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Human helminth care manual: Difference between revisions
→Miscellaneous pharmaceuticals and chemicals
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* [https://en.wikipedia.org/wiki/Cromoglicic_acid Cromoglicic acid] (cromolyn, cromoglycate or cromoglicate, sodium cromoglicate [Nalcrom] or cromolyn sodium)<br>is a mast cell stabiliser with anti-allergy effects. One hookworm host has taken 8x100mg capsules of Nalcrom daily for periods of up to 10 days without any adverse effect on her colony. [https://www.facebook.com/groups/htsupport/permalink/952539741468648/?comment_id=953466358042653&comment_tracking=%7B%22tn%22:%22R1%22%7D] | * [https://en.wikipedia.org/wiki/Cromoglicic_acid Cromoglicic acid] (cromolyn, cromoglycate or cromoglicate, sodium cromoglicate [Nalcrom] or cromolyn sodium)<br>is a mast cell stabiliser with anti-allergy effects. One hookworm host has taken 8x100mg capsules of Nalcrom daily for periods of up to 10 days without any adverse effect on her colony. [https://www.facebook.com/groups/htsupport/permalink/952539741468648/?comment_id=953466358042653&comment_tracking=%7B%22tn%22:%22R1%22%7D] | ||
* ❌ [http://en.wikipedia.org/wiki/Cry5B Cry5B]. This is one of a family of proteins produced by [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis] (Bt), a bacterium that has been engineered into food crops such as corn and rice to render them pest resistant, and residues of B. thuringiensisbased insecticides have been found on fresh fruits and vegetables. [http://www.ncbi.nlm.nih.gov/pubmed/16672488] Cry5B can kill intestinal worms and is used as a natural insecticide on crops on some organic farms. The probiotic bacterium, Bacillus subtilis, can also be engineered to express the Cry5B protein, a small dose of which has been shown to kill intestinal nematode parasites, achieving a 93 percent elimination of human hookworms in hamsters. [https://www.asm.org/index.php/asm-newsroom2/journal-tipsheets/88-news-room/journal-tipsheets/91749-natural-pest-control-protein-effective-against-hookworm-a-billion-could-benefit], [http://www.ncbi.nlm.nih.gov/pubmed/23835175] Although researchers may be pursuing this development as a means of delivering anthelminthics via foods and food supplements, the strain of Bacillus subtilis currently used in probiotics that have been manufactured for human consumption is not known to have been modified in this way, and one hookworm host has reported that his worms were unaffected after eating a lot of natto (made using Bacillus subtilis) and taking the Bacillus subtilis-containing probiotic product, Megasporebiotic. [https://www.facebook.com/groups/htsupport/permalink/1084149894974298/?comment_id=1084177824971505&comment_tracking=%7B%22tn%22:%22R6%22%7D] | * ❌ [http://en.wikipedia.org/wiki/Cry5B Cry5B]. This is one of a family of proteins produced by [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis] (Bt), a bacterium that has been engineered into food crops such as corn and rice to render them pest resistant, and residues of B. thuringiensisbased insecticides have been found on fresh fruits and vegetables. [http://www.ncbi.nlm.nih.gov/pubmed/16672488] Cry5B can kill intestinal worms and is used as a natural insecticide on crops on some organic farms. However, it is thought that the risk of therapeutic helminths being killed as a result of their hosts ingesting small amounts of the delta endotoxins produced by Bt is likely to be very low. When used as an insecticide, one of the many Bt strains available is selected for its specific toxicity against the target insect. The strains that produce toxins against nematodes are therefore unlikely to be used as agricultural insecticides. In addition to this, the toxins produced need to be ingested by the target organism to become active and, as proteins, they may be denatured by heat during cooking. The probiotic bacterium, Bacillus subtilis, can also be engineered to express the Cry5B protein, a small dose of which has been shown to kill intestinal nematode parasites, achieving a 93 percent elimination of human hookworms in hamsters. [https://www.asm.org/index.php/asm-newsroom2/journal-tipsheets/88-news-room/journal-tipsheets/91749-natural-pest-control-protein-effective-against-hookworm-a-billion-could-benefit], [http://www.ncbi.nlm.nih.gov/pubmed/23835175] Although researchers may be pursuing this development as a means of delivering anthelminthics via foods and food supplements, the strain of Bacillus subtilis currently used in probiotics that have been manufactured for human consumption is not known to have been modified in this way, and one hookworm host has reported that his worms were unaffected after eating a lot of natto (made using Bacillus subtilis) and taking the Bacillus subtilis-containing probiotic product, Megasporebiotic. [https://www.facebook.com/groups/htsupport/permalink/1084149894974298/?comment_id=1084177824971505&comment_tracking=%7B%22tn%22:%22R6%22%7D] | ||
* ❓ [https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid DMPS] (Dimercapto-propane sulfonate/2,3-Dimercapto-1-propanesulfonic acid) and its sodium salt, Unithiol. There have been no reports so far about possible anthelminthic effects following the use of this drug, but there do appear to be some [https://www.ncbi.nlm.nih.gov/pubmed/18568806 serious risks attached to its use]. | * ❓ [https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid DMPS] (Dimercapto-propane sulfonate/2,3-Dimercapto-1-propanesulfonic acid) and its sodium salt, Unithiol. There have been no reports so far about possible anthelminthic effects following the use of this drug, but there do appear to be some [https://www.ncbi.nlm.nih.gov/pubmed/18568806 serious risks attached to its use]. | ||