Helminthic therapy and gluten-related disorders

    From Helminthic Therapy wiki

    Home>Effects of helminthic therapy>Helminthic therapy and gluten-related disorders

    The term, gluten-related disorders, covers several diseases triggered by gluten, including coeliac disease / celiac disease (CD), non-coeliac gluten sensitivity / non-celiac gluten sensitivity (NCGS), non-coeliac wheat sensitivity, non-celiac wheat sensitivity (NCWS), gluten ataxia, dermatitis herpetiformis (DH) and wheat allergy.

    Coeliac / celiac disease

    Coeliac disease (celiac disease in American English) is a long-term autoimmune disorder, primarily affecting the small intestine, in which individuals develop intolerance to gluten present in foods such as wheat, rye and barley. [1]

    This disease can be helped, at least to some extent, by hosting helminths. For example, the presence of helminths can significantly reduce the severity of adverse reactions caused by accidental exposure to gluten while following a gluten-free diet.

    The scientific evidence

    NB. In spite of their double-blind, placebo-controlled design, some “gold standard” helminthic therapy trials may have produced unreliable results due to a lack of adequate consideration of the biology of living helminths and their interactions with their hosts. [2] For more about this, see: Problems with clinical trials using live helminths.

    The anecdotal evidence

    Non-coeliac / celiac gluten sensitivity (NCGS)

    Non-celiac gluten sensitivity (NCGS) or gluten sensitivity [5] is "a clinical entity induced by the ingestion of gluten leading to intestinal and/or extraintestinal symptoms that improve once the gluten-containing foodstuff is removed from the diet, and celiac disease and wheat allergy have been excluded". [6]

    NCGS can respond well to helminthic therapy.

    The anecdotal evidence

    Gluten ataxia

    Gluten ataxia is an autoimmune disease triggered by the ingestion of gluten. [7][8]

    The anecdotal evidence

    Dermatitis herpetiformis (DH)

    Dermatitis herpetiformis is an autoimmune skin condition related to coeliac disease that manifests in chronic blistering of the skin. This condition is not related to herpes, but was given its name because the skin inflammation that it causes has a similar appearance to herpes.

    The anecdotal evidence

    See also

    A useful adjunctive measure to reduce adverse reactions to accidental gluten exposure - the Aspergillus niger‐derived prolyl endoprotease (AN‐PEP).