Helminth therapy studies in murine models

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    This page is still under construction. Please see Helminthic therapy research.

    Also see Helminthic therapy clinical trials.

    Murine studies by disease[edit | edit source]

    Allergy and asthma[edit | edit source]

    Atherosclerosis[edit | edit source]

    Bronchiolitis by Respiratory syncytial virus (RSV)[edit | edit source]

    Diabetes type 1[edit | edit source]

    Diabetes type 2[edit | edit source]

    Dyslipidemia[edit | edit source]

    Eczema / Dermatitis[edit | edit source]

    Cancer[edit | edit source]

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    Together, these findings show that helminth infection can protect against distal viral infection and suppress the growth and cancer cell behaviour of HPV associated cervical cancer
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    No effect of the helminth H. diminuta was observed. (N.B. The same experiment needs to be done with Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri.)

    Negative effects of helminths

    Crohn's[edit | edit source]

    Influenza[edit | edit source]

    Multiple Sclerosis[edit | edit source]

    Myocardial infarction[edit | edit source]

    Neuroprotection[edit | edit source]

    Obesity[edit | edit source]

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    Collectively, these observations demonstrate that helminth infections alter the structure of duodenal lacteals and compromise duodenal lymphatic lipid uptake, leading to lipid accumulation in epithelial cells and, under high-fat diet conditions, decreased weight gain.

    Psoriasis[edit | edit source]

    Rheumatoid arthritis[edit | edit source]

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    N. brasiliensis infection suppresses inflammatory arthritis.

    Salmonella[edit | edit source]

    Sepsis[edit | edit source]

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    Treatment with recombinant Nb-SPI-I8 significantly increased the probability of survival of mice from lethal sepsis.

    Ulcerative Colitis[edit | edit source]

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    ... administration of recombinant N. brasiliensis SPI-I8 significantly reduced the impact of colitis on colon length, with no side effects detected.

    Others studies[edit | edit source]

    Negative effects[edit | edit source]

    Therapeutic helminth counterparts for murine models[edit | edit source]

    This table shows the therapeutic helminths that correspond with each murine model helminth.

    Murine models    Therapeutic helminths   
    Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri [2] Necator Americanus
    Trichuris muris Trichuris trichiura, Trichuris suis
    Hymenolepis diminuta Hymenolepis diminuta

    Nippostrongylus brasiliensis have a similar cycle than Necator Americanus. It is a rat helminth, which is also used on mouse models but does not survive. Heligmosomoides polygyrus bakeri has a shorter cycle that is adapted to mice. Studies with these two model species complement each other.

    Methodology[edit | edit source]

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    Trichuris muris, depending on the infectious dose, can generate either chronic persistent infections, characterized by a Th1 response and the production of the cytokine interferon (IFN)-γ (low dose infection with ∼25 eggs), or acute infections cleared by a strong Th2 response with the production of interleukin (IL)-5, IL-9, and IL-13 in response to high amounts of eggs (∼150 eggs).[3],[4],[5]:

    The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    a change which is a result or consequence of an action or other cause.

    A murine (rat) tapeworm used in helminthic therapy that generally does not mature in humans and is taken as cysticerci (HDC) in a drink every 2 or 3 weeks.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    Hymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta

    The human whipworm used in helminthic therapy and taken periodically as microscopic eggs (TTO) in a drink.

    The porcine (pig) whipworm used in helminthic therapy and taken as microscopic eggs (TSO) in a drink every two weeks.

    A murine (rat) tapeworm used in helminthic therapy that generally does not mature in humans and is taken as cysticerci (HDC) in a drink every 2 or 3 weeks.

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