Mechanisms underlying helminth colonization
(Redirected from Mechanisms underlying helminth infection)
This page aims to describe the different mecanisms underlying helminth colonization.
Percutaneous penetration[edit | edit source]
- 2025 Acquired resistance against penetration by strongylodies ratti is mediated by IL-33-dependent induction of gamma delta T cells -- PDF (thesis) (May not be not relevant to therapeutic helminths.)
Tissue-protective response[edit | edit source]
- 2025 Jun 12 A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection -- Full text
- 2018 Sep 20 Host–Parasite Interactions Promote Disease Tolerance to Intestinal Helminth Infection -- Full text | PDF
Lung Effect[edit | edit source]
- 2025 Jun 19 Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair -- Full text
- 2025 May 8 Macrophage-Derived Relmα Promotes Lung Tissue Repair Following Helminth Infection In a Murine Model (capstone project)
- 2023 Oct 13 Myeloid- and epithelial-derived RELMα contribute to tissue repair following lung helminth infection -- Full text | PDF
- 2019 Dec 2 ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites -- Full text | PDF
Wound Healing[edit | edit source]
- 2023 Feb 13 Helminth egg derivatives as proregenerative immunotherapies -- Full text | PDF (improved repair and decreased fibrosis). "These immunotherapies have the potential to promote wound healing and inhibit fibrosis across multiple tissues and injury types."
Microbiota change[edit | edit source]
- 2020 Jul 3 Helminth-induced and Th2-dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High Fat Diet -- Full text | PDF
- 2020 Feb 20 Whipworm Infection Promotes Bacterial Invasion, Intestinal Microbiota Imbalance, and Cellular Immunomodulation -- Full text | PDF
Effect on lipid metabolism[edit | edit source]
- 2025 Jun 12 Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection -- Full text | PDF
Collectively, these observations demonstrate that helminth infections alter the structure of duodenal lacteals and compromise duodenal lymphatic lipid uptake, leading to lipid accumulation in epithelial cells and, under high fat diet conditions, decreased weight gain.
- 2025 Intestinal helminth Schyzocotyle acheilognathi Yamaguti, 1934 infection ameliorate lipid metabolism of grass carp (Ctenopharyngodon idella) through immune and gut microbiota regulation (May not be not relevant to therapeutic helminths.)
- 2020 Jul 3 Helminth-induced and Th2-dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High Fat Diet -- Full text | PDF
Activation of group 2 innate lymphoid cells (ILC2s)[edit | edit source]
- 2025 Jun 12 Gut ILC2s remember IL-25
Restraint of TVM cell expansion[edit | edit source]
- 2025 Feb 7 IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells (Also reported by ScienceDaily [1])
CD4+ Th2 responses[edit | edit source]
- 2025 Jul 10 Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection -- Full text
- 2017 Jan Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4+ Th2 responses and promote chronic infection -- Full text
Excretory secretions[edit | edit source]
MicroRNA[edit | edit source]
- 2025 Mar 27 A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity -- Full text | PDF
Gastrointestinal nematodes exploit a host miRNA regulatory network to suppress host innate responses, promote tissue regeneration and establish a favourable environment for chronic infection