Helminthic therapy and cardiometabolic conditions

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    Metabolic disorders are disorders that negatively alter the body's processing and distribution of proteins, fats and carbohydrates.
    Cardiovascular diseases involve the heart and blood vessels.

    Atherosclerosis[edit | edit source]

    See also (may not be related)

    Blood pressure[edit | edit source]

    Not everyone using helminthic therapy will experience a change in blood pressure.

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    We measure our blood pressure regularly at home. Did not have any change after inoculations. [1]
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    I have always tended to have blood pressure on the low end of normal, but have experienced no worsening of that condition or dizziness since hosting NA. [2]

    However, helminthic therapy can reduce blood pressure in some cases, especially if it had previously been elevated.

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    Both of my BP numbers dropped ten points VERY quickly after inoculation. [3]
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    … the worms dropped my high BP overall by about 15 points… [4]
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    I received my first dose of N.A. in early June. I just checked my blood pressure, and I had a lovely surprise. In six weeks, my systolic blood pressure has fallen by almost 30 points, and my diastolic blood pressure has dropped by 10 points. During my last visit, my doctor said that if my blood pressure increases I'll need medication, but I'm well out of range for that now! [5]
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    I can think of two or three instances where my BP was lower than normal as i was adjusting to the worms. This only lasted a few days. They (hookworms) drop my BP from 135/85 to 110/75, which was my norm before getting sick. My pulse also drops from resting 77 to around 60. [6] [7]

    The reduction in blood pressure seen by some users of helminthic therapy may be a result of the worms correcting an autoimmune condition.

    Lowered blood pressure may not be advantageous for everyone, especially those on the fatigue spectrum, in which case starting helminthic therapy with too high a dose might result in blood pressure dropping too far, causing dizziness or even a brief loss of consciousness.

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    Mine dropped when i had too high a dose of hookworm, got gastroenteritis, which triggered my dysautonomia and low BP and i kept passing out. [8]

    See also Helminthic therapy personal stories: Hypertension / high blood pressure

    Scientific studies

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    Helminth infections improve lipid profiles and may lower blood pressure.

    Several studies show a link between dysbiosis and hypertension. Helminths reshape microbiota and could therefore have an impact on these cases, which would be interesting to investigate.

    Reviews

    Cardiovascular disease[edit | edit source]

    Also see Atherosclerosis, above.

    Nearly half of all adult Americans have cardiovascular disease. [9]

    Immunotherapies that treat inflammatory conditions might have a role in the reduction of cardiovascular disease risks, [10] and anti-inflammatory medication allows patients with a history of heart attacks to enjoy a significantly lower incidence of recurrent cardiovascular events, [11] but these drugs may only be necessary because of the helminth deficiency that is widespread throughout the developed world in the twenty first century.

    This rigorous, comprehensive systematic review has revealed that individuals who are hosting helminths enjoy less dyslipidemia (unhealthy levels of fats in the blood), less metabolic syndrome, less diabetes, and less atherosclerotic cardiovascular disease.
    Its authors warn that, if individuals who are at moderate or high risk for cardiometabolic disease are deprived of their helminths as a result of de-worming campaigns, they may require an increase in preventive medical care to compensate for the loss of beneficial helminth-derived immune modulation.
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    … it is possible that the parasites in the bodies of the Tsimane help regulate their immune systems and protect their hearts.
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    Chronic infections, especially helminths, may offer protection against heart disease and diabetes through direct and indirect pathways.
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    … multiple lines of evidence support the notion that there is also an inverse relationship between helminthic infections and atherosclerosis and its related diseases. It is hereby hypothesized that worms are ‘protective’ against heart disease.

    See also

    Diabetes[edit | edit source]

    See Helminthic therapy and diabetes.

    Dyslipidemia[edit | edit source]

    Metabolic syndrome[edit | edit source]

    Helminth colonisation may provide protection against metabolic syndrome.

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    potential long-term effects of PSI (previous schistosome infection) may reduce the risk of metabolic syndrome.

    Non-alcoholic fatty liver disease (NAFLD)[edit | edit source]

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    … helminths and their products can treat or relieve non-alcoholic fatty liver disease (NAFLD)-related diseases, including obesity, diabetes, and metabolic syndrome, by promoting glycolipid metabolism homeostasis, regulating inflammation and restoring the balance of gut microbiota.

    See also

    Obesity[edit | edit source]

    See this article:

    Scientific publications

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    In this review we discuss how helminths, which are among the strongest natural inducers of type 2 immunity, and some of their unique immunomodulatory molecules, may contribute to the maintenance of tissue-specific and whole-body metabolic homeostasis and protection against obesity-associated meta-inflammation… Importantly, controlled human infection with Necator americanus shows promising results in terms of safety and tolerability…

    See also Helminthic therapy and diabetes

    See also (may not be related)

    Stroke[edit | edit source]

    See also (may not be directly related)

    General reviews[edit | edit source]

    The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

    the human hookworm, Necator americanus

    The introduction of an infectious agent into an organism. Helminth inoculation

    A helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.

    A helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    The specific population of microorganisms living in a certain part of the body, such as the gut. "Microbiome" refers to all the microorganisms living in and on the body, or the genome of these microorganisms. These two terms are often used interchangeably.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    An organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.)

    The species of human hookworm used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.

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