Helminthic therapy may help in treating Lyme disease and its consequences
Effect on the disease itself
The following report is from the doctor of a patient (also a physician) with Lyme disease who infected herself with hookworms and has declared herself cured as a result.
Overall effect on living with Lyme
Possible effect on Post-treatment Lyme disease syndrome (PTLDS)
Ten percent of patients whose Lyme disease has been successfully treated with antibiotics go on to develop Post-treatment Lyme disease syndrome (PTLDS) which has been linked with widespread brain inflammation.  Helminthic therapy may provide a safe option for treating this inflammation.
Considerations when using helminths in patients with Lyme disease
There are two problems for anyone with Lyme disease who is considering the use of helminthic therapy.
Firstly, a chronic infection such as HIV, hepatitis, herpes or Lyme disease might actually be made worse as a result of hosting helminths, especially in the early stages after the initial inoculation. (See Helminthic therapy and chronic infections.) For this reason, some helminth providers may be reluctant to supply worms to someone with this disease, although this will depend on the details of each individual case.
Secondly, the treatment of Lyme disease has traditionally involved prolonged antibiotic use. While these drugs would generally not present a problem for users of the two non-human helminths, TSO and HDC, they would render human helminths ineffective. Therefore, if someone with Lyme disease were intent on using NA or TTO, they would need to treat the disease before starting helminthic therapy. However, there are alternatives to the use of antibiotics in the treatment of Lyme disease.
While some alternatives to antibiotics can also be harmful to helminths (see Helminth care), others are not. For example, whole leaf stevia extract is harmless to helminths yet has been shown in test tube studies to be effective against all known morphological forms of the Lyme pathogen and its biofilms, and performed better than antibiotics.
- Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro -- Full text | PDF
Essential oils have also proved to be very effective against the persister stage of Lyme disease, and one study has identified several essential oils that have strong activity against the persisters. The most active of these is garlic, which completely eradicated the dormant persisters that were not killed by the current Lyme antibiotics, and they did so, with no regrowth, at only 0.05%.
- Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi -- Full text | PDF
While antibiotics generally have no adverse effect on the non-human helminth, TSO, it is possible that Ciprofloxacin might "slow down" this species somewhat, although the drug shouldn't completely inhibit it. )