Helminthic therapy and C-reactive protein (CRP)

CRP usually rises following the first inoculation with helminths, before eventually reducing to a more normal level.

In the case of NA, there is a transient rise in CRP between days 20–34, i.e., during the late larval migration and early establishment of the pre-adult worms in the intestine. Then the CRP should drop to baseline within 4 months. Following repeat inoculations, any rise in CRP should be less pronounced, if there is a rise at all.

A subject using NA to treat Mixed Connective Tissue Disease/Lupus reported that her CRP fell from 2.20 to 0.50 (Standard Range: 0.02 - 0.5 mg/dL). [1]

Following administration of TSO, serum hs-CRP rose (along with blood eosinophils) during the first two months, and then fell in most subjects during and after the last month of ova exposure. [2]

A lady with Crohn's, lupus and coeliac disease, who had become infected with the helminth, Enterobius vermicularis, has reported that her rheumatologist apparently had difficulty believing his eyes when her test results showed that her CRP was near normal! [3]

Someone treating Crohn’s disease, who had seen their CRP fall from 60 to 48 while using LDN, saw a further reduction to 12.5 after 5 months with TTO. (Normal CRP in the US is under 3.0) [4]

Long-term hosting of helminths should keep CRP well controlled, and one subject reported that their CRP was "low" after hosting hookworm for 2 years.

A subject with Crohn's who lost her hookworms reported that, once they were gone, her CRP rose again.

While CRP is an inflammation marker, it is not a reliable indicator of inflammation, especially in chronic inflammatory disorders, as can be seen from this support group discussion. [5]