Helminthic therapy and neuromuscular disorders

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Neuromuscular disorders are conditions affecting the peripheral nervous system (PNS), the neuromuscular junctions, or the skeletal muscles. Damage to any of these components of the motor unit can cause muscle atrophy and weakness, as well as issues with sensation. (List of neuromuscular disorders)

Myositis and dermatomyositis[edit | edit source]

“Six months ago, I took 10 hookworm. I've since had about 10 more. I have had great results. Skin softening, can almost make a fist now and can drink from a water bottle without spilling water all down my front because my lips have softened and can seal around the nozzle. My muscles are not burning when I exercise and I can build fitness where before if I did more than a gentle walk I would have to rest for a couple of days. I just don't have to pace myself like I did, no myositis flares in 6 months and have weaned from 7.5 mg prednisone down to 4.5. My energy is hugely improved (better than I remember even before I got scleroderma). My raynauds has mostly gone (its summer here but last summer it still appeared). I feel like I have my life back!” [1]

And from the same individual, 6 years later.

(At 6 years) "Myositis is completely in remission. Scleroderma 90% better. I'm off all steroids and immunosuppressive drugs for years now. I started with NA and now do 2 species which is even better. I added tso a couple of years ago... Small improvements at first. It took 1-2 years for remission." [2]

“I am 7 months in to treatment for dermatomyositis and other autoimmune problems. I have 35 hookworms and have recovered almost completely. I had sun sensitivity, food allergies and skin problems which are all gone.” [3]

“I have Mixed Connective Tissue Disease - Lupus with a likely DM (dermatomyositis) overlap… I'm 14 months into HT and about 85 to 90% improved!” [4]

The following resounding success was reported in a private message from an individual with MCTD - a crossover syndrome that includes components of scleroderma, dermatomyositis and polymyositis, as well as lupus - who had been on hydroxychloroquine and prednisone for 5 years.

The worms have been working for me. I have been in drug free remission for over 3 months now, I hypothesize that other lupus-spectrum disorders will respond similarly. After all, HLA-B27 is an autoimmune marker that is shared by inflammatory bowel disease as well as lupus/MCTD.

A more detailed story:

My scleroderma helminth journey

Guillain–Barré Syndrome[edit | edit source]

2012 May 10 IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity -- Full text (Coverage : Injection offers hope for treating auto-immune disease

Until quite recently, medical treatments for Guillain–Barré syndrome and other autoimmune diseases have tended to concentrate on attacking the “bad” effector cells, but a treatment reported in early 2012, and shown to be successful against Guillain–Barré syndrome in rats, increased the "good" regulatory cells. Not only did the sick rats recover much more quickly as a result of this treatment, but those treated prophylactically did not fall ill. [21] The authors of this study point to the fact that their treatment has a similar effect to that observed in patients infected with helminths, both of which approaches regulate the immune system and boost T-cell production in a similar manner.

Myasthenia gravis[edit | edit source]

Hi, yes the (NA hookworms) definitely help with myasthenia gravis. I have MG and I know this treatment works for me… The benefit was gradual, but I was doing hour long spinning classes 5 mths into the treatment. I had strength and endurance which I had completely lost to the MG… I accidentally killed (my worms) with oregano extract in December. My symptoms rebounded quite fast and that was totally scary. I couldn't work out anymore due to muscle fatigue etc. I have noticed that although it has only been 3 wks or so (since I re-dosed), my legs don't shake when I go up stairs, my double vision is gone, and I am starting to feel strong again. (Reported in a private discussion, Apr 2012)

Hi, I just wanted to let people out there know that I have been using HDC with great success for the last 6 months. I have lupus and myasthenia gravis and it has definitely helped. Along with hdc I do also use NA and have been for three years, though for me it wasn't enough on its own and it gave me severe gi issues. I lost my hookworms frequently, but after adding the HDC I have not had that happen. One huge bonus for me is that I have had hair grow in that I thought was permanently gone due to the lupus. (Reported in Mar 2014.)

Stiff-person syndrome (SPS)[edit | edit source]

Stiff-person syndrome (SPS), also known as stiff-man syndrome, is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms, resulting in postural deformities. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms.

There are no studies or testimonials on the effect of helminths on this syndrome. However, there are studies and case reports on autoimmune diseases often associated with this syndrome, such as type 1 diabetes. Animal models are easily treated with corticosteroids. Rituximab is one of the treatments also used for other autoimmune diseases for which helminths appear to be effective. In other words, helminths are a potential avenue worth exploring.