Helminthic therapy and graft-versus-host disease (GVHD)

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Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants.

The scientific evidence

• 2024 Dec 31 The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect -- Full text | PDF

• 2023 Jun 9 After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease -- Full text | PDF

• 2019 Mar Intestinal Immune Conditioning with Helminths Employs Host T Helper 2 (Th2) Pathway to Induce Mixed Chimerism and Regulate Graft-Versus-Host Disease -- PDF

• 2018 Oct 5 Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells -- Full text | PDF

• 2015 Feb 1 Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versustumor effect in mice -- Full text | PDF (Helminths improve the outcome of bone marrow transplantation in mice)

See also

• 2021 Aug 27 Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage -- Full text | PDF

• Helminthic therapy and organ transplantation

The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths