Helminthic therapy and arthritis
Arthritis is a general medical term used to describe a disorder that affects joints.
The scientific evidence[edit | edit source]
- 2024 Jun Helminth-induced impairment of humoral immunity differently contribute to their anti-arthritic effects in mice: Comparison of Schistosoma mansoni and Trichinella spiralis -- Full text
- 2024 Jan 31 The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner -- Full text | PDF
- 2022 Nov 12 Fasciola hepatica extract suppresses fibroblast-like synoviocytes in vitro and alleviates experimental arthritis -- Full text
- 2022 Feb 24 Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization -- Full text | PDF]
- 2021 Nov 8 Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts -- Full text | PDF
- 2021 Oct 18 Emerging Role of Eosinophils in Resolution of Arthritis -- Full text | PDF
- 2019 Oct 12 Th2 signals are not essential for the anti-arthritic effects of Trichinella spiralis in mice
- 2019 Apr 5 The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis -- Full text | PDF
- 2018 Sept 8 STAT6 & IL-10 are required for the anti-arthritic effects of Schistosoma mansoni via different mechanisms
- 2018 Aug 8 Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis -- Full text | PDF
- 2018 Jul 26 Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation -- Full text | PDF
- 2018 May 14 Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis -- Full text | PDF
- 2017 Jan 13 Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites
- 2016 Nov 1 Anti-Arthritic Activity of Schistosoma mansoni and Trichinella spiralis Derived-Antigens in Adjuvant Arthritis in Rats: Role of FOXP3+ Treg Cells -- Full text | PDF
- 2016 Oct Exploiting the helminth-derived immunomodulator, ES-62 and its small molecule analogues to dissect the mechanisms underpinning the development of the pathogenic phenotype of synovial fibroblasts in autoimmune arthritis -- PDF (thesis)
- 2016 Jun 9 Experimental arthritis: Helminth infection ameliorates arthritis (No abstract)
- 2016 Jun 7 Th2 and eosinophil responses suppress inflammatory arthritis -- Full text | PDF
- 2016 Apr Novel therapeutic compound tuftsin–phosphorylcholine attenuates collagen-induced arthritis -- Full text | PDF
- 2015 Jun Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome -- Full text | PDF
- 2014 Jun ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints -- Full text | PDF
- 2014 May Immunomodulation in human and experimental arthritis: including vitamin D, helminths and heat-shock proteins -- Full text
- 2012 Sept 27 The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites -- Full text | PDF
- 2012 Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells -- Full text | PDF
- 2011 Apr 18 Helminth parasites and the modulation of joint inflammation -- Full text | PDF
- 2011 Feb Infection with an intestinal helminth parasite reduces Freund's complete adjuvant-induced monoarthritis in mice -- Full text | PDF (HDC)
See also
The anecdotal evidence[edit | edit source]
For reports by individuals who have used helminthic therapy to treat arthritis, see: