff-person syndrome (SPS) \| PTE]]
	* Still's Disease: [[Helminthic therapy and arthritis \| PTE]]		* Still's Disease: [[Helminthic therapy and arthritis \| PTE]]
	* Stomach acid		* Stomach acid: [[Helminthic therapy personal stories#Hypochlorhydria / low stomach acid \| PS]]
	* Streptococcus pneumoniae pulmonary infection: ❓ [[Helminthic therapy and infectious diseases#Helminths and Streptococcus pneumoniae \| PNE]]		* Streptococcus pneumoniae pulmonary infection: ❓ [[Helminthic therapy and infectious diseases#Helminths and Streptococcus pneumoniae \| PNE]]
	* Stress: [[Helminthic therapy personal stories#Stress \| PS]]		* Stress: [[Helminthic therapy personal stories#Stress \| PS]]

← Older revision		Revision as of 08:49, 5 September 2026
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	* 2022 [https://pubmed.ncbi.nlm.nih.gov/37573497/ Role of neglected parasitic diseases in the era of COVID-19 pandemics]		* 2022 [https://pubmed.ncbi.nlm.nih.gov/37573497/ Role of neglected parasitic diseases in the era of COVID-19 pandemics]

	* 2021 Dec 6 [https://evmedreview.com/evolutionary-medicine-helps-explain-pandemic-dynamics-predictions-regarding-clinical-impact-of-covid-19-borne-out/ Evolutionary medicine helps explain pandemic dynamics: Predictions regarding clinical impact of COVID-19 borne out]		* 2021 Dec 6 [https://evmedreview.com/evolutionary-medicine-helps-explain-pandemic-dynamics-predictions-regarding-clinical-impact-of-covid-19-borne-out/ Evolutionary medicine helps explain pandemic dynamics: Predictions regarding clinical impact of COVID-19 borne out] ([https://web.archive.org/web/20220127112859/https://evmedreview.com/evolutionary-medicine-helps-explain-pandemic-dynamics-predictions-regarding-clinical-impact-of-covid-19-borne-out/ archive.org version])

	::A significant amount of the tragic clinical outcome of the COVID pandemic in high-income countries might arguably have been mitigated had timely investigations been carried out into the effects of the loss of helminths and protists in these countries and into the reintroduction of benign species capable of safely modulating immune function.		::A significant amount of the tragic clinical outcome of the COVID pandemic in high-income countries might arguably have been mitigated had timely investigations been carried out into the effects of the loss of helminths and protists in these countries and into the reintroduction of benign species capable of safely modulating immune function.
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	::(Related media article: [https://www.news-medical.net/news/20210204/Research-shows-intestinal-parasite-infestations-reduce-COVID-19-severity.aspx Research shows intestinal parasite infestations reduce COVID-19 severity] - Liji Thomas, News Medical)		::(Related media article: [https://www.news-medical.net/news/20210204/Research-shows-intestinal-parasite-infestations-reduce-COVID-19-severity.aspx Research shows intestinal parasite infestations reduce COVID-19 severity] - Liji Thomas, News Medical)

	* 2021 Jan [https://pubmed.ncbi.nlm.nih.gov/33153921/ Potential Influence of Helminth Molecules on COVID-19 Pathology]		* 2021 Jan [https://pubmed.ncbi.nlm.nih.gov/33153921/ Potential Influence of Helminth Molecules on COVID-19 Pathology] -- [https://www.sciencedirect.com/science/article/pii/S1471492220302804 Full text] \| [https://www.cell.com/trends/parasitology/pdf/S1471-4922(20)30280-4.pdf PDF]
			:{{Quote\|indent}}Helminth parasites could change the outcome of COVID-19 infections, in areas of the world where helminthic infections are still prevalent, by inducing a modified Th2 response with a controlled inflammatory component. Notably, in countries of Africa and Latin America, where helminth infections are still common, the numbers of reported COVID-19 deaths are substantially lower than those reported in high-income countries.{{Quote\|/indent}}

	* 2020 Oct 20 [https://~~academic~~.~~oup~~.~~com/emph/advance-article/doi/10~~.~~1093/emph~~/~~eoaa037~~/~~5930904~~ Old friends meet a new foe: A potential role for immune-priming parasites in mitigating COVID-19 morbidity and mortality] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665448/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665448/pdf/eoaa037.pdf PDF]		* 2020 Oct 20 [https://pubmed.ncbi.nlm.nih.gov/33235797/ Old friends meet a new foe: A potential role for immune-priming parasites in mitigating COVID-19 morbidity and mortality] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665448/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665448/pdf/eoaa037.pdf PDF]
	:{{Quote\|indent}}An evolutionary perspective is required to understand the global impact and various presentations of COVID-19. We consider how coinfection with soil-transmitted helminths (common parasitic worms that coevolved with humans) may suppress inflammatory immune activity, thereby potentially reducing COVID-19 disease severity.{{Quote\|/indent}}		:{{Quote\|indent}}An evolutionary perspective is required to understand the global impact and various presentations of COVID-19. We consider how coinfection with soil-transmitted helminths (common parasitic worms that coevolved with humans) may suppress inflammatory immune activity, thereby potentially reducing COVID-19 disease severity.{{Quote\|/indent}}
	::(Related media article: [https://web.archive.org/web/20220516224132/https://communique.uccs.edu/?p=128160 Cepon-Robins illustrates how immune responses to intestinal parasites could reduce severity of COVID-19] - Anna Squires, Communique.)		::(Related media article: [https://web.archive.org/web/20220516224132/https://communique.uccs.edu/?p=128160 Cepon-Robins illustrates how immune responses to intestinal parasites could reduce severity of COVID-19] - Anna Squires, Communique.)

	* 2020 Oct 15 [https://pubmed.ncbi.nlm.nih.gov/33153921/ Potential Influence of Helminth Molecules on COVID-19 Pathology] -- [https://www.sciencedirect.com/science/article/pii/S1471492220302804 Full text] \| [https://www.cell.com/trends/parasitology/pdf/S1471-4922(20)30280-4.pdf PDF]
	:{{Quote\|indent}}Helminth parasites could change the outcome of COVID-19 infections, in areas of the world where helminthic infections are still prevalent, by inducing a modified Th2 response with a controlled inflammatory component. Notably, in countries of Africa and Latin America, where helminth infections are still common, the numbers of reported COVID-19 deaths are substantially lower than those reported in high-income countries.{{Quote\|/indent}}

	* 2020 Oct 8 [https://pubmed.ncbi.nlm.nih.gov/33117371/ COVID-19 Lethality in Sub-Saharan Africa and Helminth Immune Modulation] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578247/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578247/pdf/fimmu-11-574910.pdf PDF]		* 2020 Oct 8 [https://pubmed.ncbi.nlm.nih.gov/33117371/ COVID-19 Lethality in Sub-Saharan Africa and Helminth Immune Modulation] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578247/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578247/pdf/fimmu-11-574910.pdf PDF]
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	::Explores the possible factors, including parasites, that may be contributing to the lower number of COVID-19 deaths reported in Africa.		::Explores the possible factors, including parasites, that may be contributing to the lower number of COVID-19 deaths reported in Africa.

	* 2020 May 1 [https://~~www~~.ncbi.nlm.nih.gov~~/pubmed~~/32358579 Will helminth co-infection modulate COVID-19 severity in endemic regions?] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193760/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193760/pdf/41577_2020_Article_330.pdf PDF]		* 2020 May 1 [https://pubmed.ncbi.nlm.nih.gov/32358579 Will helminth co-infection modulate COVID-19 severity in endemic regions?] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193760/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193760/pdf/41577_2020_Article_330.pdf PDF]
	:{{Quote\|indent}}We call on the research community to investigate the influence of helminth co-infection on COVID-19 outcomes as the pandemic spreads through the helminth-endemic regions of the word. Potential negative effects may influence recommendations on deworming.{{Quote\|/indent}}		:{{Quote\|indent}}We call on the research community to investigate the influence of helminth co-infection on COVID-19 outcomes as the pandemic spreads through the helminth-endemic regions of the word. Potential negative effects may influence recommendations on deworming.{{Quote\|/indent}}

← Older revision		Revision as of 16:47, 15 September 2026
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	See also		See also

			* 2026 Aug 27 https://www.jpbsci.com/index.php/jpbs/article/view/214 MicroRNA-Mediated Host–Pathogen Communication in Infectious and Parasitic Diseases: From Molecular Mechanisms to Biomarkers and Therapeutic Strategies]
	* 2026 Feb 2 [https://link.springer.com/article/10.1007/s40883-026-00563-9 Regenerating Earthworm-Derived Extracellular Vesicles Enhance Mouse Fibroblast Growth and Migration]		* 2026 Feb 2 [https://link.springer.com/article/10.1007/s40883-026-00563-9 Regenerating Earthworm-Derived Extracellular Vesicles Enhance Mouse Fibroblast Growth and Migration]
	* 2025 Dec 18 [https://pubmed.ncbi.nlm.nih.gov/41411282/ Cross-kingdom RNAi: A universal mechanism of inter-organismal communication with many unknowns] -- [https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb/eraf543/8383739?login=false Full text]		* 2025 Dec 18 [https://pubmed.ncbi.nlm.nih.gov/41411282/ Cross-kingdom RNAi: A universal mechanism of inter-organismal communication with many unknowns] -- [https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb/eraf543/8383739?login=false Full text]
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	* 2025 Jul 1 [https://pubmed.ncbi.nlm.nih.gov/40597393/ Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms]		* 2025 Jul 1 [https://pubmed.ncbi.nlm.nih.gov/40597393/ Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms]
	* 2025 Apr 29 [https://pubmed.ncbi.nlm.nih.gov/40302223/ Cytokines from parasites: manipulating host responses by molecular mimicry] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12203974/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12203974/pdf/BCJ-482-09-BCJ20253061.pdf PDF]		* 2025 Apr 29 [https://pubmed.ncbi.nlm.nih.gov/40302223/ Cytokines from parasites: manipulating host responses by molecular mimicry] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12203974/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12203974/pdf/BCJ-482-09-BCJ20253061.pdf PDF]
	* 2025 Feb 21 [https://pubmed.ncbi.nlm.nih.gov/39984487/ TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11845725/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11845725/pdf/41467_2025_Article_56954.pdf PDF~~]		* 2025 Feb 21 [https://pubmed.ncbi.nlm.nih.gov/39984487/ TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts]
	* 2025 Jan [https://pubmed.ncbi.nlm.nih.gov/39609640/ The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11723922/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11723922/pdf/44319_2024_Article_323.pdf PDF~~]		* 2025 Jan [https://pubmed.ncbi.nlm.nih.gov/39609640/ The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding]
	* 2024 Dec 28 [https://pubmed.ncbi.nlm.nih.gov/39732815/ Molecular and biological characterization of transforming growth factor-β homolog derived from Trichinella spiralis] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11682454/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11682454/ PDF]		* 2024 Dec 28 [https://pubmed.ncbi.nlm.nih.gov/39732815/ Molecular and biological characterization of transforming growth factor-β homolog derived from Trichinella spiralis] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11682454/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11682454/ PDF]
	* 2024 Sep 5 [https://helminthconference.org/wp-content/uploads/2024/08/Abstracts-Day-4-Thursday-05-09-2024.pdf The H. polygyrus TGF-β mimic TGM1 exerts broad anti-inflammatory effects on multiple immune cell types] (Conference)		* 2024 Sep 5 [https://helminthconference.org/wp-content/uploads/2024/08/Abstracts-Day-4-Thursday-05-09-2024.pdf The H. polygyrus TGF-β mimic TGM1 exerts broad anti-inflammatory effects on multiple immune cell types] (Conference)
	* 2024 Sep 5 [https://helminthconference.org/wp-content/uploads/2024/08/Abstracts-Day-4-Thursday-05-09-2024.pdf Modular H. polygyrus TGF-β mimic proteins molecularly mimic mammalian TGF-β, enabling effective immune-modulation, while limiting fibrogenesis] (Conference)		* 2024 Sep 5 [https://helminthconference.org/wp-content/uploads/2024/08/Abstracts-Day-4-Thursday-05-09-2024.pdf Modular H. polygyrus TGF-β mimic proteins molecularly mimic mammalian TGF-β, enabling effective immune-modulation, while limiting fibrogenesis] (Conference)
	* 2024 Aug 23 [https://pubmed.ncbi.nlm.nih.gov/39179288/ Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration] (Also reported by Advanced Science News. [https://www.advancedsciencenews.com/molecules-secreted-by-parasitic-worms-found-to-reduce-scarring-during-wound-healing/]) (Wound healing)		* 2024 Aug 23 [https://pubmed.ncbi.nlm.nih.gov/39179288/ Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration] (Also reported by Advanced Science News. [https://www.advancedsciencenews.com/molecules-secreted-by-parasitic-worms-found-to-reduce-scarring-during-wound-healing/]) (Wound healing)
	* 2024 Apr [https://pubmed.ncbi.nlm.nih.gov/37832870/ Exogenous Transforming Growth Factor-β1 and Its Helminth-Derived Mimic Attenuate the Heart's Inflammatory Response to Ischemic Injury and Reduce Mature Scar Size~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12178337/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12178337/pdf/main.pdf PDF~~]		* 2024 Apr [https://pubmed.ncbi.nlm.nih.gov/37832870/ Exogenous Transforming Growth Factor-β1 and Its Helminth-Derived Mimic Attenuate the Heart's Inflammatory Response to Ischemic Injury and Reduce Mature Scar Size]
	* 2023 Nov 15 [https://pubmed.ncbi.nlm.nih.gov/38014296/ The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC10680678/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC10680678/pdf/nihpp-2023.11.13.566701v1.pdf PDF~~] (Preprint)		* 2023 Nov 15 [https://pubmed.ncbi.nlm.nih.gov/38014296/ The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells] (Preprint)
	* 2023 Sep 4 [https://pubmed.ncbi.nlm.nih.gov/37625791/ Convergent Evolution in a Murine Intestinal Parasite Rapidly Created the TGM Family of Molecular Mimics to Suppress the Host Immune Response] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC10516467/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC10516467/pdf/evad158.pdf PDF]		* 2023 Sep 4 [https://pubmed.ncbi.nlm.nih.gov/37625791/ Convergent Evolution in a Murine Intestinal Parasite Rapidly Created the TGM Family of Molecular Mimics to Suppress the Host Immune Response] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC10516467/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC10516467/pdf/evad158.pdf PDF]
	* 2023 Aug 22 [https://pubmed.ncbi.nlm.nih.gov/37590410/ CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC10450677/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC10450677/pdf/pnas.202302370.pdf PDF~~]		* 2023 Aug 22 [https://pubmed.ncbi.nlm.nih.gov/37590410/ CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic]
	* 2023 Jan 18 [https://pubmed.ncbi.nlm.nih.gov/36855464/ Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, Hp-TGM~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC9958376/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC9958376/ PDF~~]		* 2023 Jan 18 [https://pubmed.ncbi.nlm.nih.gov/36855464/ Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, Hp-TGM]
	* 2022 Oct 4 [https://pubmed.ncbi.nlm.nih.gov/36194274/ Identification and expression of a transforming growth factor beta (TGF-β) homologue in the tropical liver fluke Fasciola gigantica] -- [https://link.springer.com/article/10.1007/s00436-022-07679-1 Full text]		* 2022 Oct 4 [https://pubmed.ncbi.nlm.nih.gov/36194274/ Identification and expression of a transforming growth factor beta (TGF-β) homologue in the tropical liver fluke Fasciola gigantica] -- [https://link.springer.com/article/10.1007/s00436-022-07679-1 Full text]
	* 2022 Oct [https://pubmed.ncbi.nlm.nih.gov/35758054/ Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC9885513/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC9885513/pdf/IMM-167-197.pdf PDF~~]		* 2022 Oct [https://pubmed.ncbi.nlm.nih.gov/35758054/ Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β]
	* 2022 Jun 27 [https://pubmed.ncbi.nlm.nih.gov/35758054/ Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β]		* 2022 Jun 27 [https://pubmed.ncbi.nlm.nih.gov/35758054/ Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β]
	* 2022 Jun [https://pubmed.ncbi.nlm.nih.gov/35500648/ Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII]		* 2022 Jun [https://pubmed.ncbi.nlm.nih.gov/35500648/ Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII]
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	* 2021 Nov 10 [https://pubmed.ncbi.nlm.nih.gov/34390759/ Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8516079/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8516079/pdf/main.pdf PDF]		* 2021 Nov 10 [https://pubmed.ncbi.nlm.nih.gov/34390759/ Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8516079/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8516079/pdf/main.pdf PDF]
	* 2021 Nov [https://www.myeventflo.com/brochures/Poster0023378.pdf Targeted Identification of New Parasite Immunomodulators Against Allergic Asthma] (Poster)		* 2021 Nov [https://www.myeventflo.com/brochures/Poster0023378.pdf Targeted Identification of New Parasite Immunomodulators Against Allergic Asthma] (Poster)
	* 2021 Sep [https://pubmed.ncbi.nlm.nih.gov/33929751/ Induction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC8453874/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC8453874/pdf/IMCB-99-833.pdf PDF~~]		* 2021 Sep [https://pubmed.ncbi.nlm.nih.gov/33929751/ Induction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic]
	* 2021 Sep [https://pubmed.ncbi.nlm.nih.gov/33988885/ The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC9214624/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC9214624/pdf/IMCB-99-848.pdf PDF~~]		* 2021 Sep [https://pubmed.ncbi.nlm.nih.gov/33988885/ The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells]
	* 2020 Jun 26 [https://pubmed.ncbi.nlm.nih.gov/32586367/ A daf-7-related TGF-β ligand (Hc-tgh-2) shows important regulations on the development of Haemonchus contortus]		* 2020 Jun 26 [https://pubmed.ncbi.nlm.nih.gov/32586367/ A daf-7-related TGF-β ligand (Hc-tgh-2) shows important regulations on the development of Haemonchus contortus]
	* 2020 May 8 [https://pubmed.ncbi.nlm.nih.gov/32457746/ Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC7225322/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC7225322/pdf/fimmu-11-00798.pdf PDF~~]		* 2020 May 8 [https://pubmed.ncbi.nlm.nih.gov/32457746/ Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis]
	* 2019 Nov [https://eprints.nottingham.ac.uk/60409/?template=etheses The Fasciola hepatica growth factor; FhTLM, and actions in immune evasion and parasite survival] (Thesis)		* 2019 Nov [https://eprints.nottingham.ac.uk/60409/?template=etheses The Fasciola hepatica growth factor; FhTLM, and actions in immune evasion and parasite survival] (Thesis)
	* 2018 Dec [https://pubmed.ncbi.nlm.nih.gov/30317150/ Fasciola hepatica, TGF-β and host mimicry: the enemy within]		* 2018 Dec [https://pubmed.ncbi.nlm.nih.gov/30317150/ Fasciola hepatica, TGF-β and host mimicry: the enemy within]
	* 2018 Sep 4 [https://helminthconference.org/wp-content/uploads/2023/05/2018-Hydra-Conference-Booklet.pdf Structure-function studies of the H. polygyrus TGF-β mimic TGM] (Conference)		* 2018 Sep 4 [https://helminthconference.org/wp-content/uploads/2023/05/2018-Hydra-Conference-Booklet.pdf Structure-function studies of the H. polygyrus TGF-β mimic TGM] (Conference)
	* 2018 Apr [https://pubmed.ncbi.nlm.nih.gov/29510118/ TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC5904571/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC5904571/pdf/main.pdf PDF~~]		* 2018 Apr [https://pubmed.ncbi.nlm.nih.gov/29510118/ TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus]
	* 2017 Nov 23 [https://pubmed.ncbi.nlm.nih.gov/29170498 A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells~~] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701006/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701006/pdf/41467_2017_Article_1886.pdf PDF~~]		* 2017 Nov 23 [https://pubmed.ncbi.nlm.nih.gov/29170498 A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells]
	* 2016 Nov 2 [https://pubmed.ncbi.nlm.nih.gov/27806135/ A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes~~] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC5091765/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC5091765/pdf/ppat.1005991.pdf PDF~~]		* 2016 Nov 2 [https://pubmed.ncbi.nlm.nih.gov/27806135/ A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes]
	* 2016 Sep 14 [https://onlinelibrary.wiley.com/doi/full/10.1111/imj.53_13197 The immunomodulatory role of helminth protein Bm TGH-2 in atopic disease – an in vitro pilot study] (Conference)		* 2016 Sep 14 [https://onlinelibrary.wiley.com/doi/full/10.1111/imj.53_13197 The immunomodulatory role of helminth protein Bm TGH-2 in atopic disease – an in vitro pilot study] (Conference)