Helminthic therapy and respiratory disease

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Scientific papers[edit | edit source]

1995 Nov 15 Neutrophil inhibitory factor prevents neutrophil-dependent lung injury

Acute respiratory distress syndrome (ARDS)[edit | edit source]

Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Symptoms include shortness of breath (dyspnea), rapid breathing (tachypnea), and bluish skin coloration (cyanosis). For those who survive, a decreased quality of life is common.

Causes may include sepsis, pancreatitis, trauma, pneumonia, and aspiration.

Acute lung injury (ALI)[edit | edit source]

Acute lung injury is a disorder of acute inflammation that causes disruption of the lung endothelial and epithelial barriers.

Aspirin-exacerbated respiratory disease (AERD)[edit | edit source]

Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's triad or Widal's triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).

The following two reports are by the same person, two years apart.
- "My father… has something called Samter's syndrome which includes nasal polyps, chronic rhinitis, and aspirin sensitivity. For 20-25 years, he had little senses of taste or smell, from polyps on his sinus nerve, and had multiple surgeries to remove them. Starting about 6 months after getting HW (by then, he had about 50, I think), the polyps went away, never to return. He's had his taste and smell all the time, acutely, for now a good 3½ years." (Reported in a private discussion, Mar 2012)
- “Now he is getting the same efficacy from HDC.” [1]

"Wow this is amazing! I was diagnosed with Samters Triad / Aspirin Exaccerbated Respiratory Disease (AERD) in Oct 2014. Samters Triad is salicylate intolerance, nasal polyps and asthma… I decided to give HW a go in Jul 2015. My initial dose was 25. After 3 months I noticed I could get away with the odd glass of wine without an anti-histamine. In Oct I took a further 40 HW. Then suddenly about 10 days ago (mid January 2016) my nose cleared, and my energy levels escalated. I started cutting back my asthma medication and have taken nothing at all for 4 days now with no symptoms!” [2]

“I have AERD (Samter's Triad). Asthma, nasal polyps, and aspirin sensitivity. I've taken incredible amounts of prednisone to control the polyps and have had two surgeries to remove them over the last ten years… Started worms a few years ago. Initially HDC, which worked well and would provide relief for weeks. Made the move to NA and have had similar success there, it just lasts longer. I see improvement with as little as 30 NA, but get better control with 60-70. I currently take: Singular 10mg, Advair (250/50) as needed, and Pulmicort off label usage. With worms, I'm able to not take prednisone or aspirin… The worms make a night and day difference. Without them I would be in a bad place.” [3]

Asthma[edit | edit source]

See Helminthic therapy and asthma

Bronchiolitis[edit | edit source]

See Helminthic therapy and infectious diseases: Helminths and respiratory syncytial virus (RSV)

Chronic obstructive pulmonary disease (COPD)[edit | edit source]

See Helminthic therapy and chronic obstructive pulmonary disease (COPD).

Cystic fibrosis[edit | edit source]

See Helminthic therapy and cystic fibrosis

COVID-19[edit | edit source]

See Helminthic therapy and COVID-19

Idiopathic pulmonary fibrosis[edit | edit source]

2018 Sep Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis

maybe not relevant :

2026 Sep 30 Type 2 immune history trains lung macrophages for viral disease tolerance (Nature) (Online ahead of print)
2026 Jun 7 Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression
2025 Sep 8 Selective packaging of anti-fibrotic and tumour suppressor miRNAs in extracellular vesicles of a parasitic whipworm (Conference)
2024 Sep 11 IL-10 deficiency aggravates cell senescence and accelerates BLM-induced pulmonary fibrosis in aged mice via PTEN/AKT/ERK pathway
2022 Jul 30 Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa

Influenza[edit | edit source]

See Helminthic therapy and infectious diseases: Helminths and influenza

Interstitial lung disease (ILD)[edit | edit source]

I am using NA for interstitial lung disease that seems to have developed from RA. I inoculated in August 2016 with only 5 NA and within 10 weeks symptoms were better. [4]

Lung transplantation[edit | edit source]

See Helminthic therapy and organ transplantation

Lung ischemia-reperfusion injury (IRI)[edit | edit source]

See Helminthic therapy and cardiometabolic conditions: Ischemia-reperfusion injury (IRI)

Nasal polyposis[edit | edit source]

See Helminthic therapy and rhinosinusitis

Pleurisy[edit | edit source]

Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the chest cavity (pleurae).

2018 Feb 9 Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation

Using the carrageenan-induced pleural inflammation model, we demonstrated the ability of SmKI-1 to inhibit early events that trigger neutrophil recruitment in the pleural cavities of mice in response to inflammatory stimuli.

Pneumocystosis[edit | edit source]

2021 Dec 31 Prevalence of Pneumocystosis in Sub-Saharan Africa and Helminth Immune Modulation

Pneumonia[edit | edit source]

Pneumonia] is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli. Pneumonia is usually caused by infection with viruses or bacteria, and less commonly by other microorganisms.

See Helminthic therapy and infectious diseases: Helminths and Streptococcus pneumoniae