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Human helminth care manual: Difference between revisions
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* ❌ [http://en.wikipedia.org/wiki/Cry5B Cry5B]. This is one of a family of proteins produced by [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis] (Bt), a bacterium that has been engineered into food crops such as corn and rice to render them pest resistant, and residues of B. thuringiensisbased insecticides have been found on fresh fruits and vegetables. [http://www.ncbi.nlm.nih.gov/pubmed/16672488] Cry5B can kill intestinal worms and is used as a natural insecticide on crops on some organic farms. The probiotic bacterium, Bacillus subtilis, can also be engineered to express the Cry5B protein, a small dose of which has been shown to kill intestinal nematode parasites, achieving a 93 percent elimination of human hookworms in hamsters. [https://www.asm.org/index.php/asm-newsroom2/journal-tipsheets/88-news-room/journal-tipsheets/91749-natural-pest-control-protein-effective-against-hookworm-a-billion-could-benefit], [http://www.ncbi.nlm.nih.gov/pubmed/23835175] Although researchers may be pursuing this development as a means of delivering anthelminthics via foods and food supplements, the strain of Bacillus subtilis currently used in probiotics that have been manufactured for human consumption is not known to have been modified in this way, and one hookworm host has reported that his worms were unaffected after eating a lot of natto (made using Bacillus subtilis) and taking the Bacillus subtilis-containing probiotic product, Megasporebiotic. [https://www.facebook.com/groups/htsupport/permalink/1084149894974298/?comment_id=1084177824971505&comment_tracking=%7B%22tn%22:%22R6%22%7D] | * ❌ [http://en.wikipedia.org/wiki/Cry5B Cry5B]. This is one of a family of proteins produced by [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis] (Bt), a bacterium that has been engineered into food crops such as corn and rice to render them pest resistant, and residues of B. thuringiensisbased insecticides have been found on fresh fruits and vegetables. [http://www.ncbi.nlm.nih.gov/pubmed/16672488] Cry5B can kill intestinal worms and is used as a natural insecticide on crops on some organic farms. The probiotic bacterium, Bacillus subtilis, can also be engineered to express the Cry5B protein, a small dose of which has been shown to kill intestinal nematode parasites, achieving a 93 percent elimination of human hookworms in hamsters. [https://www.asm.org/index.php/asm-newsroom2/journal-tipsheets/88-news-room/journal-tipsheets/91749-natural-pest-control-protein-effective-against-hookworm-a-billion-could-benefit], [http://www.ncbi.nlm.nih.gov/pubmed/23835175] Although researchers may be pursuing this development as a means of delivering anthelminthics via foods and food supplements, the strain of Bacillus subtilis currently used in probiotics that have been manufactured for human consumption is not known to have been modified in this way, and one hookworm host has reported that his worms were unaffected after eating a lot of natto (made using Bacillus subtilis) and taking the Bacillus subtilis-containing probiotic product, Megasporebiotic. [https://www.facebook.com/groups/htsupport/permalink/1084149894974298/?comment_id=1084177824971505&comment_tracking=%7B%22tn%22:%22R6%22%7D] | ||
* ❓ [https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid DMPS] (Dimercapto-propane sulfonate/2,3-Dimercapto-1-propanesulfonic acid) and its sodium salt, Unithiol. There have been no reports so far about possible anthelminthic effects following the use of this drug, but there do appear to be some serious risks attached to its use. | * ❓ [https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid DMPS] (Dimercapto-propane sulfonate/2,3-Dimercapto-1-propanesulfonic acid) and its sodium salt, Unithiol. There have been no reports so far about possible anthelminthic effects following the use of this drug, but there do appear to be some [https://www.ncbi.nlm.nih.gov/pubmed/18568806 serious risks attached to its use]. | ||
* [https://en.wikipedia.org/wiki/Dimercaptosuccinic_acid DMSA] (Dimercaptosuccinic acid, also called succimer). The meso isomer form of this organosulfur compound is used as a chelating agent for the treatment of heavy metal toxicity. One hookworm host has taken 25 mg DMSA every 3 hours around the clock for 5 days, and repeated this every 3 weeks for a year without harming her hookworm colony. [https://www.facebook.com/groups/htsupport/permalink/860154964040460/?comment_id=991229547599667&comment_tracking=%7B%22tn%22:%22R0%22%7D] DMSA is apparently such an effective chelator that it may deplete levels of beneficial minerals, so should arguably be used under the guidance of a practitioner. [https://www.facebook.com/groups/htsupport/permalink/860154964040460/?comment_id=860226537366636&comment_tracking=%7B%22tn%22:%22R1%22%7D] | * [https://en.wikipedia.org/wiki/Dimercaptosuccinic_acid DMSA] (Dimercaptosuccinic acid, also called succimer). The meso isomer form of this organosulfur compound is used as a chelating agent for the treatment of heavy metal toxicity. One hookworm host has taken 25 mg DMSA every 3 hours around the clock for 5 days, and repeated this every 3 weeks for a year without harming her hookworm colony. [https://www.facebook.com/groups/htsupport/permalink/860154964040460/?comment_id=991229547599667&comment_tracking=%7B%22tn%22:%22R0%22%7D] DMSA is apparently such an effective chelator that it may deplete levels of beneficial minerals, so should arguably be used under the guidance of a practitioner. [https://www.facebook.com/groups/htsupport/permalink/860154964040460/?comment_id=860226537366636&comment_tracking=%7B%22tn%22:%22R1%22%7D] | ||
* [http://en.wikipedia.org/wiki/Dimethyl_sulfoxide DMSO] (Dimethyl sulfoxide) has been used by one helminth host without adverse effect. | * [http://en.wikipedia.org/wiki/Dimethyl_sulfoxide DMSO] (Dimethyl sulfoxide) has been [https://groups.yahoo.com/neo/groups/helminthictherapy/conversations/messages/5762 used by one helminth host] without adverse effect. | ||
* ❓ [https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid EDTA] (Ethylenediaminetetraacetic acid). There are, as yet, no reports from helminth hosts about the possible effects on intestinal worms of this heavy metal chelator. | * ❓ [https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid EDTA] (Ethylenediaminetetraacetic acid). There are, as yet, no reports from helminth hosts about the possible effects on intestinal worms of this heavy metal chelator. | ||
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* ⚡ [http://en.wikipedia.org/wiki/Piracetam Piracetam]. This nootropic, cognition- and memory-enhancing drug (Nootropil, Qropi, Myocalm, Dinagen) was suspected as the cause in one case of sudden worm loss. | * ⚡ [http://en.wikipedia.org/wiki/Piracetam Piracetam]. This nootropic, cognition- and memory-enhancing drug (Nootropil, Qropi, Myocalm, Dinagen) was suspected as the cause in one case of sudden worm loss. | ||
* [http://en.wikipedia.org/wiki/Proton-pump_inhibitor Proton-pump inhibitors] (PPIs | * [http://en.wikipedia.org/wiki/Proton-pump_inhibitor Proton-pump inhibitors] (PPIs). These gastric acid inhibiting drugs appear to be safe for use with helminths. | ||
** [https://en.wikipedia.org/wiki/Omeprazole omeprazole] (e.g., Losec) | |||
** and [https://en.wikipedia.org/wiki/Lansoprazole lansoprazole] (e.g., Prevacid). \ | |||
* [http://en.wikipedia.org/wiki/Pseudoephedrine Pseudoephedrine] is a stimulant nasal decongestant[http://en.wikipedia.org/wiki/Decongestant] that is sometimes added to antihistamine preparations and other products, including some formulations sold under the [http://en.wikipedia.org/wiki/Sudafed Sudafed] brand. Pseudoephedrine has not been reported to have any adverse effect on helminths. | * [http://en.wikipedia.org/wiki/Pseudoephedrine Pseudoephedrine] is a stimulant nasal decongestant[http://en.wikipedia.org/wiki/Decongestant] that is sometimes added to antihistamine preparations and other products, including some formulations sold under the [http://en.wikipedia.org/wiki/Sudafed Sudafed] brand. Pseudoephedrine has not been reported to have any adverse effect on helminths. | ||
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* [https://en.wikipedia.org/wiki/Sodium_oxybate Sodium oxybate] (Xyrem, Alcover) is the sodium salt of [https://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid γ-hydroxybutyric acid] (GHB), which is unlikely to harm helminths because it’s an endogenous substance found naturally in the human body[https://www.facebook.com/groups/htsupport/permalink/813700862019204/?comment_id=815965665126057&offset=0&total_comments=23&comment_tracking=%7B%22tn%22:%22R%22%7D], and one hookworm/whipworm host has confirmed that it did not affect her worms.[https://www.facebook.com/groups/htsupport/permalink/813700862019204/?comment_id=815975511791739&offset=0&total_comments=24&comment_tracking=%7B%22tn%22:%22R%22%7D] | * [https://en.wikipedia.org/wiki/Sodium_oxybate Sodium oxybate] (Xyrem, Alcover) is the sodium salt of [https://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid γ-hydroxybutyric acid] (GHB), which is unlikely to harm helminths because it’s an endogenous substance found naturally in the human body[https://www.facebook.com/groups/htsupport/permalink/813700862019204/?comment_id=815965665126057&offset=0&total_comments=23&comment_tracking=%7B%22tn%22:%22R%22%7D], and one hookworm/whipworm host has confirmed that it did not affect her worms.[https://www.facebook.com/groups/htsupport/permalink/813700862019204/?comment_id=815975511791739&offset=0&total_comments=24&comment_tracking=%7B%22tn%22:%22R%22%7D] | ||
* [http://en.wikipedia.org/wiki/Steroid_hormone Steroid hormones]. One host of both hookworms and whipworms takes [http://en.wikipedia.org/wiki/Dehydroepiandrosterone DHEA], [http://en.wikipedia.org/wiki/Progesterone progesterone] and [http://en.wikipedia.org/wiki/Testosterone testosterone] with no adverse effect on her worms. | * [http://en.wikipedia.org/wiki/Steroid_hormone Steroid hormones]. One host of both hookworms and whipworms takes [http://en.wikipedia.org/wiki/Dehydroepiandrosterone DHEA], [http://en.wikipedia.org/wiki/Progesterone progesterone] and [http://en.wikipedia.org/wiki/Testosterone testosterone] with [https://www.facebook.com/groups/htsupport/permalink/824719590917331/?comment_id=825008124221811&offset=0&total_comments=1&comment_tracking=%7B%22tn%22:%22R%22%7D no adverse effect on her worms]. | ||
* ⚡ [http://en.wikipedia.org/wiki/Tetanus_vaccine Tetanus vaccine]. Three helminth hosts have claimed that they may have lost their hookworms after a tetanus shot, although others have had tetanus shots without any worm loss, and no problems have been reported with other vaccines. | * ⚡ [http://en.wikipedia.org/wiki/Tetanus_vaccine Tetanus vaccine]. Three helminth hosts have claimed that they may have lost their hookworms after a tetanus shot, although others have had tetanus shots without any worm loss, and no problems have been reported with other vaccines. | ||
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* ❌ [http://en.wikipedia.org/wiki/Turpentine Turpentine]. Also known as spirit of turpentine, oil of turpentine, wood turpentine and, colloquially, turps, this is distilled from pine tree resins. If applied topically to the skin - for example as a treatment for lice - it is unlikely to harm helminths. However, it has been used traditionally as an anthelminthic, so it may be harmful to human helminths if taken internally. It may, however, also be toxic to humans! | * ❌ [http://en.wikipedia.org/wiki/Turpentine Turpentine]. Also known as spirit of turpentine, oil of turpentine, wood turpentine and, colloquially, turps, this is distilled from pine tree resins. If applied topically to the skin - for example as a treatment for lice - it is unlikely to harm helminths. However, it has been used traditionally as an anthelminthic, so it may be harmful to human helminths if taken internally. It may, however, also be toxic to humans! | ||
* [http://www.netdoctor.co.uk/lung-problems/medicines/vicks-first-defence.html Vicks First Defence]. This cold preventative nasal spray does not contain antiviral chemicals, but forms a microgel that coats the lining of the nose to trap the cold virus and prevent this from reaching, and infecting, the cells within the nose. The microgel also reduces the pH inside the nose, which further helps by making it harder for the cold virus to multiply. It seems unlikely that any of this product’s ingredients would harm helminths, although there have been no reports to confirm this. | * [http://www.netdoctor.co.uk/lung-problems/medicines/vicks-first-defence.html Vicks First Defence]. This cold preventative nasal spray does not contain antiviral chemicals, but forms a microgel that coats the lining of the nose to trap the cold virus and prevent this from reaching, and infecting, the cells within the nose. The microgel also reduces the pH inside the nose, which further helps by making it harder for the cold virus to multiply. It seems unlikely that any of this product’s ingredients[http://www.vicks.co.uk/products/cold-intervention/vicks-first-defence-nasal-spray/] would harm helminths, although there have been no reports to confirm this. | ||
* <span id=VOCs></span>[http://en.wikipedia.org/wiki/Volatile_Organic_Compounds Volatile Organic Compounds] (VOCs), as found in paints, felt tip markers, etc., are unlikely to harm helminths. One helminth host who regularly worked with organic solvents (including CH2Cl2 and CHCl3) has reported that his helminths have not been affected. | * <span id=VOCs></span>[http://en.wikipedia.org/wiki/Volatile_Organic_Compounds Volatile Organic Compounds] (VOCs), as found in paints, felt tip markers, etc., are unlikely to harm helminths. One helminth host who regularly worked with organic solvents (including CH2Cl2 and CHCl3) has reported that his helminths have not been affected. | ||