Helminth therapy studies in murine models
This page is still under construction.
Also see Helminthic therapy clinical trials.
Murine studies by disease[edit | edit source]
Diabetes type 1[edit | edit source]
- 2017 Nov 8 Taenia crassiceps Antigens Control Experimental Type 1 Diabetes by Inducing Alternatively Activated Macrophages — Full text | PDF
- 2010 Jan 4 Taenia crassiceps infection attenuates multiple low-dose streptozotocin-induced diabetes -- Full text | PDF
Multiple Sclerosis[edit | edit source]
Myocardial infarction[edit | edit source]
- 2025 Jun 5 PD-1-dependent therapeutic effect of Trichinella spiralis cystatin on myocardial infarction in a mice model -- Full text (Study to be done again with therapeutic helminths)
Obesity[edit | edit source]
- 2025 Jun 12 Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection -- Full text | PDF "Collectively, these observations demonstrate that helminth infections alter the structure of duodenal lacteals and compromise duodenal lymphatic lipid uptake, leading to lipid accumulation in epithelial cells and, under high-fat diet conditions, decreased weight gain".
Sepsis[edit | edit source]
- 2025 Mar 3 Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1 -- Full text | PDF. "Treatment with recombinant Nb-SPI-I8 significantly increased the probability of survival of mice from lethal sepsis."
Ulcerative Colitis[edit | edit source]
- 2025 Jun 27 Intact glycoconjugates from Taenia crassiceps excreted/secreted products ameliorate chemically induced colitis by modulating inflammation and strengthening adherens junctions -- Full text
- 2025 Mar 3 Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1 -- Full text | PDF. "administration of recombinant N. brasiliensis SPI-I8 significantly reduced the impact of colitis on colon length, with no side effects detected."
Counterpart murine models vs human helminths[edit | edit source]
- Necator Americanus: Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri [1].
- Trichuris Trichura: Trichuris Muris