Helminthic therapy and psoriasis

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Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin.

The scientific evidence

• 2025 Mar 27 Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis -- Full text | PDF

• 2023 Dec 27 Trichinella pseudospiralis-secreted 53 kDa protein ameliorates imiquimod-induced psoriasis by inhibiting the IL-23/IL-17 axis in mice -- Full text | PDF

• 2023 Aug 12 A target-based discovery from a parasitic helminth as a novel therapeutic approach for autoimmune diseases -- Full text

• 2016 Oct 15 Mucosal and systemic immune modulation by Trichuris trichiura in a self-infected individual -- PDF (TTO)

• 2006 Jun Prevention of psoriasis-like lesions development in fsn/fsn mice by helminth glycans

See also Helminthic therapy research

The anecdotal evidence

The first two reports and video are more detailed than the quotes that follow them.

• The effects of NA on psoriasis

• Hook me up! Treating autoimmune disease with hookworms (re. guttate psoriasis)

• An adaptive trial for psoriasis using hookworm

• “The psoriasis i used to get has also completely gone.” (Link expired)

• The following two reports are from the same person, four months apart.
  • "I have 25 hookworms so far and my psoriasis is almost gone.. I have had it all over my head for my whole life and have had it on my face before as well as my arms... I got the worms because I have M.S. and I have had no more symptoms so far. I got them around 5 months ago…" (Link expired)
  • “Well my psoriasis is 90 present gone but sometimes I get a little then it goes away again . These are very good results seeing as I have had it my whole life.” (Link expired)

• “Over the last 20 years I have tried everything the NHS has offered me - methotrexate, cyclosporin, fumaric acid esters, UV treatments, dithranol - among other things - but I've *never* seen results anything like this. The only treatment I have had in the last year is hookworms. At about 9 months in, most of my torso cleared up in the space of a couple of weeks. Then about a month ago my legs cleared up almost overnight. So I seem to have had little spurts of healing, rather than a constant improvement. I have continued to use dovobet ointment most days throughout the hookworm treatment, just because I find it prevents my plaques from building up and becoming cracked and painful. But I've been doing that for about fifteen years anyway, so I'm confident that the worms are the reason for this big change! I don't have psoriatic arthritis, but I did have a lot of muscle pain in my joints due to hypermobility, and that has improved a great deal as well. To get these results without side-effects, without daily trips to hospital or monthly blood-tests and blood-pressure monitoring, without risking melanoma or chemical burns, without killing my immune system and suffering repeated infections... it just seems too good to be true. I really couldn't be happier with the results!” (Edited from several posts.) Read more, and see the before and after pictures - [1] [2] [3]

• ☹️ “I've tried helminths treatment for my psoriasis (105 NA worms in doses of 35) almost 2 years in with absolutely no results... very discouraging... I still suffer like a bastard with psoriasis. In fact it has only progressed.” [4]

• “I've had huge success with my psoriasis taking only a single inoculation of 25 NA larvae. From a PSA score of at my worst nearly 9 to now only just on the scale.” [5]

• “At about 7 months (with NA)... all I had left was a gluten allergy and the psoriasis that was remaining in hair (body had cleared)... At a year and a half my psoriasis is gone...” [6]

• ☹️ “I started the worms (HDC) to help with my psoriasis and thyroid, (but) they never changed anything concerning those two things.” [7]

• "Prior to treating myself with NA, I suffered from very bad seborrhoeic dermatitis or psoriasis on my scalp and sometimes on other parts of my body for more than 10 years. I didn't have a proper diagnosis so I couldn't confirm exactly which one it was. I started noticing some good improvements after having my third NA dose. It's been 3 years now and my skin is still completely clear. All I have to do is inoculate myself with 10 NAs once every few months." [8]

• "My Brother does NA and TTO and that helps with psor /PSA. One species was an intermittent relief for him and the second stabilized the benefit to be persistent." [9]

See also

• The effects of helmithic therapy on psoriatic arthritis

The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

the ova (eggs) of the human whipworm, Trichuris trichiura

A helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.

A helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.

An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

the human hookworm, Necator americanus

The introduction of an infectious agent into an organism. Helminth inoculation

The active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state.

Hymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta