Helminthic therapy and graft-versus-host disease (GVHD)

⚭Home>Effects of helminthic therapy>Helminthic therapy and graft-versus-host disease (GVHD)

Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants.

The scientific evidence

• 2024 Dec 31 The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect -- Full text | PDF

• 2023 Jun 9 After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease -- Full text | PDF

• 2019 Mar Intestinal Immune Conditioning with Helminths Employs Host T Helper 2 (Th2) Pathway to Induce Mixed Chimerism and Regulate Graft-Versus-Host Disease -- PDF

• 2018 Oct 5 Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells -- Full text | PDF

• 2015 Feb 1 Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versustumor effect in mice -- Full text | PDF (Helminths improve the outcome of bone marrow transplantation in mice)

• 2010 May Helminths Regulate Acute Graft Versus Host Disease and Colitis in a TGFβ Dependent Manner in Mice

See also

• 2021 Oct 5 T Cell Subsets in Graft Versus Host Disease and Graft Versus Tumor -- Full text | PDF
• 2021 Aug 27 Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage -- Full text | PDF

• Helminthic therapy and organ transplantation
• Helminthic therapy and cancer

• Fecal microbiota transplantation to prevent graft-versus-host disease

The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

The specific population of microorganisms living in a certain part of the body, such as the gut. "Microbiome" refers to all the microorganisms living in and on the body, or the genome of these microorganisms. These two terms are often used interchangeably.