Helminthic therapy and eye health
The scientific evidence[edit | edit source]
see also
- 2025 Dec 29 The gut-eye axis in blinding eye diseases: microbiota-driven immune dysregulation and immunomodulatory therapies
- 2025 Mar 10 Short-Chain Fatty Acids and the Gut-Retina Connection: A Systematic Review
- 2025 Mar Microbiome-based therapeutics for ocular diseases
- 2023 Aug Gut microbiota and metabolites in diabetic retinopathy: Insights into pathogenesis for novel therapeutic strategies
- 2023 Jul 4 The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy
- 2022 Jul 8 Evidence Suggesting the Role of Gut Dysbiosis in Diabetic Retinopathy
- 2022 Jan 14 Gut Microbiome in Retina Health: The Crucial Role of the Gut-Retina Axis
- 2021 Dec 5 The role of inflammation and neurodegeneration in diabetic macular edema
- 2014 Sep Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol
[edit | edit source]
- 2026 Jul 11 Helminths Don't Just Quiet Inflammatory Th17 Cells — They Turn Them Into Tregs (Jacques Le Marois, Substack)
- 2021 Feb 2 Gross ways to live long: Parasitic worms as an anti-inflammaging therapy? -- Full text | PDF (Also reported by Press Release. [1])
See also
- 2025 Oct 1 Current and emerging therapies for dry and neovascular age-related macular degeneration -- Full text
- 2012 Nov 27 NIH study suggests immune system could play a central role in AMD
- 2009 Nov-Dec Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration
See also (VEGF)
- 2023 Jan 23 Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation -- Full text | PDF
- 2021 Nov 16 Diminished Circulating Levels of Angiogenic Factors and Rage Ligands in Helminth-Diabetes Comorbidity and Reversal Following Anthelmintic Treatment -- Full text | PDF
Diabetic retinopathy[edit | edit source]
See also
- 2026 Mar 11 Systematic review of ocular and circulatory cytokines linking diabetic retinopathy to kidney disease
- 2025 Dec Targeting the gut-retina axis: mechanistic insights and therapeutic prospects for diabetic retinopathy
- 2025 Jul 7 The role of gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy
- 2021 Feb 2 Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy
- 2019 Jul 1 Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy
- 2016 Dec 16 IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling
Glaucoma[edit | edit source]
See also
- 2024 Sep IL-17A enhances the inflammatory response of glaucoma through Act1/TRAF6/NF-κB pathway
- 2024 Jun 21 Role of T cell-induced autoimmune response in the pathogenesis of glaucoma
- 2023 Jun Interleukin-17A modulates retinal inflammation by regulating microglial activation via the p38 MAPK pathway in experimental glaucoma neuropathy
- 2021 Dec 16 T Cell-Mediated Autoimmunity in Glaucoma Neurodegeneration
- 2020 Jun Glaucoma is an autoimmune disease
- 2020 The role of commensal microflora-induced T cell responses in glaucoma neurodegeneration
- 2018 Aug 10 Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma (Science daily Glaucoma may be an autoimmune disease)
Reactive arthritis (Reiter's syndrome): eye disease manifestations[edit | edit source]
Eye symptoms often appear early, sometimes before joint complaints, with the most characteristic symptoms being:
- conjunctivitis (~50% of patients)
- uveitis/ iritis (~20-30%). Requires urgent treatment to prevent permanent vision damage.)
- episcleritis (less common).
See Helminthic therapy and arthritis: Reactive arthritis (Reiter's syndrome)
Sarcoidosis: eye disease manifestations[edit | edit source]
Sarcoidosis can affect virtually any structure of the eye, with ocular sarcoidosis occuring in approximately 25-50% of patients with systemic disease. If untreated, it can lead to serious complications including glaucoma, cataracts and blindness.
See Helminthic therapy and sarcoidosis
Sjogren's disease: eye disease manifestations[edit | edit source]
The hallmark ocular issue is dryness (keratoconjunctivitis sicca), with dry eye affecting ~80% of Sjögren's patients and often being one of the earliest symptoms. Without proper lubrication, long-term complications can threaten vision.
See Helminthic therapy and Sjögren's disease
Uveitis[edit | edit source]
Uveitis is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea.
See also
- Helminthic therapy and sarcoidosis
- 2026 Etiology of Uveitis: Infection or Autoimmunity? (Russian)
- 2020 Jun 17 Study of immunopathological mechanisms of autoimmune uveitis and the determination of new therapeutical options (Bachelor, Prague, Czech)
- 2019 Dec 11 Der Einfluss von Interleukin-10 auf den Phänotyp primärer Mikroglia (Thesis, Duisburg-Essen, German)